{"id":77,"date":"2020-10-27T16:08:34","date_gmt":"2020-10-27T16:08:34","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/mmpu\/?page_id=77"},"modified":"2026-03-24T15:42:57","modified_gmt":"2026-03-24T15:42:57","slug":"recent-publications","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/mmpu\/recent-publications\/","title":{"rendered":"Recent publications"},"content":{"rendered":"\n
\n
\n\n
\n\n2025<\/summary>\n
\n\n

Origins of chromosome instability unveiled by coupled imaging and genomics.<\/a>
Cosenza MR, Gaiatto A, Erarslan Uysal B, Andrades \u00c1, Sautter NL, Simunovic M, Jendrusch MA, Zumalave S, Rausch T, Halavatyi A, Geissen EM, Eigenmann JL, Weber T, Hasenfeld P, Benito E, Stober C, Cortes-Ciriano I, Kulozik AE, Pepperkok R, Korbel JO.
Nature. 2025 Dec;648(8093):383-393. doi: 10.1038\/s41586-025-09632-5. Epub 2025 Oct 29.PMID: 41162705<\/p>\n\n\n\n

Accumulation of Lymphoid Progenitors with Defective B Cell Differentiation and of Putative Natural Killer Progenitors in Aging Human Bone Marrow.<\/a>
Poisa-Beiro L, Landry JJM, Cherdintsev A, Kardorff M, Eckstein V, Villacorta L, Zaugg J, Gavin AC, Benes V, Raffel S, Ho AD.
Int J Mol Sci. 2025 Oct 28;26(21):10467. doi: 10.3390\/ijms262110467.PMID: 41226506<\/p>\n\n\n\n

Functional phenotyping of genomic variants using joint multiomic single-cell DNA-RNA sequencing<\/a>.
Lindenhofer D, Bauman JR, Hawkins JA, Fitzgerald D, Yildiz U, Jung H, Korosteleva A, Marttinen M, Kueblbeck M, Zaugg JB, Noh KM, Dietrich S, Huber W, Stegle O, Steinmetz LM.
Nat Methods. 2025 Oct;22(10):2032-2041. doi: 10.1038\/s41592-025-02805-0. Epub 2025 Sep 1. PMID: 40890552<\/p>\n\n\n\n

Three-photon microscopy: an emerging technique for deep intravital brain imaging.<\/a>
Prevedel R, Ferrer Ortas J, Kerr JND, Waters J, Breckwoldt MO, Deneen B, Monje M, Soyka SJ, Venkataramani V.
Nat Rev Neurosci. 2025 Sep;26(9):521-537. doi: 10.1038\/s41583-025-00937-y. Epub 2025 Jun 20.PMID: 40542182<\/p>\n\n\n\n

Combined MEK and PARP inhibition enhances radiation response in rectal cancer<\/a>.
Xiao Q, Riedesser JE, Mulholland T, Li Z, Buchloh J, Albrecht P, Yang X, Li M, Venkatachalam N, Skabkina O, Klupsch A, Eichhorn E, Wang L, Belle S, Schulte N, Schmitz D, Froelich MF, Trikhirhisthit K, Valentini E, Boonekamp KE, Petersen Y, Miersch T, Burgermeister E, Herskind C, Veldwijk MR, Brochhausen C, Ihnatko R, Krijgsveld J, Kurth I, Zhu Y, Ma Y, Cao K, Boutros M, Ebert MP, Zhan T, Betge J.
Cell Rep Med. 2025 Aug 19;6(8):102284. doi: 10.1016\/j.xcrm.2025.102284. Epub 2025 Aug 8.PMID: 40782795<\/p>\n\n\n\n

Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia.<\/a>
Costea J, Rauwolf KK, Zafferani P, Rausch T, Mathioudaki A, Zaugg J, Schrappe M, Eckert C, Escherich G, Bourquin JP, Bornhauser B, Kulozik AE, Korbel JO.
Nat Commun. 2025 Jun 27;16(1):5413. doi: 10.1038\/s41467-025-61222-1.PMID: 40579412<\/p>\n\n\n\n

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics.<\/a>
Lobato-Moreno S, Yildiz U, Claringbould A, Servaas NH, Vlachou EP, Arnold C, Bauersachs HG, Campos-Forn\u00e9s V, Kim M, Berest I, Prummel KD, Noh KM, Marttinen M, Zaugg JB.
Nat Methods. 2025 Jun;22(6):1213-1225. doi: 10.1038\/s41592-025-02700-8. Epub 2025 May 26.PMID: 40419657<\/p>\n\n\n\n

Spatialproteomics – an interoperable toolbox for analyzing highly multiplexed fluorescence image data<\/a>.
Matthias Meyer-Bender, Harald V\u00f6hringer, Christina Schniederjohann, Sarah Koziel, Erin Chung, Ekaterina Popova, Alexander Brobeil, Lisa-Maria Held, Aamir Munir, Scverse Community, Sascha Dietrich, Peter-Martin Bruch, and Wolfgang Huber.
bioR\u03c7iv<\/em>, May 2025.
DOI:10.1101\/2025.04.29.651202<\/a> – Preprint<\/a> – EuropePMC<\/a>.<\/p>\n\n\n\n

IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.<\/a>
Pohly MF, Putzker K, Scheinost S, Ben Taarit L, Walther T, Kummer S, Wertheimer T, Lin M, Do THL, Handler K, Michler J, Kivioja J, Bach K, Kisele S, Kim J, Dietrich S, Bornhauser B, Wong WW, Becher B, Moor A, Lewis J, Ficht X, Lu J, Huber W, <\/strong>Zenz T.
Blood. 2025 May 15;145(20):2336-2352. doi: 10.1182\/blood.2024027171. PMID: 39869826<\/p>\n\n\n\n

Phosphatidic acid phosphatase LPIN1 in phospholipid metabolism and stemness in hematopoiesis and AML.<\/a>
Huber K, Garg S, Schlautmann L, Wang R, He L, Huth R, Pouya A, Rohde C, Janssen M, L\u00fcchtenborg C, Arnold C, Luque-Navarro PM, Zaugg JB, Raffel S, M\u00fcller-Tidow C, Jeremias I, L\u00f3pez-Cara LC, Br\u00fcgger B, Pabst C.
Hemasphere. 2025 Apr 22;9(4):e70118. doi: 10.1002\/hem3.70118. eCollection 2025 Apr.PMID: 40265168<\/p>\n\n\n\n

Subclonal TP53 and KRAS variants combined with poor treatment response identify ultrahigh-risk pediatric patients with T-ALL.<\/a>
Kempter T, Richter-Pecha\u0144ska P, Michel K, Rausch T, Erarslan-Uysal B, Eckert C, Zimmermann M, Stanulla M, Schrappe M, Cario G, K\u00f6hrer S, Attarbaschi A, Korbel JO, Kunz JB, Kulozik AE.
Blood Adv. 2025 Mar 25;9(6):1267-1279. doi: 10.1182\/bloodadvances.2024014209.PMID: 39808796<\/p>\n\n\n\n

Blocking the CD39\/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphoma.<\/a>
Kolbe C, Kauer J, Brinkmann B, Dreger P, Huber W, M\u00fcller-Tidow C, Dietrich S, Roider T. J
Immunother Cancer. 2025 Jan 30;13(1):e009245. doi: 10.1136\/jitc-2024-009245. PMID: 39884778<\/p>\n\n\n\n

SpatialData: an open and universal data framework for spatial omics.<\/a>
Marconato L, Palla G, Yamauchi KA, Virshup I, Heidari E, Treis T, Vierdag WM, Toth M, Stockhaus S, Shrestha RB, Rombaut B, Pollaris L, Lehner L, V\u00f6hringer H, Kats I, Saeys Y, Saka SK, Huber W, Gerstung M, Moore J, Theis FJ, Stegle O.
Nat Methods. 2025 Jan;22(1):58-62. doi: 10.1038\/s41592-024-02212-x. Epub 2024 Mar 20. PMID: 38509327<\/p>\n\n\n\n

A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy.<\/a>
Poisa-Beiro L, Landry JJM, Yan B, Kardorff M, Eckstein V, Villacorta L, Krammer PH, Zaugg J, Gavin AC, Benes V, Zhou D, Raffel S, Ho AD.
Int J Mol Sci. 2025 Jan 17;26(2):787. doi: 10.3390\/ijms26020787.PMID: 39859500<\/p>\n\n\n\n

Multiplexed Immunophenotyping of Lymphoma Tissue Samples<\/a>.
Schniederjohann C, Bruch PM, Dietrich S, Neumann F.
Methods Mol Biol. 2025;2865:375-393. doi: 10.1007\/978-1-0716-4188-0_16.PMID: 39424733<\/p>\n\n\n\n

Digestive cancers: mechanisms, therapeutics and management<\/a>.
Zhan T, Betge J, Schulte N, Dreikhausen L, Hirth M, Li M, Weidner P, Leipertz A, Teufel A, Ebert MP.
Signal Transduct Target Ther. 2025 Jan 15;10(1):24. doi: 10.1038\/s41392-024-02097-4.PMID: 39809756<\/a><\/p>\n\n\n\n

Depletion of macrophages and osteoclast precursors mitigates iron overload-mediated bone loss.<\/a>
Passin V, Ledesma-Colunga MG, Altamura S, Muckenthaler MU, Baschant U, Hofbauer LC, Rauner M.
IUBMB Life. 2025 Jan;77(1):e2928. doi: 10.1002\/iub.2928. Epub 2024 Nov 18.PMID: 39555707<\/a><\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2024<\/summary>\n
\n\n

Inflammation-driven NF\u03baB signaling represses Ferroportin transcription in macrophages via HDAC 1 and 3.<\/a>
Marques O, Horvat NK, Zechner L, Colucci S, Sparla R, Zimmermann S, Neufeldt CJ, Altamura S, Qiu R, M\u00fcdder K, Weiss G, Hentze MW, Muckenthaler MU.
Blood. 2024 Dec 10:blood.2023023417. doi: 10.1182\/blood.2023023417. Online ahead of print.PMID: 39656097<\/a><\/p>\n\n\n\n

Aggressive Lymphoma after CD19 CAR T-Cell Therapy<\/a>.
Kobbe G, Br\u00fcggemann M, Baermann BN, Wiegand L, Trautmann H, Yousefian S, Libertini S, Menssen HD, Maier HJ, Ulrich P, Gao J, Bruch PM, Liebers N, Radujkovic A, Seifert M, Schniederjohann C, Paramasivam N, Fitzgerald D, Seidel M, Esposito I, Germing U, Cadeddu RP, Nachtkamp K, J\u00e4ger P, Ulrych T, Fischer JC, Rox JM, Giesel F, Koch R, Antoch G, Distler JHW, Meuth SG, Jacobsen M, H\u00fcbschmann D, Lu J, Iaccarino I, Haas S, Damm F, Dietrich S.
N Engl J Med. 2024 Oct 3;391(13):1217-1226. doi: 10.1056\/NEJMoa2402730.PMID: 39589371<\/p>\n\n\n\n

Deep intravital brain tumor imaging enabled by tailored three-photon microscopy and analysis.<\/a>
Schubert MC, Soyka SJ, Tamimi A, Maus E, Schroers J, Wi\u00dfmann N, Reyhan E, Tetzlaff SK, Yang Y, Denninger R, Peretzke R, Beretta C, Drumm M, Heuer A, Buchert V, Steffens A, Walshon J, McCortney K, Heiland S, Bendszus M, Neher P, Golebiewska A, Wick W, Winkler F, Breckwoldt MO, Kreshuk A, Kuner T, Horbinski C, Kurz FT, Prevedel R, Venkataramani V.
Nat Commun. 2024 Sep 10;15(1):7383. doi: 10.1038\/s41467-024-51432-4.PMID: 39256378<\/p>\n\n\n\n

Iron scavenging and myeloid cell polarization.<\/a>
Ludwig N, Cucinelli S, Hametner S, Muckenthaler MU, Schirmer L.
Trends Immunol. 2024 Aug;45(8):625-638. doi: 10.1016\/j.it.2024.06.006. Epub 2024 Jul 24.PMID: 39054114<\/p>\n\n\n\n

