{"id":129181,"date":"2026-09-09T15:09:55","date_gmt":"2026-09-09T15:09:55","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/?page_id=129181"},"modified":"2026-09-10T07:57:53","modified_gmt":"2026-09-10T07:57:53","slug":"adaptchem","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/projects\/adaptchem\/","title":{"rendered":"ADAPTCHEM"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"vf-lede\">Adaptive capacity of marine microbial communities to anthropogenic chemicals<\/p>\n<!--\/vf-lede-->\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Anthropogenic chemical pollution is an accelerating planetary-scale stressor that profoundly impacts marine ecosystems. Microbial communities mediate the fate of most environmental contaminants and are responsible for the planet\u2019s primary chemical-buffering capacity. Yet we lack a mechanistic understanding of how exposure, biodiversity, and evolutionary history shape microbial resilience to increasingly complex pollutant mixtures. This project integrates natural marine ecotron communities and large-scale chemical\u2013microbial interaction profiling to elucidate how marine microbes adapt to &#8211; and potentially mitigate &#8211; the impact of pesticide and pollutant mixtures. The results will deepen our insights into mechanistic planetary-scale biology by linking genetic and biochemical processes with community dynamics and ecosystem-level resilience.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div style=\"height:34px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"457\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-1_revised-1024x457.png\" alt=\"\" class=\"wp-image-129187\" srcset=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-1_revised-1024x457.png 1024w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-1_revised-300x134.png 300w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-1_revised-768x343.png 768w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-1_revised-1536x685.png 1536w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-1_revised.png 1712w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">Figure 1. Experimental workflow showing adaptation of marine communities to pesticides, followed by cell abundance analysis, sequencing and LC\/MS-based pollutant degradation analysis. <em>Image generated by ChatGPT.<\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Objectives<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Quantify adaptive trajectories and fitness tradeoffs in natural marine microbial communities exposed to anthropogenic chemical mixtures.<\/li>\n\n\n\n<li>Identify species-level mechanisms underlying resilience or vulnerability to pollutant exposure and discover new metabolic pathways.&nbsp;<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">We integrate ecotron experiments and chemostat-based continuous culture adaptation with high-throughput LC-MS metabolomics, 16S rRNA amplicon sequencing and flow cytometry to elucidate community-level resilience, functional reorganization, and adaptive dynamics under ecologically realistic conditions, as depictured in Figure 1.<\/p>\n\n\n\n<div style=\"height:34px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"873\" height=\"1024\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-2-1-873x1024.jpeg\" alt=\"\" class=\"wp-image-129365\" style=\"aspect-ratio:0.8408169628936701;width:518px;height:auto\" srcset=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-2-1-873x1024.jpeg 873w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-2-1-256x300.jpeg 256w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-2-1-768x901.jpeg 768w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-2-1-1309x1536.jpeg 1309w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Adaptchem_Fig-2-1-1746x2048.jpeg 1746w\" sizes=\"auto, (max-width: 873px) 100vw, 873px\" \/><figcaption class=\"vf-figure__caption\"><strong>Fig<\/strong>ure 2. An in-house-built chemostat system with six parallel cultures to enable long-term microbial adaptation under continuous pesticide exposure. <em>Credit: Dragana Despotovic. <\/em><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Project lead<\/h3>\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"b0977649\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=Michael%20Zimmermann&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Cphones%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-inline -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"88612\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60031476.jpg?itok=XXhmnt8h\" alt=\"image of Michael Zimmermann\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.embl.org\/people\/person\/michael-zimmermann\" class=\"vf-profile__link\">Michael Zimmermann<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Group Leader\n        <\/p>\n      \n      \n      \n      \n      \n      \n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/88612\/88612\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Lead scientist<\/h3>\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"3a37acd7\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=Dragana%20Despotovic&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Cphones%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-inline -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"190375\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60044935.jpg?itok=s9VGoKdj\" alt=\"image of Dragana Despotovic\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.embl.org\/people\/person\/dragana-despotovic\" class=\"vf-profile__link\">Dragana Despotovic<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Postdoctoral Fellow (EIPOD)\n        <\/p>\n      \n      \n      \n      \n      \n      \n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/190375\/190375\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n\n\n<div style=\"height:29px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Collaborator<\/h3>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"300\" height=\"296\" src=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Maria-da-villa_Adaptchem-profile_cropped-300x296.png\" class=\"vf-profile__image\" alt=\"\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Maria-da-villa_Adaptchem-profile_cropped-300x296.png 300w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2026\/09\/Maria-da-villa_Adaptchem-profile_cropped.png 553w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\n    <h3 class=\"vf-profile__title\" >\n                    <a href=\"https:\/\/www.idaea.csic.es\/person\/maria-vila-costa\/\" target=\"_self\" class=\"vf-profile__link\">Maria Vila-Costa<\/a>\n            <\/h3>\n    \n                <p class=\"vf-profile__text\" >\n                IDAEA Barcelona            <\/p>\n    \n    \n      \n\n    \n<\/article>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":5,"featured_media":0,"parent":714,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-129181","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/129181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/comments?post=129181"}],"version-history":[{"count":10,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/129181\/revisions"}],"predecessor-version":[{"id":129369,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/129181\/revisions\/129369"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/714"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/media?parent=129181"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=129181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}