{"id":1151,"date":"2024-04-26T11:09:37","date_gmt":"2024-04-26T11:09:37","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/?page_id=1151"},"modified":"2024-05-15T14:28:32","modified_gmt":"2024-05-15T14:28:32","slug":"grasshopper","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/projects\/grasshopper\/","title":{"rendered":"Grasshopper"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"vf-lede\">Evolution and transcriptional dynamics of toxin resistance in the grasshopper mouse.<\/p>\n<!--\/vf-lede-->\n\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2024\/04\/grasshopper-visual-1024x576.jpg\" alt=\"otorridus vs beetle\" class=\"wp-image-1188\" srcset=\"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2024\/04\/grasshopper-visual-1024x576.jpg 1024w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2024\/04\/grasshopper-visual-300x169.jpg 300w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2024\/04\/grasshopper-visual-768x432.jpg 768w, https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-content\/uploads\/2024\/04\/grasshopper-visual.jpg 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">Photo by Ann Prum, Coneflower Studios https:\/\/coneflowerstudios.com<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>Predatory grasshopper mice (<em>Onychomys torridus)<\/em> have co-evolved resistance to painful and lethal neurotoxins produced by the bark scorpion and pinacate beetle. We are employing a comparative genomics framework to understand the genetic adaptations for toxin resistance in grasshopper mice.<\/p>\n\n\n\n<p>We have created reference genomes for the three <em>Onychomys<\/em> species and deer mouse (<em>Peromyscus eremicus), <\/em>the closest outgroup. We are currently identifying loci that have undergone species-specific changes of evolutionary constraint in coding genes, non-coding genes, and regulatory elements contributing to toxin resistance. In this project, we will carry out functional data experiments to determine genes which are involved in the response to toxin exposure in <em>Onychomys<\/em>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Collaborators<\/h3>\n\n\n\n<p>Rowe lab, University of Oklahoma<\/p>\n\n\n\n<p class=\"vf-u-margin__bottom--800\"><\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Project lead<\/h3>\n\n\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":714,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-1151","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/1151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/comments?post=1151"}],"version-history":[{"count":12,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/1151\/revisions"}],"predecessor-version":[{"id":2194,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/1151\/revisions\/2194"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/pages\/714"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/media?parent=1151"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/planetary-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=1151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}