Thermally-induced neuronal plasticity that mediates heat tolerance<\/a>. <\/em>
Wojciech Ambroziak, Sara Nencini, J\u00f6rg Pohle, Kristina Zuza, Gabriela Pino, Sofia Lundh, Carolina Araujo-Sousa, Larissa I. L. Goetz, Katrin Schrenk-Siemens, Gokul Manoj, Mildred A. Herrera, Claudio Acuna & Jan Siemens.
2024, bioRxiv, Aug 8. doi: 10.1101\/2024.08.06.6069291<\/p>\n\n\n\n

Gut microbiota carcinogen metabolism causes distal tissue tumours.<\/a>
Roje B, Zhang B, Mastrorilli E, Kova\u010di\u0107 A, Su\u0161ak L, Ljubenkov I, \u0106osi\u0107 E, Vilovi\u0107 K, Me\u0161trovi\u0107 A, Vukovac EL, Bu\u010devi\u0107-Popovi\u0107 V, Puljiz \u017d, Karaman I, Terzi\u0107 J, Zimmermann M.
Nature. 2024 Jul 31. doi: 10.1038\/s41586-024-07754-w. PMID: 39085612<\/p>\n\n\n\n

Recommendations for diagnosis, treatment, and prevention of iron deficiency and iron deficiency anemia.<\/a>
Iolascon A, Andolfo I, Russo R, Sanchez M, Busti F, Swinkels D, Aguilar Martinez P, Bou-Fakhredin R, Muckenthaler MU, Unal S, Porto G, Ganz T, Kattamis A, De Franceschi L, Cappellini MD, Munro MG, Taher A; from EHA\u2010SWG Red Cell and Iron.
Hemasphere. 2024 Jul 15;8(7):e108. doi: 10.1002\/hem3.108. eCollection 2024 Jul.PMID: 39011129<\/p>\n\n\n\n

Unveiling the culprit: the fusobacterium lineage that populates colorectal cancer.<\/a>
Betge J, Ebert MP.
Signal Transduct Target Ther. 2024 May 8;9(1):122. doi: 10.1038\/s41392-024-01844-x.PMID: 38719840<\/p>\n\n\n\n

Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment.<\/a>
Horvat NK, Chocarro S, Marques O, Bauer TA, Qiu R, Diaz-Jimenez A, Helm B, Chen Y, Sawall S, Sparla R, Su L, Klingm\u00fcller U, Barz M, Hentze MW, Sotillo R, Muckenthaler MU.
ACS Nano. 2024 Apr 30;18(17):11025-11041. doi: 10.1021\/acsnano.3c08335. Epub 2024 Apr 16.PMID: 38626916<\/p>\n\n\n\n

An Intra-Hypothalamic Pathway Modulating Body Temperature and Feeding<\/a>.
Sara Nencini & Jan Siemens.
2024, bioRxiv, Apr 16. doi: 10.1101\/2024.04.16.5896861<\/p>\n\n\n\n

Reversible Host-Guest Crosslinks in Supramolecular Hydrogels for On-Demand Mechanical Stimulation of Human Mesenchymal Stem Cells.<\/a>
Linke P, Munding N, Kimmle E, Kaufmann S, Hayashi K, Nakahata M, Takashima Y, Sano M, Bastmeyer M, Holstein T, Dietrich S, M\u00fcller-Tidow C, Harada A, Ho AD, Tanaka M.
Adv Healthc Mater. 2024 Apr;13(10):e2302607. doi: 10.1002\/adhm.202302607. Epub 2023 Dec 25.PMID: 38118064<\/p>\n\n\n\n

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.<\/a>
Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE.
Nat Commun. 2024 Apr 1;15(1):2810. doi: 10.1038\/s41467-024-47031-y.PMID: 38561347<\/p>\n\n\n\n

Alterations of iron homeostasis as a potential druggable driver of long COVID.<\/a>
Marques O, Muckenthaler MU.
Nat Immunol. 2024 Mar;25(3):387-389. doi: 10.1038\/s41590-024-01759-3.PMID: 38429459<\/p>\n\n\n\n

Neuron\u2013astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain<\/a>
Sebasti\u00e1n Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna A. DePaoli-Roach, Anna M. Hagenston, Hagen Wende, Anke Tappe-Theodor, Manuela Simonetti, Hilmar Bading, J\u00fcrgen G. Okun, Rohini Kuner, Thomas Fleming & Jan Siemens
Nature Metabolism (2024) March 5, doi<\/a>:10.1038\/s42255-024-01001-2<\/a><\/em><\/p>\n\n\n\n

Multimodal and spatially resolved profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities<\/a>.
Tobias Roider, Marc A. Baertsch, Donnacha Fitzgerald, Harald V\u00f6hringer, Berit J. Brinkmann, Felix Czernilofsky, Mareike Knoll, Laura Lla\u00f3-Cid, Peter-Martin Bruch, Nora Liebers, Christian M. Sch\u00fcrch, Verena Passerini, Alexander Brobeil, Gunhild Mechtersheimer, Carsten M\u00fcller-Tidow, Oliver Weigert, Martina Seiffert, Garry P. Nolan, Wolfgang Huber, and Sascha Dietrich
Nature Cell Biology<\/em> 2024, Feb 20 volume 26, pages 478\u2013489, DOI:10.1038\/s41556-024-01358-<\/a><\/p>\n\n\n\n

The remission status of AML patients post alloSCT is associated with a distinct single-cell bone marrow T cell signature.<\/a>
Mathioudaki A, Wang X, Sedloev DN, Huth R, Kamal A, Hundemer M, Liu Y, Vasileiou S, Lulla PD, M\u00fcller-Tidow C, Dreger P, Luft T, Sauer T, Schmitt M, Zaugg JB, Pabst C.
Blood. 2024 Jan 9:blood.2023021815. doi: 10.1182\/blood.2023021815. Online ahead of print.PMID: 38197505<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2023<\/summary>\n
\n\n

The relevance of the hematopoietic niche for therapy resistance in acute myeloid leukemia.<\/a>
Allert C, M\u00fcller-Tidow C, Blank MF.
Int J Cancer. 2024 Jan 15;154(2):197-209. doi: 10.1002\/ijc.34684. Epub 2023 Aug 11.PMID: 37565773<\/p>\n\n\n\n

The landscape of small nucleolar RNA expression in multiple myeloma is determined by cytogenetic alterations.<\/a>
Zhao D, Rohde C, G\u00f6llner S, Zhou F, Pauli C, Blank MF, Zinz R, Grab AL, Poos AM, John L, Huhn S, Raab MS, M\u00fcller-Tidow C, Weinhold N.
Leukemia. 2023 Dec;37(12):2526-2531. doi: 10.1038\/s41375-023-02060-2. Epub 2023 Oct 16.PMID: 37845284<\/p>\n\n\n\n

Stem cell collection after lenalidomide, bortezomib and dexamethasone plus elotuzumab or isatuximab in newly diagnosed multiple myeloma patients: a single centre experience from the GMMG-HD6 and -HD7 trials.<\/a>
Kauer J, Freundt EP, Schmitt A, Weinhold N, Mai EK, M\u00fcller-Tidow C, Goldschmidt H, Raab MS, Kriegsmann K, Sauer S.
BMC Cancer. 2023 Nov 21;23(1):1132. doi: 10.1186\/s12885-023-11507-9.PMID: 37990162<\/p>\n\n\n\n

A single-cell multi-omic and spatial atlas of B cell lymphomas reveals differentiation drives intratumor heterogeneity.<\/a>
Donnacha Fitzgerald, Tobias Roider, Marc-Andrea Baertsch, Artur Kibler, Anastasiia Horlova, Erin Chung, Harald V\u00f6hringer, Anna Mathioudaki, Bettina Budeus, Verena Passerini, Mareike Knoll, Johannes Mammen, Linsha Li, L\u00e9andra Caill\u00e9, Felix Czernilofsky, Peter-Martin Bruch, Nora Liebers, Matthias Meyer-Bender, Oliver Weigert, Judith Zaugg, Garry Nolan, Marc Seifert, Sascha Dietrich, and Wolfgang Huber.
bioR\u03c7iv<\/em>, 2023. DOI:10.1101\/2023.11.06.565756 \u2013 Preprint<\/a> \u2013 EuropePMC<\/a>.<\/p>\n\n\n\n

Iron homeostasis in mice: does liver lobe matter?<\/a>
Colucci S, Carvalho Oliveira T, Muckenthaler MU, Marques O.
Am J Physiol Gastrointest Liver Physiol. 2023 Nov 1;325(5):G453-G457. doi: 10.1152\/ajpgi.00085.2023. Epub 2023 Sep 5.PMID: 37667844<\/p>\n\n\n\n

Dominantly inherited micro-satellite instable cancer – the four Lynch syndromes – an EHTG, PLSD position statement.<\/a>
M\u00f8ller P, Sepp\u00e4l\u00e4 TT, Ahadova A, Crosbie EJ, Holinski-Feder E, Scott R, Haupt S, M\u00f6slein G, Winship I, Broeke SWB, Kohut KE, Ryan N, Bauerfeind P, Thomas LE, Evans DG, Aretz S, Sijmons RH, Half E, Heinimann K, Horisberger K, Monahan K, Engel C, Cavestro GM, Fruscio R, Abu-Freha N, Zohar L, Laghi L, Bertario L, Bonanni B, Tibiletti MG, Lino-Silva LS, Vaccaro C, Valle AD, Rossi BM, da Silva LA, de Oliveira Nascimento IL, Rossi NT, D\u0119bniak T, Mecklin JP, Bernstein I, Lindblom A, Sunde L, Nakken S, Heuveline V, Burn J, Hovig E, Kloor M, Sampson JR, Dominguez-Valentin M; Prospective Lynch Syndrome Database (www.plsd.eu) and The European Hereditary Tumour Group (www.ehtg.org).
Hered Cancer Clin Pract. 2023 Oct 11;21(1):19. doi: 10.1186\/s13053-023-00263-3.PMID: 37821984<\/p>\n\n\n\n

Ex vivo drug response profiling for response and outcome prediction in hematologic malignancies: the prospective non-interventional SMARTrial.<\/a>
Liebers N, Bruch PM, Terzer T, Hernandez-Hernandez M, Paramasivam N, Fitzgerald D, Altmann H, Roider T, Kolb C, Knoll M, Lenze A, Platzbecker U, R\u00f6llig C, Baldus C, Serve H, Bornh\u00e4user M, H\u00fcbschmann D, M\u00fcller-Tidow C, St\u00f6lzel F, Huber W, Benner A, Zenz T, Lu J, Dietrich S.
Nat Cancer. 2023 Oct 2. doi: 10.1038\/s43018-023-00645-5. Online ahead of print.PMID: 37783805<\/p>\n\n\n\n

FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes.<\/a>
Pettinato M, Dulja A, Colucci S, Furiosi V, Fette F, Steinbicker AU, Muckenthaler MU, Nai A, Pagani A, Silvestri L.
Am J Hematol. 2023 Aug;98(8):1223-1235. doi: 10.1002\/ajh.26961. Epub 2023 May 18.PMID: 37199280<\/p>\n\n\n\n

The ribosomal protein S6 kinase alpha-1 (RPS6KA1) induces resistance to venetoclax\/azacitidine in acute myeloid leukemia.<\/a>
Weidenauer K, Schmidt C, Rohde C, Pauli C, Blank MF, Heid D, Waclawiczek A, Corbacioglu A, G\u00f6llner S, Lotze M, Vierbaum L, Renders S, Krijgsveld J, Raffel S, Sauer T, Trumpp A, Pabst C, M\u00fcller-Tidow C, Janssen M.
Leukemia. 2023 Aug;37(8):1611-1625. doi: 10.1038\/s41375-023-01951-8. Epub 2023 Jul 6.PMID: 37414921<\/p>\n\n\n\n

Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies<\/a>
Sophie A. Herbst, Vladislav Kim, Tobias Roider, Eva C. Schitter, Peter-Martin Bruch, Nora Liebers, Carolin Kolb, Mareike Knoll, Junyan Lu, Peter Dreger, Carsten M\u00fcller-Tidow, Thorsten Zenz, Wolfgang Huber, Sascha Dietrich
Blood advances June 23, 2023  https:\/\/doi.org\/10.1182\/bloodadvances.2022009652<\/p>\n\n\n\n

Association Between Ferritin Levels and Altitude-Dependent Cardiorespiratory Fitness in Mountain Guides.<\/a>
P\u00fchringer R, Muckenthaler M, Burtscher M.
High Alt Med Biol. 2023 Jun;24(2):139-143. doi: 10.1089\/ham.2023.0016. Epub 2023 May 3.PMID: 37134197<\/p>\n\n\n\n

