{"id":93,"date":"2020-10-28T12:42:39","date_gmt":"2020-10-28T12:42:39","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/mmpu\/?page_id=93"},"modified":"2026-01-23T10:28:18","modified_gmt":"2026-01-23T10:28:18","slug":"translational-rna-biology","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/mmpu\/research-groups\/translational-rna-biology\/","title":{"rendered":"Translational RNA biology"},"content":{"rendered":"\n
\n
\n\n

Group leaders: Matthias W. Hentze and Andreas E. Kulozik<\/h2>\n\n\n\n

Our research interest<\/h3>\n\n\n\n

Our team focuses on basic and translational aspects of RNA biology in cancer, with a particular focus on childhood cancers. Specific areas of interest include cell stress-induced changes in posttranscriptional gene regulation, altered behaviour of RNA-binding proteins (RBPs) in cancer, synthetic lethality relationships in cancer, the roles of RBPs in modulating the efficacy of existing chemotherapeutics, and drug repurposing efforts to bring our discoveries towards translational applications.
Our team using a diverse array of approaches, from classical molecular and cellular biochemistry techniques to state-of-the-art proteomic screening methods. Through further collaborations with the groups of Dr. Chris Carnie<\/a> and Prof. Thomas Gr\u00fcnewald<\/a>, we supplement our expertise with complementary genetic screening approaches and in vivo models of pediatric sarcomas.<\/p>\n\n\n\n

Background<\/h3>\n\n\n\n

Initially, our group\u2019s interest in RNA biology arose from detailed clinical analyses of two common hematological disorders, \u00df-thalassemia and thrombophilia, respectively. Interestingly, it is now becoming apparent that the principles that have been uncovered by the analysis of these two model conditions are applicable more generally.<\/p>\n\n\n\n

Furthermore, the results of these projects have illustrated that the detailed analysis of unexplained medical phenomena can result in the identification and characterization of previously unrecognized basic biological mechanisms with broad implications.<\/p>\n\n\n\n

Indeed, our recent work has highlighted a wealth of RBPs that exhibit differential RNA-binding in osteosarcoma, a childhood bone cancer with an urgent need for better treatment options.<\/p>\n\n\n\n

Goals<\/h3>\n\n\n\n

Our driving aim is to build upon mechanistic discoveries that have the potential to both transform our understanding of fundamental biology and highlight promising new therapeutic strategies for childhood cancers including but not limited to osteosarcoma. Our unique partnership enables deep mechanistic characterisation of \u2018disease-relevant\u2019 RNA biology as well as a clear translational line-of-site towards identifying the next generation of therapeutic interventions.<\/p>\n\n\n\n

Join us!<\/h3>\n\n\n\n

We are always keen to hear from others who share our interest in these fundamental areas of biology, and welcome speculative applications from prospective research assistants, master\/doctoral students and postdocs.<\/p>\n\n\n\n

<\/p>\n\n\n\n

\n\nSelected publications<\/summary>\n
\n\n

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.<\/a>
Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE.
Nat Commun. 2024 Apr 1;15(1):2810. doi: 10.1038\/s41467-024-47031-y.PMID: 38561347<\/p>\n\n\n\n

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.<\/a>
Powers KT, Stevenson-Jones F, Yadav SKN, Amthor B, Bufton JC, Borucu U, Shen D, Becker JP, Lavysh D, Hentze MW, Kulozik AE, Neu-Yilik G, Schaffitzel C.
Nucleic Acids Res. 2021 Jul 21;49(13):7665-7679. doi: 10.1093\/nar\/gkab532. PMID: 34157102<\/p>\n\n\n\n

NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes.
<\/a>Becker JP, Helm D, Rettel M, Stein F, Hernandez-Sanchez A, Urban K, Gebert J, Kloor M, Neu-Yilik G, von Knebel Doeberitz M, Hentze MW, Kulozik AE.
iScience. 2021 Apr 1;24(4):102389. doi: 10.1016\/j.isci.2021.102389. eCollection 2021 Apr 23. PMID: 33981976<\/p>\n\n\n\n