Functional analysis of structural variants in single cells using Strand-seq.<\/a>
Jeong H, Grimes K, Rauwolf KK, Bruch PM, Rausch T, Hasenfeld P, Benito E, Roider T, Sabarinathan R, Porubsky D, Herbst SA, Erarslan-Uysal B, Jann JC, Marschall T, Nowak D, Bourquin JP, Kulozik AE, Dietrich S, Bornhauser B, Sanders AD, Korbel JO.
Nat Biotechnol. 2023 Jun;41(6):832-844. doi: 10.1038\/s41587-022-01551-4. Epub 2022 Nov 24.PMID: 36424487<\/p>\n\n\n\n

Physical biomarkers for human hematopoietic stem and progenitor cells.<\/a>
Tanaka M, Thoma J, Poisa-Beiro L, Wuchter P, Eckstein V, Dietrich S, Pabst C, M\u00fcller-Tidow C, Ohta T, Ho AD.
Cells Dev. 2023 Jun;174:203845. doi: 10.1016\/j.cdev.2023.203845. Epub 2023 Apr 26.PMID: 37116713<\/p>\n\n\n\n

Prefrontal engrams of long-term fear memory perpetuate pain perception.<\/a>
Stegemann A, Liu S, Retana Romero OA, Oswald MJ, Han Y, Beretta CA, Gan Z, Tan LL, Wisden W, Gr\u00e4ff J, Kuner R.<\/strong>
Nat Neurosci. 2023 May;26(5):820-829. doi: 10.1038\/s41593-023-01291-x. Epub 2023 Apr 6. PMID: 37024573<\/p>\n\n\n\n

High-resolution line-scan Brillouin microscopy for live imaging of mechanical properties during embryo development.<\/a>
Bevilacqua C, Gomez JM, Fiuza UM, Chan CJ, Wang L, Hambura S, Eguren M, Ellenberg J, Diz-Mu\u00f1oz A, Leptin M, Prevedel R.
Nat Methods. 2023 May;20(5):755-760. doi: 10.1038\/s41592-023-01822-1. Epub 2023 Mar 30.PMID: 36997817<\/p>\n\n\n\n

Autologous Stem Cell Collection after Daratumumab, Bortezomib, Thalidomide, and Dexamethasone versus Bortezomib, Cyclophosphamide, and Dexamethasone in Newly Diagnosed Multiple Myeloma.<\/a>
Sauer S, Kriegsmann K, Nientiedt C, Schmitt A, M\u00fcller-Tidow C, Raab MS, Kauer J.
Transfus Med Hemother. 2023 Mar 24;50(5):371-381. doi: 10.1159\/000529691. eCollection 2023 Oct.PMID: 37936633<\/p>\n\n\n\n

A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.<\/a>
Zhou F, Aroua N, Liu Y, Rohde C, Cheng J, Wirth AK, Fijalkowska D, G\u00f6llner S, Lotze M, Yun H, Yu X, Pabst C, Sauer T, Oellerich T, Serve H, R\u00f6llig C, Bornh\u00e4user M, Thiede C, Baldus C, Frye M, Raffel S, Krijgsveld J, Jeremias I, Beckmann R, Trumpp A, M\u00fcller-Tidow C.
Cancer Discov. 2023 Feb 6;13(2):332-347. doi: 10.1158\/2159-8290.CD-22-0210.PMID: 36259929<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2022<\/summary>\n
\n\n

Layer-specific pain relief pathways originating from primary motor cortex.<\/a>
Gan Z, Gangadharan V, Liu S, K\u00f6rber C, Tan LL, Li H, Oswald MJ, Kang J, Martin-Cortecero J, M\u00e4nnich D, Groh A, Kuner T, Wieland S, Kuner R.
Science. 2022 Dec 23;378(6626):1336-1343. doi: 10.1126\/science.add4391. Epub 2022 Dec 22. PMID: 36548429<\/p>\n\n\n\n

Venetoclax synergizes with gilteritinib in FLT3 wild-type high-risk acute myeloid leukemia by suppressing MCL-1.<\/a>
Janssen M, Schmidt C, Bruch PM, Blank MF, Rohde C, Waclawiczek A, Heid D, Renders S, G\u00f6llner S, Vierbaum L, Besenbeck B, Herbst SA, Knoll M, Kolb C, Przybylla A, Weidenauer K, Ludwig AK, Fabre M, Gu M, Schlenk RF, St\u00f6lzel F, Bornh\u00e4user M, R\u00f6llig C, Platzbecker U, Baldus C, Serve H, Sauer T, Raffel S, Pabst C, Vassiliou G, Vick B, Jeremias I, Trumpp A, Krijgsveld J, M\u00fcller-Tidow C, Dietrich S.
Blood. 2022 Dec 15;140(24):2594-2610. doi: 10.1182\/blood.2021014241.PMID: 35857899<\/p>\n\n\n\n

Repression of the iron exporter ferroportin may contribute to hepatocyte iron overload in individuals with type 2 diabetes.<\/a>
Qiu R, Alikhanyan K, Volk N, Marques O, Mertens C, Agarvas AR, Singh S, Pepperkok R, Altamura S, Muckenthaler MU.
Mol Metab. 2022 Dec;66:101644. doi: 10.1016\/j.molmet.2022.101644. Epub 2022 Nov 24.PMID: 36436807<\/p>\n\n\n\n

Neuron-astrocyte metabolic coupling facilitates spinal plasticity and maintenance of persistent pain<\/a>.
Sebasti\u00e1n Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Hagen Wende, Katrin Schrenk-Siemens, Anna A. DePaoli-Roach, Anna M. Hagenston, Anke Tappe-Theodor, Manuela Simonetti, Rohini Kuner, Thomas Fleming & Jan Siemens.
bioRxiv, Dec 05. doi: 10.1101\/2022.12.03.518519<\/p>\n\n\n\n

Functional analysis of structural variants in single cells using Strand-seq.<\/a>
Jeong H, Grimes K, Rauwolf KK, Bruch PM, Rausch T, Hasenfeld P, Benito E, Roider T, Sabarinathan R, Porubsky D, Herbst SA, Erarslan-Uysal B, Jann JC, Marschall T, Nowak D, Bourquin JP, Kulozik AE, Dietrich S, Bornhauser B, Sanders AD, Korbel JO.
Nat Biotechnol. 2022 Nov 24. doi: 10.1038\/s41587-022-01551-4. Online ahead of print.PMID: 36424487<\/p>\n\n\n\n

Single-cell multi-omic and spatial analysis of nodal B cell non-Hodgkin lymphomas reveals plasticity in B cell maturation as a driver of intratumor heterogeneity<\/a>.
Donnacha Fitzgerald, Tobias Roider, Marc-A. Baertsch, Harald V\u00f6hringer, Mareike Knoll, Bettina Budeus, Artur Kibler, Anna Mathioudaki, L\u00e9andra Caill\u00e9, Linsha Li, Johannes Mammen, Marc Seifert, Wolfgang Huber, and Sascha Dietrich.
Blood, 140:742, November 2022. DOI:10.1182\/blood-2022-156210<\/p>\n\n\n\n

Multimodal and spatially resolved profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities<\/a>
Roider T, Marc A. Baertsch et al
bioRxiv Nov 8, 2022 <\/p>\n\n\n\n

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia.<\/a>
Herbst SA, Vesterlund M, Helmboldt AJ, Jafari R, Siavelis I, Stahl M, Schitter EC, Liebers N, Brinkmann BJ, Czernilofsky F, Roider T, Bruch PM, Iskar M, Kittai A, Huang Y, Lu J, Richter S, Mermelekas G, Umer HM, Knoll M, Kolb C, Lenze A, Cao X, \u00d6sterholm C, Wahnschaffe L, Herling C, Scheinost S, Ganzinger M, Mansouri L, Kriegsmann K, Kriegsmann M, Anders S, Zapatka M, Del Poeta G, Zucchetto A, Bomben R, Gattei V, Dreger P, Woyach J, Herling M, M\u00fcller-Tidow C, Rosenquist R, Stilgenbauer S, Zenz T, Huber W, Tausch E, Lehti\u00f6 J, Dietrich <\/strong>S.
Nat Commun. 2022 Oct 20;13(1):6226. doi: 10.1038\/s41467-022-33385-8.PMID: 36266272<\/p>\n\n\n\n

Protein tyrosine kinase 2b inhibition reverts niche-associated resistance to tyrosine kinase inhibitors in AML.<\/a>
Allert C, Waclawiczek A, Zimmermann SMN, G\u00f6llner S, Heid D, Janssen M, Renders S, Rohde C, Bauer M, Bruckmann M, Zinz R, Pauli C, Besenbeck B, Wickenhauser C, Trumpp A, Krijgsveld J, M\u00fcller-Tidow C, Blank MF.
Leukemia. 2022 Sep 2. doi: 10.1038\/s41375-022-01687-x. Online ahead of print. PMID: 36056084<\/p>\n\n\n\n

Inferring tumor-specific cancer dependencies through integrating ex vivo drug response assays and drug-protein profiling.<\/a>
Batzilla A, Lu J, Kivioja J, Putzker K, Lewis J, Zenz T, Huber W.
PLoS Comput Biol. 2022 Aug 22;18(8):e1010438. doi: 10.1371\/journal.pcbi.1010438. eCollection 2022 Aug.PMID: 35994503<\/p>\n\n\n\n

Genetic Mouse Models to Study Pancreatic Cancer-Induced Pain and Reduction in Well-Being.<\/a>
Hirth M, Xie Y, H\u00f6per C, Prats A, Hackert T, Ebert MP, Kuner R.
Cells. 2022 Aug 24;11(17):2634. doi: 10.3390\/cells11172634. PMID: 36078040<\/p>\n\n\n\n

The role of iron in chronic inflammatory diseases – from mechanisms to treatment options in Anemia of Inflammation.<\/a>
Marques O, Weiss G, Muckenthaler MU.
Blood. 2022 Aug 22:blood.2021013472. doi: 10.1182\/blood.2021013472. PMID: 35994752<\/p>\n\n\n\n

Drug-microenvironment perturbations reveal resistance mechanisms and prognostic subgroups in CLL.<\/a>
Bruch PM, Giles HA, Kolb C, Herbst SA, Becirovic T, Roider T, Lu J, Scheinost S, Wagner L, Huellein J, Berest I, Kriegsmann M, Kriegsmann K, Zgorzelski C, Dreger P, Zaugg JB, M\u00fcller-Tidow C, Zenz T, Huber W, Dietrich S.
Mol Syst Biol. 2022 Aug;18(8):e10855. doi: 10.15252\/msb.202110855. PMID: 35959629<\/p>\n\n\n\n

<\/a>Venetoclax synergizes with Gilteritinib in FLT3 wildtype high-risk Acute Myeloid Leukemia by suppressing MCL-1.<\/a>
Janssen M, Schmidt C, Bruch PM, Blank MF, Rohde C, Waclawiczek A, Heid D, Renders S, G\u00f6llner S, Vierbaum L, Besenbeck B, Herbst SA, Knoll M, Kolb C, Przybylla A, Weidenauer K, Ludwig AK, Fabre MA, Gu M, Schlenk RF, St\u00f6lzel F, Bornh\u00e4user M, R\u00f6llig C, Platzbecker U, Baldus CD, Serve H, Sauer T, Raffel S, Pabst C, Vassiliou GS, Vick B, Jeremias I, Trumpp A, Krijgsveld J, M\u00fcller-Tidow C, Dietrich S.
Blood. 2022 Jul 13:blood.2021014241. doi: 10.1182\/blood.2021014241. Online ahead of print. PMID: 35857899<\/p>\n\n\n\n

Neuropathic pain caused by miswiring and abnormal end organ targeting.<\/a>
Gangadharan V, Zheng H, Taberner FJ, Landry J, Nees TA, Pistolic J, Agarwal N, M\u00e4nnich D, Benes V, Helmstaedter M, Ommer B, Lechner SG, Kuner T, Kuner R.
Nature. 2022 Jun;606(7912):137-145. doi: 10.1038\/s41586-022-04777-z. Epub 2022 May 25. PMID: 35614217 <\/p>\n\n\n\n

Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.<\/a>
Richter-Pecha\u0144ska P, Kunz JB, Rausch T, Erarslan-Uysal B, Bornhauser B, Frismantas V, Assenov Y, Zimmermann M, Happich M, von Knebel-Doeberitz C, von Neuhoff N, K\u00f6hler R, Stanulla M, Schrappe M, Cario G, Escherich G, Kirschner-Schwabe R, Eckert C, Avigad S, Pfister SM, Muckenthaler MU, Bourquin JP, Korbel JO, Kulozik AE.
Leukemia. 2022 May 18. doi: 10.1038\/s41375-022-01587-0. Online ahead of print. PMID: 35585141<\/p>\n\n\n\n

Differential Analysis of the Nuclear and the Cytoplasmic RNA Interactomes in Living Cells.<\/a>
Backlund M, Kulozik AE.
Methods Mol Biol. 2022;2428:291-304. doi: 10.1007\/978-1-0716-1975-9_18. PMID: 35171487 <\/p>\n\n\n\n

Glucose Metabolism and Aging of Hematopoietic Stem and Progenitor Cells.<\/a>
Poisa-Beiro L, Landry JJM, Raffel S, Tanaka M, Zaugg J, Gavin AC, Ho AD.
Int J Mol Sci. 2022 Mar 11;23(6):3028. doi: 10.3390\/ijms23063028.PMID: 35328449<\/p>\n\n\n\n

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction.<\/a>
Muckenthaler L, Marques O, Colucci S, Kunz J, Fabrowski P, Bast T, Altamura S, H\u00f6chsmann B, Schrezenmeier H, Langlotz M, Richter-Pechanska P, Rausch T, Hofmeister-Mielke N, Gunkel N, Hentze MW, Kulozik AE, Muckenthaler MU.
Blood. 2022 Mar 3;139(9):1418-1422. doi: 10.1182\/blood.2021013519. PMID: 34875027<\/p>\n\n\n\n

<\/p>\n\n\n\n

<\/a><\/a>CDK7\/12\/13 inhibition targets an oscillating leukemia stem cell network and synergizes with venetoclax in acute myeloid leukemia.<\/a>
He L, Arnold C, Thoma J, Rohde C, Kholmatov M, Garg S, Hsiao CC, Viol L, Zhang K, Sun R, Schmidt C, Janssen M, MacRae T, Huber K, Thiede C, H\u00e9bert J, Sauvageau G, Spratte J, Fluhr H, Aust G, M\u00fcller-Tidow C, Niehrs C, Pereira G, Hamann J, Tanaka M, Zaugg JB, Pabst C.
EMBO Mol Med. 2022 Mar 7:e14990. doi: 10.15252\/emmm.202114990. Online ahead of print. PMID: 35253392<\/p>\n\n\n\n

<\/a>Inferring tumor-specific cancer dependencies through integrating ex-vivo drug response assays and drug-protein profiling<\/a>
Alina Batzilla, Junyan Lu, Jarno Kivioja, Kerstin Putzker, Joe Lewis, Thorsten Zenz, Wolfgang Huber
bioRxiv 2022.01.11.475864; doi: https:\/\/doi.org\/10.1101\/2022.01.11.475864<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2021<\/summary>\n
\n\n

Constitutional PIGA mutations cause a novel subtype of hemochromatosis in patients with neurologic dysfunction.<\/a>
Muckenthaler L, Marques O, Colucci S, Kunz JB, Fabrowski P, Bast T, Altamura S, H\u00f6chsmann B, Schrezenmeier H, Langlotz M, Richter-Pechanska P, Rausch T, Hofmeister-Mielke N, Gunkel N, Hentze MW, Kulozik AE, Muckenthaler MU.
Blood. 2021 Dec 7:blood.2021013519. doi: 10.1182\/blood.2021013519. PMID: 34875027<\/p>\n\n\n\n

Pairwise effects between lipid GWAS genes modulate lipid plasma levels and cellular uptake.<\/a>
Zimo\u0144 M, Huang Y, Trasta A, Halavatyi A, Liu JZ, Chen CY, Blattmann P, Klaus B, Whelan CD, Sexton D, John S, Huber W, Tsai EA, Pepperkok R, Runz H.
Nat Commun. 2021 Nov 5;12(1):6411. doi: 10.1038\/s41467-021-26761-3. PMID: 34741066 <\/p>\n\n\n\n

A synaptic temperature sensor for body cooling.<\/a>
Kamm GB, Boffi JC, Zuza K, Nencini S, Campos J, Schrenk-Siemens K, Sonntag I, Kabao\u011flu B, El Hay MYA, Schwarz Y, Tappe-Theodor A, Bruns D, Acuna C, Kuner T, Siemens J.
Neuron. 2021 Oct 20;109(20):3283-3297.e11. doi: 10.1016\/j.neuron.2021.10.001. PMID: 34672983<\/p>\n\n\n\n

Correction to ‘The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets’.<\/a>
Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, Jensen LJ, von Mering C.
Nucleic Acids Res. 2021 Sep 16:gkab835. doi: 10.1093\/nar\/gkab835. Online ahead of print. PMID: 34530444 <\/p>\n\n\n\n

High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy<\/a>.
Streich L, Boffi JC, Wang L, Alhalaseh K, Barbieri M, Rehm R, Deivasigamani S, Gross CT, Agarwal A, Prevedel R. Nat Methods. 2021 Sep 30. doi: 10.1038\/s41592-021-01257-6. Online ahead of print. PMID: 34594033<\/p>\n\n\n\n

Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia.<\/a>
Lu J, Cannizzaro E, Meier-Abt F, Scheinost S, Bruch PM, Giles HA, L\u00fctge A, H\u00fcllein J, Wagner L, Giacopelli B, Nadeu F, Delgado J, Campo E, Mangolini M, Ringshausen I, B\u00f6ttcher M, Mougiakakos D, Jacobs A, Bodenmiller B, Dietrich S, Oakes CC, Zenz T, Huber W.
Nat Cancer. 2021 Aug;2(8):853-864. doi: 10.1038\/s43018-021-00216-6. Epub 2021 Jul 1. PMID: 34423310<\/p>\n\n\n\n

The Macrophage Iron Signature in Health and Disease<\/a>
Christina Mertens, Oriana Marques, Natalie K. Horvat, Manuela Simonetti, Martina U. Muckenthaler and Michaela Jung
Int. J. Mol. Sci.<\/em>2021, 22<\/em>(16), 8457<\/p>\n\n\n\n

Mapping drug-microenvironment-genetic interplay in CLL reveals trisomy 12 as a modulator of microenvironmental signals
Peter-Martin Bruch, Holly A. R. Giles, Carolin Kolb, Sophie A. Herbst, Tina Becirovic, Tobias Roider, Junyan Lu, Sebastian Scheinost, Lena Wagner, Jennifer Huellein, Ivan Berest, Mark Kriegsmann, Katharina Kriegsmann, Christiane Zgorzelski, Peter Dreger, Judith B. Zaugg, Carsten M\u00fcller-Tidow, Thorsten Zenz, Wolfgang Huber, Sascha Dietrich
biorxiv July 29, 2021 https:\/\/doi.org\/10.1101\/2021.07.23.453514<\/a><\/p>\n\n\n\n

20 years of Hepcidin: How far we have come.<\/a>
Colucci S, Marques O, Altamura S.
Semin Hematol. 2021 Jul;58(3):132-144. doi: 10.1053\/j.seminhematol.2021.05.001. Epub 2021 Jun 12. PMID: 34389105<\/p>\n\n\n\n

SpaceM reveals metabolic states of single cells.<\/a>
Rappez L, Stadler M, Triana S, Gathungu RM, Ovchinnikova K, Phapale P, Heikenwalder M, Alexandrov T.
Nat Methods. 2021 Jul;18(7):799-805. doi: 10.1038\/s41592-021-01198-0. Epub 2021 Jul 5. PMID: 34226721<\/p>\n\n\n\n

Single-cell transcriptomics reveals immune response of intestinal cell types to viral infection.<\/a>
Triana S, Stanifer ML, Metz-Zumaran C, Shahraz M, Mukenhirn M, Kee C, Serger C, Koschny R, Ordo\u00f1ez-Rueda D, Paulsen M, Benes V, Boulant S, Alexandrov T.
Mol Syst Biol. 2021 Jul;17(7):e9833. doi: 10.15252\/msb.20209833. PMID: 34309190<\/p>\n\n\n\n

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.<\/a>
Powers KT, Stevenson-Jones F, Yadav SKN, Amthor B, Bufton JC, Borucu U, Shen D, Becker JP, Lavysh D, Hentze MW, Kulozik AE, Neu-Yilik G, Schaffitzel C.
Nucleic Acids Res. 2021 Jul 21;49(13):7665-7679. doi: 10.1093\/nar\/gkab532. PMID: 34157102<\/p>\n\n\n\n

Polatuzumab vedotin as a salvage and bridging treatment in relapsed or refractory large B-cell lymphomas.<\/a>
Liebers N, Duell J, Fitzgerald D, Kerkhoff A, Noerenberg D, Kaebisch E, Acker F, Fuhrmann S, Leng C, Welslau M, Chemnitz J, Middeke JM, Weber T, Holtick U, Trappe R, Pfannes R, Liersch R, Spoer C, Fuxius S, Gebauer N, Caill\u00e9 L, Geer T, Koenecke C, Keller U, Claus R, Mougiakakos D, Mayer S, Huettmann A, Pott C, Trummer A, Wulf G, Brunnberg U, Bullinger L, Hess G, Mueller-Tidow C, Glass B, Lenz G, Dreger P, Dietrich S.<\/strong>
Blood Adv. 2021 Jul 13;5(13):2707-2716. doi: 10.1182\/bloodadvances.2020004155. PMID: 34196677<\/p>\n\n\n\n

Core Cross-Linked Polymeric Micelles for Specific Iron Delivery: Inducing Sterile Inflammation in Macrophages.<\/a>
Bauer TA, Horvat NK, Marques O, Chocarro S, Mertens C, Colucci S, Schmitt S, Carrella LM, Morsbach S, Koynov K, Fenaroli F, Bl\u00fcmler P, Jung M, Sotillo R, Hentze MW, Muckenthaler MU, Barz M.
Adv Healthc Mater. 2021 Jun 16:e2100385. doi: 10.1002\/adhm.202100385. Online ahead of print. PMID: 34137217<\/p>\n\n\n\n

Coupling proteomics and metabolomics for the unsupervised identification of protein-metabolite interactions in Chaetomium thermophilum.<\/a>
Li Y, Kuhn M, Zukowska-Kasprzyk J, Hennrich ML, Kastritis PL, O’Reilly FJ, Phapale P, Beck M, Gavin AC, Bork P.
PLoS One. 2021 Jul 9;16(7):e0254429. doi: 10.1371\/journal.pone.0254429. eCollection 2021. PMID: 34242379 Free PMC article.<\/p>\n\n\n\n

Liver Sinusoidal Endothelial Cells Suppress Bone Morphogenetic Protein 2 Production in Response to TGF\u03b2 Pathway Activation.<\/a>
Colucci S, Altamura S, Marques O, Dropmann A, Horvat NK, M\u00fcdder K, Hammad S, Dooley S, Muckenthaler MU.
Hepatology. 2021 May 13. doi: 10.1002\/hep.31900. Online ahead of print. PMID: 33982327<\/p>\n\n\n\n

Deep learning-enhanced light-field imaging with continuous validation.
<\/a>Wagner N, Beuttenmueller F, Norlin N, Gierten J, Boffi JC, Wittbrodt J, Weigert M, Hufnagel L, Prevedel R, Kreshuk A.
Nat Methods. 2021 May;18(5):557-563. doi: 10.1038\/s41592-021-01136-0. Epub 2021 May 7. PMID: 33963344<\/p>\n\n\n\n

NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes.
<\/a>Becker JP, Helm D, Rettel M, Stein F, Hernandez-Sanchez A, Urban K, Gebert J, Kloor M, Neu-Yilik G, von Knebel Doeberitz M, Hentze MW, Kulozik AE.
iScience. 2021 Apr 1;24(4):102389. doi: 10.1016\/j.isci.2021.102389. eCollection 2021 Apr 23. PMID: 33981976<\/p>\n\n\n\n