Pharmacological inhibition of nonsense-mediated RNA decay augments HLA class I-mediated presentation of neoepitopes in MSI CRC<\/a>
Jonas P. Becker, Dominic Helm, Mandy Rettel, Frank Stein, Alejandro Hernandez-Sanchez, Katharina Urban, Johannes Gebert, Matthias Kloor, Gabriele Neu-Yilik, Magnus von Knebel Doeberitz, Matthias W. Hentze, Andreas E. Kulozik
bioRxiv:2020 Oct 13 doi: https:\/\/doi.org\/10.1101\/2020.10.13.319970<\/p>\n\n\n\n

Prexasertib (LY2606368) reduces clonogenic survival by inducing apoptosis in primary patient-derived osteosarcoma cells and synergizes with cisplatin and talazoparib.<\/a>
Heidler CL, Roth EK, Thiemann M, Blattmann C, Perez RL, Huber PE, Kovac M, Amthor B, Neu-Yilik G, Kulozik AE.
Int J Cancer. 2020 Aug 15;147(4):1059-1070. doi: 10.1002\/ijc.32814. Epub 2019 Dec 19. PMID: 31782150<\/p>\n\n\n\n

(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A.<\/a>
Michalak M, Katzenmaier EM, Roeckel N, Woerner SM, Fuchs V, Warnken U, Yuan YP, Bork P, Neu-Yilik G, Kulozik A, von Knebel Doeberitz M, Kloor M, Kopitz J, Gebert
J. Int J Mol Sci. 2020 Jul 23;21(15):5234. doi: 10.3390\/ijms21155234. PMID: 32718059<\/p>\n\n\n\n

UPF1-Mediated RNA Decay-Danse Macabre in a Cloud.<\/a>
Lavysh D, Neu-Yilik G.
Biomolecules. 2020 Jul 4;10(7):999. doi: 10.3390\/biom10070999. PMID: 32635561<\/p>\n\n\n\n

Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins<\/a>
Michael Backlund, Frank Stein, Mandy Rettel, Thomas Schwarzl, Joel I Perez-Perri, Annika Brosig, Yang Zhou, Gabriele Neu-Yilik, Matthias W Hentze, Andreas E Kulozik
Nucleic Acids Research, 20 April 2020, gkaa256, https:\/\/doi.org\/10.1093\/nar\/gkaa256<\/p>\n\n\n\n

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations. <\/a>
Trzaska C, Amand S, Bailly C, Leroy C, Marchand V, Duvernois-Berthet E, Saliou JM, Benhabiles H, Werkmeister E, Chassat T, Guilbert R, Hannebique D, Mouray A, Copin MC, Moreau PA, Adriaenssens E, Kulozik A, Westhof E, Tulasne D, Motorin Y, Rebuffat S, Lejeune F.
Nat Commun. 2020 Mar 20;11(1):1509. doi: 10.1038\/s41467-020-15140-z. PMID: 32198346<\/p>\n\n\n\n

Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.<\/a>
Perez-Perri JI, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, Brosig A, Hentze MW.
Nat Commun. 2018 Oct 23;9(1):4408. doi: 10.1038\/s41467-018-06557-8. PMID:30352994<\/p>\n\n\n\n

Dual function of UPF3B in early and late translation termination<\/a>
Gabriele Neu-Yilik, Etienne Raimondeau, Boris Eliseev, Lahari Yeramala, Beate Amthor, Aur\u00e9lien Deniaud, Karine Huard, Kathrin Kerschgens, Matthias W. Hentze, Christiane Schaffitzel, Andreas E. Kulozik
EMBO J. 2017 Oct 16;36(20):2968-2986. doi: 10.15252\/embj.201797079. Epub 2017 Sep 12. PMID:28899899<\/p>\n\n\n\n

NOTCH1<\/em> mutation, TP53<\/em> alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia.<\/a>
Hof J, Kox C, Groeneveld-Krentz S, Bandapalli OR, Karawajew L, Schedel K, Kunz JB, Eckert C, Ludwig WD, Ratei R, Rhein P, Henze G, Muckenthaler MU, Kulozik AE, von Stackelberg A, Kirschner-Schwabe R.
Haematologica. 2017 Jul;102(7):e249-e252. doi: 10.3324\/haematol.2016.157792. Epub 2017 Mar 30. PMID: 28360149<\/p>\n\n\n\n

Insights into the design and interpretation of iCLIP experiments.<\/a>
Haberman N, Huppertz I, Attig J, K\u00f6nig J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J.
Genome Biol. 2017 Jan 16;18(1):7. doi: 10.1186\/s13059-016-1130-x. PMID: 28093074<\/p>\n\n\n\n