Hotspot DNMT3A<\/em> mutations in Clonal Hematopoiesis and Acute Myeloid Leukemia sensitize cells to Azacytidine via viral mimicry response<\/a>.
Scheller M, Ludwig A K, G\u00f6llnerS, RohdeC, Kr\u00e4merS, St\u00e4bleS, Janssen M, M\u00fcller J-A, HeL, B\u00e4umerN, ArnoldC, Ger\u00df J, Sch\u00f6nung M, ThiedeC, NiederwieserC, NiederwieserD, ServeH, BerdelW E, ThiemU, HemmerlingI, LeuschnerF, PlassC, Schlesner M, ZauggJ, MilsomM, TrumppA, PabstC, LipkaD B, M\u00fcller-TidowC. 
Nature Cancer <\/em>volume <\/strong>2, pages 527\u2013544 (2021).<\/p>\n\n\n\n

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut.<\/a>
Triana S, Metz-Zumaran C, Ramirez C, Kee C, Doldan P, Shahraz M, Schraivogel D, Gschwind AR, Sharma AK, Steinmetz LM, Herrmann C, Alexandrov T, Boulant S, Stanifer ML.
Mol Syst Biol. 2021 Apr;17(4):e10232. doi: 10.15252\/msb.202110232. PMID: 33904651<\/p>\n\n\n\n

Microbiome meta-analysis and cross-disease comparison enabled by the SIAMCAT machine learning toolbox.<\/a>
Wirbel J, Zych K, Essex M, Karcher N, Kartal E, Salazar G, Bork P, Sunagawa S, Zeller G.
Genome Biol. 2021 Mar 30;22(1):93. doi: 10.1186\/s13059-021-02306-1. PMID: 33785070 Free PMC article.<\/p>\n\n\n\n

Vasculo-toxic and pro-inflammatory action of unbound haemoglobin, haem and iron in transfusion-dependent patients with haemolytic anaemias.<\/a>
Vinchi F, Sparla R, Passos ST, Sharma R, Vance SZ, Zreid HS, Juaidi H, Manwani D, Yazdanbakhsh K, Nandi V, Silva AMN, Agarvas AR, Fibach E, Belcher JD, Vercellotti GM, Ghoti H, Muckenthaler MU.
Br J Haematol. 2021 Mar 15. doi: 10.1111\/bjh.17361. Online ahead of print. PMID: 33723861<\/p>\n\n\n\n

The role of cellular iron deficiency in controlling iron export.<\/a>
Link C, Knopf JD, Marques O, Lemberg MK, Muckenthaler MU.
Biochim Biophys Acta Gen Subj. 2021 Mar;1865(3):129829. doi: 10.1016\/j.bbagen.2020.129829. Epub 2020 Dec 16. PMID: 33340587<\/p>\n\n\n\n

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
<\/a>Velten L, Story BA, Hern\u00e1ndez-Malmierca P, Raffel S, Leonce DR, Milbank J, Paulsen M, Demir A, Szu-Tu C, Fr\u00f6mel R, Lutz C, Nowak D, Jann JC, Pabst C, Boch T, Hofmann WK, M\u00fcller-Tidow C, Trumpp A, Haas S, Steinmetz LM.
Nat Commun. 2021 Mar 1;12(1):1366. doi: 10.1038\/s41467-021-21650-1. PMID: 33649320<\/p>\n\n\n\n

Global analysis of RNA-binding protein dynamics by comparative and enhanced RNA interactome capture.<\/a>
Perez-Perri JI, Noerenberg M, Kamel W, Lenz CE, Mohammed S, Hentze MW, Castello A.
Nat Protoc. 2021 Jan;16(1):27-60. doi: 10.1038\/s41596-020-00404-1. Epub 2020 Nov 18. PMID: 33208978<\/p>\n\n\n\n

Iron deficiency.<\/a>
Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW.
Lancet. 2021 Jan 16;397(10270):233-248. doi: 10.1016\/S0140-6736(20)32594-0. Epub 2020 Dec 4. PMID: 33285139 Review.<\/p>\n\n\n\n

Mild Attenuation of the Pulmonary Inflammatory Response in a Mouse Model of Hereditary Hemochromatosis Type 4.<\/a>
Marques O, Neves J, Horvat NK, Altamura S, Muckenthaler MU.
Front Physiol. 2021 Jan 13;11:589351. doi: 10.3389\/fphys.2020.589351. eCollection 2020. PMID: 33519502<\/p>\n\n\n\n

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis.<\/a>
Suwala AK, Stichel D, Schrimpf D, Kloor M, Wefers AK, Reinhardt A, Maas SLN, Kratz CP, Schweizer L, Hasselblatt M, Snuderl M, Abedalthagafi MSJ, Abdullaev Z, Monoranu CM, Bergmann M, Pekrun A, Freyschlag C, Aronica E, Kramm CM, Hinz F, Sievers P, Korshunov A, Kool M, Pfister SM, Sturm D, Jones DTW, Wick W, Unterberg A, Hartmann C, Dodgshun A, Tabori U, Wesseling P, Sahm F, von Deimling A, Reuss DE.
Acta Neuropathol. 2021 Jan;141(1):85-100. doi: 10.1007\/s00401-020-02243-6. Epub 2020 Nov 20. PMID: 33216206<\/p>\n\n\n\n

Decoding myofibroblast origins in human kidney fibrosis.<\/a>
Kuppe C, Ibrahim MM, Kranz J, Zhang X, Ziegler S, Perales-Pat\u00f3n J, Jansen J, Reimer KC, Smith JR, Dobie R, Wilson-Kanamori JR, Halder M, Xu Y, Kabgani N, Kaesler N, Klaus M, Gernhold L, Puelles VG, Huber TB, Boor P, Menzel S, Hoogenboezem RM, Bindels EMJ, Steffens J, Floege J, Schneider RK, Saez-Rodriguez J, Henderson NC, Kramann R.
Nature. 2021 Jan;589(7841):281-286. doi: 10.1038\/s41586-020-2941-1. Epub 2020 Nov 11. PMID: 33176333<\/p>\n\n\n\n

The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets.<\/a>
Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, Doncheva NT, Legeay M, Fang T, Bork P, Jensen LJ, von Mering C.
Nucleic Acids Res. 2021 Jan 8;49(D1):D605-D612. doi: 10.1093\/nar\/gkaa1074. PMID: 33237311 Free PMC article.<\/p>\n\n\n\n

OGEE v3: Online GEne Essentiality database with increased coverage of organisms and human cell lines.<\/a>
Gurumayum S, Jiang P, Hao X, Campos TL, Young ND, Korhonen PK, Gasser RB, Bork P, Zhao XM, He LJ, Chen WH.
Nucleic Acids Res. 2021 Jan 8;49(D1):D998-D1003. doi: 10.1093\/nar\/gkaa884. PMID: 33084874 Free PMC article.<\/p>\n\n\n\n

The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.<\/a>
Roider T, Wang X, H\u00fcttl K, M\u00fcller-Tidow C, Klapper W, Rosenwald A, Stewart JP, de Castro DG, Dreger P, Hermine O, Kluin-Nelemans HC, Grabe N, Dreyling M, Pott C, Ott G, Hoster E, Dietrich S.
Int J Cancer. 2021 Jan 1;148(1):150-160. doi: 10.1002\/ijc.33202. Epub 2020 Aug 15. PMID: 32638373<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2020<\/summary>\n
\n\n

Author Correction: Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.<\/a>
Molinaro A, Bel Lassen P, Henricsson M, Wu H, Adriouch S, Belda E, Chakaroun R, Nielsen T, Bergh PO, Rouault C, Andr\u00e9 S, Marquet F, Andreelli F, Salem JE, Assmann K, Bastard JP, Forslund S, Le Chatelier E, Falony G, Pons N, Prifti E, Quinquis B, Roume H, Vieira-Silva S, Hansen TH, Pedersen HK, Lewinter C, S\u00f8nderskov NB; MetaCardis Consortium, K\u00f8ber L, Vestergaard H, Hansen T, Zucker JD, Galan P, Dumas ME, Raes J, Oppert JM, Letunic I, Nielsen J, Bork P, Ehrlich SD, Stumvoll M, Pedersen O, Aron-Wisnewsky J, Cl\u00e9ment K, B\u00e4ckhed F.
Nat Commun. 2020 Dec 21;11(1):6448. doi: 10.1038\/s41467-020-20412-9. PMID: 33349634 Free PMC article.<\/p>\n\n\n\n

IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease.<\/a>
Hagner M, Albrecht M, Guerra M, Braubach P, Halle O, Zhou-Suckow Z, Butz S, Jonigk D, Hansen G, Schultz C, Dittrich AM, Mall MA.
Eur Respir J. 2020 Dec 10:1900716. doi: 10.1183\/13993003.00716-2019. Online ahead of print.
PMID: 33303549<\/p>\n\n\n\n

Identification of MLH2\/hPMS1 dominant mutations that prevent DNA mismatch repair function.<\/a>
Reyes GX, Zhao B, Schmidt TT, Gries K, Kloor M, Hombauer H.
Commun Biol. 2020 Dec 10;3(1):751. doi: 10.1038\/s42003-020-01481-4.
PMID: 33303966<\/p>\n\n\n\n

Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies.<\/a>
Cortese M, Lee JY, Cerikan B, Neufeldt CJ, Oorschot VMJ, K\u00f6hrer S, Hennies J, Schieber NL, Ronchi P, Mizzon G, Romero-Brey I, Santarella-Mellwig R, Schorb M, Boermel M, Mocaer K, Beckwith MS, Templin RM, Gross V, Pape C, Tischer C, Frankish J, Horvat NK, Laketa V, Stanifer M, Boulant S, Ruggieri A, Chatel-Chaix L, Schwab Y, Bartenschlager R.
Cell Host Microbe. 2020 Dec 9;28(6):853-866.e5. doi: 10.1016\/j.chom.2020.11.003. Epub 2020 Nov 17. PMID: 33245857<\/p>\n\n\n\n

Severity-adjusted evaluation of newborn screening on the metabolic disease course in individuals with cytosolic urea cycle disorders.<\/a>
Posset R, K\u00f6lker S, Gleich F, Okun JG, Gropman AL, Nagamani SCS, Scharre S, Probst J, Walter ME, Hoffmann GF, Garbade SF, Zielonka M; Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD) consortia study group.
Mol Genet Metab. 2020 Dec;131(4):390-397. doi: 10.1016\/j.ymgme.2020.10.013. Epub 2020 Nov 7. PMID: 33288448<\/p>\n\n\n\n

Correction to: The majority of \u03b2-catenin mutations in colorectal cancer is homozygous.<\/a>
Arnold A, Tronser M, Sers C, Ahadova A, Endris V, Mamlouk S, Horst D, M\u00f6bs M, Bischoff P, Kloor M, Bl\u00e4ker H.
BMC Cancer. 2020 Nov 26;20(1):1151. doi: 10.1186\/s12885-020-07645-z. PMID: 33243186<\/p>\n\n\n\n

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia.<\/a>
Roels J, Th\u00e9noz M, Szarzy\u0144ska B, Landfors M, De Coninck S, Demoen L, Provez L, Kuchmiy A, Strubbe S, Reunes L, Pieters T, Matthijssens F, Van Loocke W, Erarslan-Uysal B, Richter-Pecha\u0144ska P, Declerck K, Lammens T, De Moerloose B, Deforce D, Van Nieuwerburgh F, Cheung LC, Kotecha RS, Mansour MR, Ghesqui\u00e8re B, Van Camp G, Berghe WV, Kowalczyk JR, Szczepa\u0144ski T, Dav\u00e9 UP, Kulozik AE, Goossens S, Curtis DJ, Taghon T, Dawidowska M, Degerman S, Van Vlierberghe P.
Blood Cancer Discov. 2020 Nov;1(3):274-289. doi: 10.1158\/2643-3230.BCD-20-0059. Epub 2020 Sep 23. PMID: 33179015<\/p>\n\n\n\n

HFE and ALK3 act in the same signaling pathway.<\/a>
Traeger L, Schnittker J, Dogan DY, Oguama D, Kuhlmann T, Muckenthaler MU, Krijt J, Urzica EI, Steinbicker AU.
Free Radic Biol Med. 2020 Nov 20;160:501-505. doi: 10.1016\/j.freeradbiomed.2020.08.023. Epub 2020 Aug 27. PMID: 32861780<\/p>\n\n\n\n

Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology.<\/a>
Molinaro A, Bel Lassen P, Henricsson M, Wu H, Adriouch S, Belda E, Chakaroun R, Nielsen T, Bergh PO, Rouault C, Andr\u00e9 S, Marquet F, Andreelli F, Salem JE, Assmann K, Bastard JP, Forslund S, Le Chatelier E, Falony G, Pons N, Prifti E, Quinquis B, Roume H, Vieira-Silva S, Hansen TH, Pedersen HK, Lewinter C, S\u00f8nderskov NB; MetaCardis Consortium, K\u00f8ber L, Vestergaard H, Hansen T, Zucker JD, Galan P, Dumas ME, Raes J, Oppert JM, Letunic I, Nielsen J, Bork P, Ehrlich SD, Stumvoll M, Pedersen O, Aron-Wisnewsky J, Cl\u00e9ment K, B\u00e4ckhed F.
Nat Commun. 2020 Nov 18;11(1):5881. doi: 10.1038\/s41467-020-19589-w. PMID: 33208748 Free PMC article. Clinical Trial.<\/p>\n\n\n\n

Protease FRET Reporters Targeting Neutrophil Extracellular Traps.<\/a>
Guerra M, Halls VS, Schatterny J, Hagner M, Mall MA, Schultz C.
J Am Chem Soc. 2020 Nov 13. doi: 10.1021\/jacs.0c08130. Online ahead of print. PMID: 33186023<\/p>\n\n\n\n

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia.<\/a>
Roels J, Th\u00e9noz M, Szarzy\u0144ska B, Landfors M, De Coninck S, Demoen L, Provez L, Kuchmiy A, Strubbe S, Reunes L, Pieters T, Matthijssens F, Van Loocke W, Erarslan-Uysal B, Richter-Pecha\u0144ska P, Declerck K, Lammens T, De Moerloose B, Deforce D, Van Nieuwerburgh F, Cheung LC, Kotecha RS, Mansour MR, Ghesqui\u00e8re B, Van Camp G, Berghe WV, Kowalczyk JR, Szczepa\u0144ski T, Dav\u00e9 UP, Kulozik AE, Goossens S, Curtis DJ, Taghon T, Dawidowska M, Degerman S, Van Vlierberghe P.
Blood Cancer Discov. 2020 Nov;1(3):274-289. doi: 10.1158\/2643-3230.BCD-20-0059. Epub 2020 Sep 23. PMID: 33179015<\/p>\n\n\n\n

The majority of \u03b2-catenin mutations in colorectal cancer is homozygous.<\/a>
Arnold A, Tronser M, Sers C, Ahadova A, Endris V, Mamlouk S, Horst D, M\u00f6bs M, Bischoff P, Kloor M, Bl\u00e4ker H.
BMC Cancer. 2020 Oct 28;20(1):1038. doi: 10.1186\/s12885-020-07537-2. PMID: 33115416<\/p>\n\n\n\n

Pharmacological inhibition of nonsense-mediated RNA decay augments HLA class I-mediated presentation of neoepitopes in MSI CRC<\/a>
Jonas P. Becker, Dominic Helm, Mandy Rettel, Frank Stein, Alejandro Hernandez-Sanchez, Katharina Urban, Johannes Gebert, Matthias Kloor, Gabriele Neu-Yilik, Magnus von Knebel Doeberitz, Matthias W. Hentze, Andreas E. Kulozik
bioRxiv:2020 Oct 13 doi: https:\/\/doi.org\/10.1101\/2020.10.13.319970<\/p>\n\n\n\n

The tissue proteome in the multi-omic landscape of kidney disease.<\/a>
Rinschen MM, Saez-Rodriguez J.
Nat Rev Nephrol. 2020 Oct 7. doi: 10.1038\/s41581-020-00348-5. Online ahead of print. PMID: 33028957 Review.<\/p>\n\n\n\n

Age-dependent performance of BRAF mutation testing in Lynch syndrome diagnostics.<\/a>
Bl\u00e4ker H, Haupt S, Morak M, Holinski-Feder E, Arnold A, Horst D, Sieber-Frank J, Seidler F, von Winterfeld M, Alwers E, Chang-Claude J, Brenner H, Roth W, Engel C, L\u00f6ffler M, M\u00f6slein G, Schackert HK, Weitz J, Perne C, Aretz S, H\u00fcneburg R, Schmiegel W, Vangala D, Rahner N, Steinke-Lange V, Heuveline V, von Knebel Doeberitz M, Ahadova A, Hoffmeister M, Kloor M; German Consortium for Familial Intestinal Cancer.
Int J Cancer. 2020 Nov 15;147(10):2801-2810. doi: 10.1002\/ijc.33273. Epub 2020 Sep 14. PMID: 32875553<\/p>\n\n\n\n

The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution.<\/a>
Ballhausen A, Przybilla MJ, Jendrusch M, Haupt S, Pfaffendorf E, Seidler F, Witt J, Hernandez Sanchez A, Urban K, Draxlbauer M, Krausert S, Ahadova A, Kalteis MS, Pfuderer PL, Heid D, Stichel D, Gebert J, Bonsack M, Schott S, Bl\u00e4ker H, Sepp\u00e4l\u00e4 T, Mecklin JP, Ten Broeke S, Nielsen M, Heuveline V, Krzykalla J, Benner A, Riemer AB, von Knebel Doeberitz M, Kloor M.
Nat Commun. 2020 Sep 21;11(1):4740. doi: 10.1038\/s41467-020-18514-5. PMID: 32958755<\/p>\n\n\n\n

Diversity within species: interpreting strains in microbiomes.<\/a>
Van Rossum T, Ferretti P, Maistrenko OM, Bork P.
Nat Rev Microbiol. 2020 Sep;18(9):491-506. doi: 10.1038\/s41579-020-0368-1. Epub 2020 Jun 4. PMID: 32499497 Free PMC article. Review.<\/p>\n\n\n\n

Chronic hyperammonemia causes a hypoglutamatergic and hyperGABAergic metabolic state associated with neurobehavioral abnormalities in zebrafish larvae.<\/a>
Probst J, K\u00f6lker S, Okun JG, Kumar A, Gursky E, Posset R, Hoffmann GF, Peravali R, Zielonka M.
Exp Neurol. 2020 Sep;331:113330. doi: 10.1016\/j.expneurol.2020.113330. Epub 2020 Apr 25. PMID: 32339612<\/p>\n\n\n\n

Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors.<\/a>
Erarslan-Uysal B, Kunz JB, Rausch T, Richter-Pecha\u0144ska P, van Belzen IA, Frismantas V, Bornhauser B, Ordo\u00f1ez-Rueada D, Paulsen M, Benes V, Stanulla M, Schrappe M, Cario G, Escherich G, Bakharevich K, Kirschner-Schwabe R, Eckert C, Loukanov T, Gorenflo M, Waszak SM, Bourquin JP, Muckenthaler MU, Korbel JO, Kulozik AE.
EMBO Mol Med. 2020 Sep 7;12(9):e12104. doi: 10.15252\/emmm.202012104. Epub 2020 Aug 5. PMID: 32755029<\/p>\n\n\n\n

A Frameshift Peptide Neoantigen-Based Vaccine for Mismatch Repair-Deficient Cancers: A Phase I\/IIa Clinical Trial.<\/a>
Kloor M, Reuschenbach M, Pauligk C, Karbach J, Rafiyan MR, Al-Batran SE, Tariverdian M, J\u00e4ger E, von Knebel Doeberitz M.
Clin Cancer Res. 2020 Sep 1;26(17):4503-4510. doi: 10.1158\/1078-0432.CCR-19-3517. Epub 2020 Jun 15. PMID: 32540851<\/p>\n\n\n\n

Prexasertib (LY2606368) reduces clonogenic survival by inducing apoptosis in primary patient-derived osteosarcoma cells and synergizes with cisplatin and talazoparib.<\/a>
Heidler CL, Roth EK, Thiemann M, Blattmann C, Perez RL, Huber PE, Kovac M, Amthor B, Neu-Yilik G, Kulozik AE.
Int J Cancer. 2020 Aug 15;147(4):1059-1070. doi: 10.1002\/ijc.32814. Epub 2019 Dec 19. PMID: 31782150<\/p>\n\n\n\n

Plant nutrient-acquisition strategies drive topsoil microbiome structure and function.<\/a>
Bahram M, Netherway T, Hildebrand F, Pritsch K, Drenkhan R, Loit K, Anslan S, Bork P, Tedersoo L.
New Phytol. 2020 Aug;227(4):1189-1199. doi: 10.1111\/nph.16598. Epub 2020 May 6. PMID: 32279325<\/p>\n\n\n\n

Miniaturized Drug Sensitivity and Resistance Test on Patient-Derived Cells Using Droplet-Microarray.<\/a>
Popova AA, Dietrich S, Huber W, Reischl M, Peravali R, Levkin PA.
SLAS Technol. 2020 Aug 13:2472630320934432. doi: 10.1177\/2472630320934432. Online ahead of print. PMID: 32791934<\/p>\n\n\n\n

Chromatin accessibility landscape of pediatric T-lymphoblastic leukemia and human T-cell precursors.<\/a>
Erarslan-Uysal B, Kunz JB, Rausch T, Richter-Pecha\u0144ska P, van Belzen IA, Frismantas V, Bornhauser B, Ordo\u00f1ez-Rueada D, Paulsen M, Benes V, Stanulla M, Schrappe M, Cario G, Escherich G, Bakharevich K, Kirschner-Schwabe R, Eckert C, Loukanov T, Gorenflo M, Waszak SM, Bourquin JP, Muckenthaler MU, Korbel JO, Kulozik AE.
EMBO Mol Med. 2020 Aug 5:e12104. doi: 10.15252\/emmm.202012104. Online ahead of print. PMID: 32755029<\/p>\n\n\n\n

Regulation of iron homeostasis: Lessons from mouse models.<\/a>
Altamura S, Marques O, Colucci S, Mertens C, Alikhanyan K, Muckenthaler MU.
Mol Aspects Med. 2020 Aug 10:100872. doi: 10.1016\/j.mam.2020.100872. Online ahead of print. PMID: 32792212<\/p>\n\n\n\n

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.<\/a>
Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU.
Eur Heart J. 2020 Jul 21;41(28):2681-2695. doi: 10.1093\/eurheartj\/ehz112. PMID: 30903157<\/p>\n\n\n\n

(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A.<\/a>
Michalak M, Katzenmaier EM, Roeckel N, Woerner SM, Fuchs V, Warnken U, Yuan YP, Bork P, Neu-Yilik G, Kulozik A, von Knebel Doeberitz M, Kloor M, Kopitz J, Gebert
J. Int J Mol Sci. 2020 Jul 23;21(15):5234. doi: 10.3390\/ijms21155234. PMID: 32718059<\/p>\n\n\n\n

Long-term effects of medical management on growth and weight in individuals with urea cycle disorders.<\/a>
Posset R, Garbade SF, Gleich F, Gropman AL, de Lonlay P, Hoffmann GF, Garcia-Cazorla A, Nagamani SCS, Baumgartner MR, Schulze A, Dobbelaere D, Yudkoff M, K\u00f6lker S, Zielonka M; Urea Cycle Disorders Consortium (UCDC); European registry and network for Intoxication type Metabolic Diseases (E-IMD).
Sci Rep. 2020 Jul 20;10(1):11948. doi: 10.1038\/s41598-020-67496-3. PMID: 32686765<\/p>\n\n\n\n

The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance.<\/a>
Ahadova A, Sepp\u00e4l\u00e4 TT, Engel C, Gallon R, Burn J, Holinski-Feder E, Steinke-Lange V, M\u00f6slein G, Nielsen M, Ten Broeke SW, Laghi L, Dominguez-Valentin M, Capella G, Macrae F, Scott R, H\u00fcneburg R, Nattermann J, Hoffmeister M, Brenner H, Bl\u00e4ker H, von Knebel Doeberitz M, Sampson JR, Vasen H, Mecklin JP, M\u00f8ller P, Kloor M.
Int J Cancer. 2020 Jul 19. doi: 10.1002\/ijc.33224. Online ahead of print. PMID: 32683684<\/p>\n\n\n\n

UPF1-Mediated RNA Decay-Danse Macabre in a Cloud.<\/a>
Lavysh D, Neu-Yilik G.
Biomolecules. 2020 Jul 4;10(7):999. doi: 10.3390\/biom10070999. PMID: 32635561<\/p>\n\n\n\n