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.<\/a>
Hauer C, Sieber J, Schwarzl T, Hollerer I, Curk T, Alleaume AM, Hentze MW, Kulozik AE.
Cell Rep. 2016 Aug 9;16(6):1588-603. doi: 10.1016\/j.celrep.2016.06.096. Epub 2016 Jul 28.
PMID: 27475226<\/p>\n\n\n\n

The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion.<\/a>
Hollerer I, Curk T, Haase B, Benes V, Hauer C, Neu-Yilik G, Bhuvanagiri M, Hentze MW, Kulozik AE.
RNA. 2016 Jul 12. [Epub ahead of print]
PMID: 27407180<\/p>\n\n\n\n

Proteomic analysis reveals branch-specific regulation of the unfolded protein response by nonsense-mediated mRNA decay<\/a>
Sieber, J., Hauer, C., Bhuvanagiri, M., Leicht, S., Krijgsveld, J., Neu-Yilik, G., Hentze, M.W., Kulozik, A.E.
Molecular & Cellular Proteomics 2016 Feb 20 pii: mcp.M115.054056.<\/p>\n\n\n\n

Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.<\/a>
Hauer C, Curk T, Anders S, Schwarzl T, Alleaume AM, Sieber J, Hollerer I, Bhuvanagiri M, Huber W, Hentze MW, Kulozik AE.
Nat Commun. 2015 Aug 11;6:7921. doi: 10.1038\/ncomms8921. PMID: 26260686<\/p>\n\n\n\n

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.<\/a>
Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C.
Nucleic Acids Res. 2015 Jun 30. pii: gkv668.<\/p>\n\n\n\n

The best of 25 years: mRNA 3’end processing.<\/a>
Hollerer I, Kulozik AE.
RNA. 2015 Apr;21(4):640-1. doi: 10.1261\/rna.050062.115<\/p>\n\n\n\n

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion<\/a>.
Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE.
EMBO Mol Med. 2014 Oct 15. pii: e201404461. doi: 10.15252\/emmm.201404461.<\/p>\n\n\n\n

mRNA 3’end processing: A tale of the tail reaches the clinic<\/a>
Ina Hollerer, Kerstin Grund, Matthias W. Hentze, Andreas E. Kulozik
EMBO Mol Med. 2014 Jan 1;6(1):16-26. doi: 10.1002\/emmm.201303300.<\/em><\/p>\n\n\n\n

Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond.<\/a>
Danckwardt S, Hentze MW, Kulozik AE.
J Mol Med (Berl). 2013 Aug 17.<\/em><\/p>\n\n\n\n

Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay<\/a>.
Singh KK, Wachsmuth L, Kulozik AE, Gehring NH._
RNA Biol. 2013 Aug 1;10(8):1291-1298. Epub 2013 Jul 23_<\/em><\/p>\n\n\n\n

Notch1 activation clinically antagonizes the unfavorable effect of pten inactivation in bfm-treated children with precursor t-cell acute lymphoblastic leukemia<\/a>.
Bandapalli OR, Zimmermann M, Kox C, Stanulla M, Schrappe M, Ludwig WD, Koehler R, Muckenthaler MU, Kulozik AE
Haematologica 2013 Jun;98:928-936<\/em><\/p>\n\n\n\n

Krebs, Blutgerinnung und Stress \u2013eine ungew\u00f6hnliche M\u00e9nage-\u00e0-trois<\/a>
Matthias W. Hentze und Andreas E. Kulozik
Spektrum der Wissenschaft, Juli 2012<\/p>\n\n\n\n

Stay tuned: miRNA expression and nonsense-mediated decay in brain development.<\/a>
Kulozik AE.
Mol Cell. 2011 May 20;42(4):407-8
Download pdf<\/a><\/p>\n\n\n\n

Mechanism of escape from nonsense-mediated mRNA decay of human {beta}-globin transcripts with nonsense mutations in the first exon.<\/a>
Neu-Yilik G, Amthor B, Gehring NH, Bahri S, Paidassi H, Hentze MW, Kulozik AE.
RNA.<\/em> 2011 May;17(5):843-54. Epub 2011 Mar 9<\/p>\n\n\n\n

p38 MAPK controls prothrombin expression by regulated RNA 3′ end processing.<\/a>
Danckwardt S, Gantzert AS, Macher-Goeppinger S, Probst HC, Gentzel M, Wilm M, Gr\u00f6ne HJ, Schirmacher P, Hentze MW, Kulozik AE.
Mol Cell.<\/em> 2011 Feb 4;41(3):298-310<\/p>\n\n\n\n

ALL can be separated from NOTCH pathway activation by FBXW7 loss of function.<\/a>
Kox, C, M. Zimmermann, M. Stanulla, M. S. Leible, M. Schrappe, W.-D. Ludwig, M. Muckenthaler, A.E. Kulozik.
Leukemia.<\/em> 2010 Dec;24(12):2005-13. Epub 2010 Oct 14<\/p>\n\n\n\n

Taking childhood leukemia personally.<\/a>
Kulozik AE.
Blood.<\/em> 2010 Dec 2;116(23):4737-8<\/p>\n\n\n\n

NMD: RNA biology meets human genetic medicine<\/a>.
Bhuvanagiri, M, A. M. Schlitter, M. W. Hentze, A. E. Kulozik.Biochemical Journal<\/em> (2010) Aug 27;430(3):365-77<\/p>\n\n\n\n

Disassembly of exon junction complexes by PYM<\/a>.
Gehring N.H., S. Lamprinaki, A.E. Kulozik, M.W. Hentze.
Cell.<\/em> 2009 May 1;137(3):536-48<\/p>\n\n\n\n

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay<\/a>
Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE.PLoS Biol.<\/em> 2009 May 26;7(5):e1000120. Epub 2009 May 26<\/p>\n\n\n\n

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathway<\/a>s.
Ivanov P., N. Gehring, J. Kunz, M.W. Hentze, A.E. Kulozik.
EMBO J.<\/em> 2008 Mar 5;27(5):736-47. Epub 2008 Feb 7.<\/p>\n\n\n\n

3′ end mRNA processing: Molecular mechanisms and implications for health and disease<\/a>.
Danckwardt, S., M.W. Hentze, A.E. Kulozik.
EMBO J.<\/em> 2008 Feb 6;27(3):482-98.<\/p>\n\n\n\n

Splicing factors stimulate polyadenylation via USEs at non-canonical 3\u2019 end formation signals<\/a>.
Danckwardt, S., I. Kaufmann, M. Gentzel, K. F\u00f6rstner, A.S. Gantzert, N.H. Gehring, G. Neu-Yilik, P. Bork, W. Keller, M. Wilm, M.W. Hentze, A.E. Kulozik.EMBO J.<\/em> 2007 Jun 6;26(11):2658-69. Epub 2007 Apr 26.<\/p>\n\n\n\n

All publications in PubMed<\/a><\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\nGroup members<\/summary>\n
\n\n

Christopher Carnie, PhD<\/strong>
Group Leader
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology; Children\u2019s Hospital; Heidelberg University Medical Center
ChristopherJames.Carnie@med.uni-heidelberg.de<\/a><\/p>\n\n\n\n

Nicole Dickemann<\/strong>
Technician
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology; Children\u2019s Hospital; Heidelberg University Medical Center
Phone: +49 6221 564579 
nicole.dickemann@med.uni-heidelberg.de<\/a><\/p>\n\n\n\n

Yimin Du<\/strong>
PhD student
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology; Children\u2019s Hospital; Heidelberg University Medical Center
Yimin.Du@med.uni-heidelberg.de<\/a><\/p>\n\n\n\n

Manouk Gerritsen<\/strong>
PhD Student (EMBL International PhD Programme \u2013 EIPP)
Hentze Group
manouk.gerritsen@embl.de<\/a><\/p>\n\n\n\n

Muna Haidary<\/strong>
MD student
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology; Children\u2019s Hospital; Heidelberg University Medical Center
Phone: +49 6221 564584
muna.haidary@stud.uni-heidelberg.de<\/a> <\/p>\n\n\n\n

Margit Happich<\/strong>
Technician
Department of Pediatric Oncology, Hematology, Immunology and Pulmonology; Children\u2019s Hospital; Heidelberg University Medical Center
Phone: +49 6221 564584
margit.happich@med.uni-heidelberg.de<\/a><\/p>\n\n\n\n

Om Rathore, PhD<\/strong>
Senior Postdoc
Hentze Group
om.rathore@embl.de<\/a> <\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\nFormer members<\/summary>\n
\n\n

Beate Amthor<\/strong>, Technician<\/strong><\/p>\n\n\n\n

Michael Backlund, PhD<\/strong><\/p>\n\n\n\n

Jonas Becker, PhD<\/strong>

Stephanie B\u00f6lz, PhD<\/strong><\/p>\n\n\n\n

Stephen Breit<\/strong>, PhD<\/strong>
breit@zhma.de<\/a><\/p>\n\n\n\n

Madhuri Bhuvanagiri, PhD<\/strong><\/p>\n\n\n\n

Annika Brosig<\/strong>, PhD<\/strong><\/p>\n\n\n\n

Sven Danckwardt, MD<\/strong>
Head of the Professorship Laboratory Medicine and Experimental Hemostasis, Center for Thrombosis and Hemostasis (CTH), University Medical Center, Mainz
sven.danckwardt@unimedizin-mainz.de<\/a><\/p>\n\n\n\n

Raga Ediga<\/strong><\/p>\n\n\n\n

Anne-Susan Gantzert, PhD<\/strong><\/p>\n\n\n\n

Niels Gehring, PhD<\/strong>
Group Leader \u2013 Institute for Genetics, University of Cologne
ngehring@uni-koeln.de<\/a><\/p>\n\n\n\n

Claudia Gruber, PhD<\/strong>, MD student<\/p>\n\n\n\n

Kerstin Grund, MD<\/strong><\/p>\n\n\n\n

Christian Hauer, PhD<\/strong><\/p>\n\n\n\n

Jill Holbrook, MD, PhD<\/strong><\/p>\n\n\n\n

Ina Hollerer, PhD<\/strong><\/p>\n\n\n\n

Pavel Ivanov, PhD<\/strong><\/p>\n\n\n\n

Klodiana Jani<\/strong>, PhD<\/strong><\/p>\n\n\n\n

Kathrin Kerschgens, PhD<\/strong><\/p>\n\n\n\n

Corinne Kox, PhD<\/strong><\/p>\n\n\n\n

Stella Lamprinaki, PhD<\/strong><\/p>\n\n\n\n

Daria Lavysh, PhD<\/strong><\/p>\n\n\n\n

Mandy Medenhoff, Technician<\/strong><\/p>\n\n\n\n

Lena Muckenthaler<\/strong>, MD student (JCF\/HRCMM)<\/p>\n\n\n\n

Gabriele Neu-Yilik, PhD<\/strong>
Privatdozentin, Staff Scientist<\/p>\n\n\n\n

Partho Ray, PhD<\/strong>
Postdoc<\/p>\n\n\n\n

Anna Melissa Schlitter, MD<\/strong>
Resident in Pathology \u2013 Department of Pathology, Technische Universit\u00e4t M\u00fcnchen, Germany
melissa.schlitter@lrz.tu-muenchen.de<\/a><\/p>\n\n\n\n

Jana Sieber, PhD<\/strong>

Gabriele Tolle<\/strong>, Technician<\/p>\n\n\n\n

Marcelo Viegas, PhD<\/strong>
Senior Scientist and Project Leader \u2013 R&D Department
Progenika Biopharma S.A.
mviegas@progenika.com<\/a><\/p>\n\n\n\n

Yang Zhou, PhD<\/strong>
Postdoc<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

<\/div>\n\n<\/div>\n<\/div>\n\n\n
\n
\n\n
\n \n
\n

\n \n On this page\n <\/h3>\n \n \n

    \r\n \t
  • Our research interest<\/li>\r\n \t
  • Background<\/li>\r\n \t
  • Goals<\/li>\r\n \t
  • Join us!<\/li>\r\n \t
  • Selected publications<\/li>\r\n \t
  • Group members<\/li>\r\n \t
  • Former members<\/li>\r\n<\/ul><\/p>\n <\/div>\n<\/article>\n\n\n\n
    \"\"
    Matthias Hentze and Andreas Kulozik<\/figcaption><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":56,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-93","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/pages\/93","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/comments?post=93"}],"version-history":[{"count":30,"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/pages\/93\/revisions"}],"predecessor-version":[{"id":16537,"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/pages\/93\/revisions\/16537"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/pages\/56"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/media?parent=93"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/mmpu\/wp-json\/wp\/v2\/embl_taxonomy?post=93"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}