The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.<\/a>
Roider T, Wang X, H\u00fcttl K, M\u00fcller-Tidow C, Klapper W, Rosenwald A, Stewart JP, Gonzalez de Castro D, Dreger P, Hermine O, Kluin-Nelemans HC, Grabe N, Dreyling M, Pott C, Ott G, Hoster E, Dietrich S.
Int J Cancer. 2020 Jul 7. doi: 10.1002\/ijc.33202. Online ahead of print. PMID: 32638373<\/p>\n\n\n\n

Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels.<\/a>
Roider T, Seufert J, Uvarovskii A, Frauhammer F, Bordas M, Abedpour N, Stolarczyk M, Mallm JP, Herbst SA, Bruch PM, Balke-Want H, Hundemer M, Rippe K, Goeppert B, Seiffert M, Brors B, Mechtersheimer G, Zenz T, Peifer M, Chapuy B, Schlesner M, M\u00fcller-Tidow C, Fr\u00f6hling S, Huber W, Anders S, Dietrich S.
Nat Cell Biol. 2020 Jul;22(7):896-906. doi: 10.1038\/s41556-020-0532-x. Epub 2020 Jun 15. PMID: 32541878<\/p>\n\n\n\n

A proof of concept phase I\/II pilot trial of LSD1 inhibition by tranylcypromine combined with ATRA in refractory\/relapsed AML patients not eligible for intensive therapy.<\/a>
Wass M, G\u00f6llner S, Besenbeck B, Schlenk RF, Mundmann P, G\u00f6thert JR, Noppeney R, Schliemann C, Mikesch JH, Lenz G, Dugas M, Wermke M, R\u00f6llig C, Bornh\u00e4user M, Serve H, Platzbecker U, Foerster KI, Burhenne J, Haefeli WE, M\u00fcller LP, Binder M, Pabst C, M\u00fcller-Tidow C; Study Alliance Leukemia (SAL).
Leukemia. 2020 Jun 19:1-11. doi: 10.1038\/s41375-020-0892-z. Online ahead of print. PMID: 32561840<\/p>\n\n\n\n

Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acute myeloid leukemia cell proliferation.<\/a>
Pauli C, Liu Y, Rohde C, Cui C, Fijalkowska D, Gerloff D, Walter C, Krijgsveld J, Dugas M, Edemir B, Pabst C, M\u00fcller LP, Zhou F, M\u00fcller-Tidow C.
Blood. 2020 Jun 4;135(23):2059-2070. doi: 10.1182\/blood.2019004121. PMID: 32097467<\/p>\n\n\n\n

Implications of Hereditary Origin on the Immune Phenotype of Mismatch Repair-Deficient Cancers: Systematic Literature Review.<\/a>
Bohaumilitzky L, von Knebel Doeberitz M, Kloor M, Ahadova A.
J Clin Med. 2020 Jun 4;9(6):1741. doi: 10.3390\/jcm9061741. PMID: 32512823<\/p>\n\n\n\n

BRAF inhibitor treatment in classic hairy cell leukemia: a long-term follow-up study of patients treated outside clinical trials.<\/a>
Liebers N, Roider T, Bohn JP, Haberbosch I, Pircher A, Ferstl B, Ebn\u00f6ther M, Wendtner CM, Dearden C, Follows GA, Ho AD, M\u00fcller-Tidow C, Dreger P, Troussard X, Zenz T, Dietrich S.
Leukemia 2020 May;34(5):1454-1457. doi: 10.1038\/s41375-019-0646-y. Epub 2019 Nov 18. PMID: 31740808<\/p>\n\n\n\n

From genotype to phenotype: Early prediction of disease severity in argininosuccinic aciduria.<\/a>
Zielonka M, Garbade SF, Gleich F, Okun JG, Nagamani SCS, Gropman AL, Hoffmann GF, K\u00f6lker S, Posset R; Urea Cycle Disorders Consortium (UCDC) and the European registry and network for Intoxication type Metabolic Diseases (E-IMD) Consortia Study Group.
Hum Mutat. 2020 May;41(5):946-960. doi: 10.1002\/humu.23983. Epub 2020 Jan 30. PMID: 31943503<\/p>\n\n\n\n

Glycogen accumulation, central carbon metabolism, and aging of hematopoietic stem and progenitor cells<\/a>
Laura poisa\u2011Beiro, Judith Thoma, Jonathan Landry, Sven Sauer, Akihisa Yamamoto, Volker Eckstein, Natalie Romanov, Simon Raffel, Georg F. Hoffmann, Peer Bork, Vladimir Benes, Anne\u2011claude Gavin, Motomu Tanaka & Anthony D. Ho
Scientific Reports | (2020) 10:11597 | https:\/\/doi.org\/10.1038\/s41598-020-68396-2www.nature.com\/scientificreports<\/p>\n\n\n\n

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis.<\/a>
Vieira-Silva S, Falony G, Belda E, Nielsen T, Aron-Wisnewsky J, Chakaroun R, Forslund SK, Assmann K, Valles-Colomer M, Nguyen TTD, Proost S, Prifti E, Tremaroli V, Pons N, Le Chatelier E, Andreelli F, Bastard JP, Coelho LP, Galleron N, Hansen TH, Hulot JS, Lewinter C, Pedersen HK, Quinquis B, Rouault C, Roume H, Salem JE, S\u00f8ndertoft NB, Touch S; MetaCardis Consortium, Dumas ME, Ehrlich SD, Galan P, G\u00f8tze JP, Hansen T, Holst JJ, K\u00f8ber L, Letunic I, Nielsen J, Oppert JM, Stumvoll M, Vestergaard H, Zucker JD, Bork P, Pedersen O, B\u00e4ckhed F, Cl\u00e9ment K, Raes J.
Nature. 2020 May;581(7808):310-315. doi: 10.1038\/s41586-020-2269-x. Epub 2020 May 6. PMID: 32433607<\/p>\n\n\n\n

Plasticity of nuclear and cytoplasmic stress responses of RNA-binding proteins.<\/a>
Backlund M, Stein F, Rettel M, Schwarzl T, Perez-Perri JI, Brosig A, Zhou Y, Neu-Yilik G, Hentze MW, Kulozik AE. Nucleic Acids Res. 2020 May 21;48(9):4725-4740. doi: 10.1093\/nar\/gkaa256. PMID: 32313943<\/p>\n\n\n\n

Disentangling the impact of environmental and phylogenetic constraints on prokaryotic within-species diversity.<\/a>
Maistrenko OM, Mende DR, Luetge M, Hildebrand F, Schmidt TSB, Li SS, Rodrigues JFM, von Mering C, Pedro Coelho L, Huerta-Cepas J, Sunagawa S, Bork P.
ISME J. 2020 May;14(5):1247-1259. doi: 10.1038\/s41396-020-0600-z. Epub 2020 Feb 11. PMID: 32047279 Free PMC article.<\/p>\n\n\n\n

New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.<\/a>
Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA.
Eur Respir J. 2020 Apr 30;55(4):1902355. doi: 10.1183\/13993003.02355-2019. Print 2020 Apr.
PMID: 32139467<\/p>\n\n\n\n

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.<\/a>
Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, H\u00fcltner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, de Angelis MTH, Buske C, Silva ARD, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW.
Haematologica. 2020 Apr;105(4):937-950. doi: 10.3324\/haematol.2018.212977. Epub 2019 Jun 27. PMID: 31248967<\/p>\n\n\n\n

Tracy: basecalling, alignment, assembly and deconvolution of sanger chromatogram trace files.<\/a>
Rausch T, Fritz MH, Untergasser A, Benes V.
BMC Genomics. 2020 Mar 14;21(1):230. doi: 10.1186\/s12864-020-6635-8. PMID: 32171249<\/p>\n\n\n\n

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations. <\/a>
Trzaska C, Amand S, Bailly C, Leroy C, Marchand V, Duvernois-Berthet E, Saliou JM, Benhabiles H, Werkmeister E, Chassat T, Guilbert R, Hannebique D, Mouray A, Copin MC, Moreau PA, Adriaenssens E, Kulozik A, Westhof E, Tulasne D, Motorin Y, Rebuffat S, Lejeune F.
Nat Commun. 2020 Mar 20;11(1):1509. doi: 10.1038\/s41467-020-15140-z. PMID: 32198346<\/p>\n\n\n\n

Single-cell analysis of structural variations and complex rearrangements with tri-channel processing.<\/a>
Sanders AD, Meiers S, Ghareghani M, Porubsky D, Jeong H, van Vliet MACC, Rausch T, Richter-Pecha\u0144ska P, Kunz JB, Jenni S, Bolognini D, Longo GMC, Raeder B, Kinanen V, Zimmermann J, Benes V, Schrappe M, Mardin BR, Kulozik AE, Bornhauser B, Bourquin JP, Marschall T, Korbel JO. Nat Biotechnol. 2020 Mar;38(3):343-354. doi: 10.1038\/s41587-019-0366-x. PMID: 31873213<\/p>\n\n\n\n

Identification of metabolites from tandem mass spectra with a machine learning approach utilizing structural features.<\/a>
Li Y, Kuhn M, Gavin AC, Bork P.
Bioinformatics. 2020 Feb 15;36(4):1213-1218. doi: 10.1093\/bioinformatics\/btz736. PMID: 31605112<\/p>\n\n\n\n

proGenomes2: an improved database for accurate and consistent habitat, taxonomic and functional annotations of prokaryotic genomes.<\/a>
Mende DR, Letunic I, Maistrenko OM, Schmidt TSB, Milanese A, Paoli L, Hern\u00e1ndez-Plaza A, Orakov AN, Forslund SK, Sunagawa S, Zeller G, Huerta-Cepas J, Coelho LP, Bork P.
Nucleic Acids Res. 2020 Jan 8;48(D1):D621-D625. doi: 10.1093\/nar\/gkz1002. PMID: 31647096 Free PMC article.<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2019<\/summary>\n
\n\n

The authors reply.<\/a>
Saez-Rodriguez J, Rinschen MM, Floege J, Kramann R.
Kidney Int. 2019 Dec;96(6):1422-1423. doi: 10.1016\/j.kint.2019.09.011.
PMID: 31759488 No abstract available.<\/p>\n\n\n\n

Metabolic rewiring of the hypertensive kidney.<\/a>
Rinschen MM, Palygin O, Guijas C, Palermo A, Palacio-Escat N, Domingo-Almenara X, Montenegro-Burke R, Saez-Rodriguez J, Staruschenko A, Siuzdak G.
Sci Signal. 2019 Dec 10;12(611):eaax9760. doi: 10.1126\/scisignal.aax9760. PMID: 31822592<\/p>\n\n\n\n

Dissecting intratumor heterogeneity of nodal b cell lymphomas on the transcriptional, genetic, and drug response level.<\/a>
Tobias Roider, Julian Seufert, Alexey Uvarovskii, Felix Frauhammer, Marie Bordas, Nima Abedpour, Marta Stolarczyk, Jan-Philipp Mallm, Sophie Rabe, Peter-Martin Bruch, Hyatt Balke-Want, Michael Hundemer, Karsten Rippe, Benjamin Goeppert, Martina Seiffert, Benedikt Brors, Gunhild Mechtersheimer, Thorsten Zenz, Martin Peifer, Bj\u00f6rn Chapuy, Matthias Schlesner, Carsten M\u00fcller-Tidow, Stefan Fr\u00f6hling, Wolfgang Huber, Simon Anders, and Sascha Dietrich.
bioR\u03c7iv<\/em>, Dec 2019<\/p>\n\n\n\n

Karyopherin \u03b12-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer.<\/a>
Drucker E, Holzer K, Pusch S, Winkler J, Calvisi DF, Eiteneuer E, Herpel E, Goeppert B, Roessler S, Ori A, Schirmacher P, Breuhahn K, Singer S.
Cell Commun Signal. 2019 Nov 29;17(1):159. doi: 10.1186\/s12964-019-0456-x. PMID:31783876<\/p>\n\n\n\n

Iron-Related Parameters are Altered Between C57BL\/6N and C57BL\/6J Mus Musculus<\/em> Wild-Type Substrains.<\/a>
Marques O, Neves J, Horvat NK, Colucci S, Guida C, Muckenthaler MU.
Hemasphere. 2019 Oct 22;3(6):e304. doi: 10.1097\/HS9.0000000000000304. eCollection 2019 Dec. PMID: 31976478<\/p>\n\n\n\n

SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1.<\/a>
Altamura S, Schaeper U, Dames S, L\u00f6ffler K, Eisermann M, Frauendorf C, M\u00fcdder K, Neves J, Muckenthaler MU.
Hemasphere. 2019 Oct 1;3(6):e301. doi: 10.1097\/HS9.0000000000000301. eCollection 2019 Dec. PMID: 31976476<\/p>\n\n\n\n

Early prediction of phenotypic severity in Citrullinemia Type 1.<\/a>
Zielonka M, K\u00f6lker S, Gleich F, St\u00fctzenberger N, Nagamani SCS, Gropman AL, Hoffmann GF, Garbade SF, Posset R; Urea Cycle Disorders Consortium (UCDC) and the European Registry and Network for Intoxication type Metabolic Diseases (E-IMD) Consortia Study Group.
Ann Clin Transl Neurol. 2019 Sep;6(9):1858-1871. doi: 10.1002\/acn3.50886. Epub 2019 Aug 30. PMID: 31469252<\/p>\n\n\n\n

Ultra-orphan lysosomal storage diseases: A cross-sectional quantitative analysis of the natural history of alpha-mannosidosis.<\/a>
Zielonka M, Garbade SF, K\u00f6lker S, Hoffmann GF, Ries M.
J Inherit Metab Dis. 2019 Sep;42(5):975-983. doi: 10.1002\/jimd.12138. Epub 2019 Jul 24.PMID:31222755<\/p>\n\n\n\n

Early prediction of phenotypic severity in Citrullinemia Type 1.<\/a>
Zielonka M, K\u00f6lker S, Gleich F, St\u00fctzenberger N, Nagamani SCS, Gropman AL, Hoffmann GF, Garbade SF, Posset R; Urea Cycle Disorders Consortium (UCDC) and the European Registry and Network for Intoxication type Metabolic Diseases (E-IMD) Consortia Study Group.
Ann Clin Transl Neurol. 2019 Aug 30. doi: 10.1002\/acn3.50886. [Epub ahead of print]PMID:31469252<\/p>\n\n\n\n

High endothelial venules are associated with microsatellite instability, hereditary background and immune evasion in colorectal cancer.<\/a>
Pfuderer PL, Ballhausen A, Seidler F, Stark HJ, Grabe N, Frayling IM, Ager A, von Knebel Doeberitz M, Kloor M, Ahadova A.
Br J Cancer. 2019 Aug;121(5):395-404. doi: 10.1038\/s41416-019-0514-6. Epub 2019 Jul 30. PMID:31358939<\/p>\n\n\n\n

Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma<\/a>.
Thielmann CM, Costa da Silva M, Muley T, Meister M, Herpel E, Muckenthaler MU.
Sci Rep. 2019 Aug 5;9(1):11326. doi: 10.1038\/s41598-019-47833-x. PMID:31383898<\/p>\n\n\n\n

The increase in hemoglobin concentration with altitude varies among human populations<\/a>.
Gassmann M, Mairb\u00e4url H, Livshits L, Seide S, Hackbusch M, Malczyk M, Kraut S, Gassmann NN, Weissmann N, Muckenthaler MU.
Ann N Y Acad Sci. 2019 Aug;1450(1):204-220. doi: 10.1111\/nyas.14136. Epub 2019 Jun 30. PMID: 31257609<\/p>\n\n\n\n

Cardiac K2P13.1 (THIK-1) two-pore-domain K+ channels: Pharmacological regulation and remodeling in atrial fibrillation.<\/a>
Staudacher I, Seehausen S, Illg C, Lugenbiel P, Schweizer PA, Katus HA, Thomas D.
Prog Biophys Mol Biol. 2019 Jul;144:128-138. doi: 10.1016\/j.pbiomolbio.2018.06.009. Epub 2018 Jul 6.PMID:31182191<\/p>\n\n\n\n

Impact of Diagnosis and Therapy on Cognitive Function in Urea Cycle Disorders.<\/a>
Posset R, Gropman AL, Nagamani SCS, Burrage LC, Bedoyan JK, Wong D, Berry GT, Baumgartner MR, Yudkoff M, Zielonka M, Hoffmann GF, Burgard P, Schulze A, McCandless SE, Garcia-Cazorla A, Seminara J, Garbade SF, K\u00f6lker S; Urea Cycle Disorders Consortium and the European Registry and Network for Intoxication Type Metabolic Diseases Consortia Study Group.
Ann Neurol. 2019 Jul;86(1):116-128. doi: 10.1002\/ana.25492. Epub 2019 May 13.PMID:31018246<\/p>\n\n\n\n

Effects of Weight-Loss Interventions on Short-Chain Fatty Acid Concentrations in Blood and Feces of Adults: A Systematic Review.<\/a>
Sowah SA, Riedl L, Damms-Machado A, Johnson TS, Sch\u00fcbel R, Graf M, Kartal E, Zeller G, Schwingshackl L, Stangl GI, Kaaks R, K\u00fchn T.
Adv Nutr. 2019 Jul 1;10(4):673-684. doi: 10.1093\/advances\/nmy125. PMID:31075175<\/p>\n\n\n\n

Towards standardisation of naming novel prokaryotic taxa in the age of high-throughput microbiology.<\/a>
Hildebrand F, Pallen MJ, Bork P.
Gut. 2019 Jun 15. pii: gutjnl-2019-319045. doi: 10.1136\/gutjnl-2019-319045. [Epub ahead of print] No abstract available. PMID:31203204<\/p>\n\n\n\n

NG-meta-profiler: fast processing of metagenomes using NGLess, a domain-specific language.<\/a>
Coelho LP, Alves R, Monteiro P, Huerta-Cepas J, Freitas AT, Bork P.
Microbiome. 2019 Jun 3;7(1):84. doi: 10.1186\/s40168-019-0684-8. PMID:31159881<\/p>\n\n\n\n

Big science and big data in nephrology.<\/a>
Saez-Rodriguez J, Rinschen MM, Floege J, Kramann R.
Kidney Int. 2019 Jun;95(6):1326-1337. doi: 10.1016\/j.kint.2018.11.048. Epub 2019 Mar 5. Review. PMID:30982672<\/p>\n\n\n\n

Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.<\/a>
Gossmann TI, Shanmugasundram A, B\u00f6rno S, Duvaux L, Lemaire C, Kuhl H, Klages S, Roberts LD, Schade S, Gostner JM, Hildebrand F, Vowinckel J, Bichet C, M\u00fclleder M, Calvani E, Zelezniak A, Griffin JL, Bork P, Allaine D, Cohas A, Welch JJ, Timmermann B, Ralser M.
Curr Biol. 2019 May 20;29(10):1712-1720.e7. doi: 10.1016\/j.cub.2019.04.020. Epub 2019 May 9. PMID:31080084<\/p>\n\n\n\n

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.<\/a>
Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F, Zolfo M, Beghini F, Manara S, Karcher N, Pozzi C, Gandini S, Serrano D, Tarallo S, Francavilla A, Gallo G, Trompetto M, Ferrero G, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Wirbel J, Schrotz-King P, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G, Cordero F, Dias-Neto E, Setubal JC, Tett A, Pardini B, Rescigno M, Waldron L, Naccarati A, Segata N.
Nat Med. 2019 Apr;25(4):667-678. doi: 10.1038\/s41591-019-0405-7. Epub 2019 Apr 1.<\/p>\n\n\n\n

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer.<\/a>
Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Nim\u00e9us E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G.
Nat Med. 2019 Apr;25(4):679-689. doi: 10.1038\/s41591-019-0406-6. Epub 2019 Apr 1.PMID:30936547<\/p>\n\n\n\n

Instantaneous isotropic volumetric imaging of fast biological processes.<\/a>
Wagner N, Norlin N, Gierten J, de Medeiros G, Bal\u00e1zs B, Wittbrodt J, Hufnagel L, Prevedel R.
Nat Methods. 2019 Apr 29. doi: 10.1038\/s41592-019-0393-z. [Epub ahead of print] PMID:31036959<\/p>\n\n\n\n

PTEN abnormalities predict poor outcome in children with T-cell acute lymphoblastic leukemia treated according to ALL IC-BFM protocols.<\/a>
Szarzy\u0144ska-Zawadzka B, Kunz JB, S\u0119dek \u0141, Kosmalska M, Zdon K, Biecek P, Bandapalli OR, Kraszewska-Hamilton M, Jaksik R, Drobna M, Kowalczyk JR, Szczepa\u0144ski T, Van Vlierberghe P, Kulozik AE, Witt M, Dawidowska M.
Am J Hematol. 2019 Apr;94(4):E93-E96. doi: 10.1002\/ajh.25396. Epub 2019 Jan 24. No abstract available. PMID: 30614545<\/p>\n\n\n\n

Elastase Exocytosis by Airway Neutrophils Is Associated with Early Lung Damage in Children with Cystic Fibrosis.<\/a>
Margaroli C, Garratt LW, Horati H, Dittrich AS, Rosenow T, Montgomery ST, Frey DL, Brown MR, Schultz C, Guglani L, Kicic A, Peng L, Scholte BJ, Mall MA, Janssens HM, Stick SM, Tirouvanziam R.
Am J Respir Crit Care Med. 2019 Apr 1;199(7):873-881. doi: 10.1164\/rccm.201803-0442OC. PMID:30281324<\/p>\n\n\n\n

Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation.<\/a>
Zielonka M, Probst J, Carl M, Hoffmann GF, K\u00f6lker S, Okun JG.
Exp Neurol. 2019 Apr;314:91-99. doi: 10.1016\/j.expneurol.2019.01.008. Epub 2019 Jan 14.PMID:30653968<\/p>\n\n\n\n

Clinical characteristics of 248 patients with Krabbe disease: quantitative natural history modeling based on published cases.<\/a>
Komatsuzaki S, Zielonka M, Mountford WK, K\u00f6lker S, Hoffmann GF, Garbade SF, Ries M.
Genet Med. 2019 Mar 22. doi: 10.1038\/s41436-019-0480-7. [Epub ahead of print]PMID:30899093<\/p>\n\n\n\n

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry.<\/a>
Guerra M, Frey D, Hagner M, Dittrich S, Paulsen M, Mall MA, Schultz C.
ACS Cent Sci. 2019 Mar 27;5(3):539-548. doi: 10.1021\/acscentsci.8b00933. Epub 2019 Feb 19. PMID:30937381<\/p>\n\n\n\n

Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction.<\/a>
Vinchi F, Porto G, Simmelbauer A, Altamura S, Passos ST, Garbowski M, Silva AMN, Spaich S, Seide SE, Sparla R, Hentze MW, Muckenthaler MU.
Eur Heart J. 2019 Mar 20. pii: ehz112. doi: 10.1093\/eurheartj\/ehz112. [Epub ahead of print] PMID:30903157<\/p>\n\n\n\n

Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice.<\/a>
Nocchi L, Roy N, D’Attilia M, Dhandapani R, Maffei M, Traista A, Castaldi L, Perlas E, Chadick CH, Heppenstall PA.
Nat Biomed Eng. 2019 Feb;3(2):114-125. doi: 10.1038\/s41551-018-0328-5. Epub 2018 Dec 17. PMID:30944432<\/p>\n\n\n\n

Microbial abundance, activity and population genomic profiling with mOTUs2.<\/a>
Milanese A, Mende DR, Paoli L, Salazar G, Ruscheweyh HJ, Cuenca M, Hingamp P, Alves R, Costea PI, Coelho LP, Schmidt TSB, Almeida A, Mitchell AL, Finn RD, Huerta-Cepas J, Bork P, Zeller G, Sunagawa S.
Nat Commun. 2019 Mar 4;10(1):1014. doi: 10.1038\/s41467-019-08844-4. PMID:30833550<\/p>\n\n\n\n

Extensive transmission of microbes along the gastrointestinal tract.<\/a>
Schmidt TS, Hayward MR, Coelho LP, Li SS, Costea PI, Voigt AY, Wirbel J, Maistrenko OM, Alves RJ, Bergsten E, de Beaufort C, Sobhani I, Heintz-Buschart A, Sunagawa S, Zeller G, Wilmes P, Bork P.
Elife. 2019 Feb 12;8. pii: e42693. doi: 10.7554\/eLife.42693. PMID:30747106<\/p>\n\n\n\n

miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma.<\/a>
Babu KR, Muckenthaler MU.
Sci Rep. 2019 Feb 6;9(1):1518. doi: 10.1038\/s41598-018-35947-7. PMID:30728365<\/p>\n\n\n\n

A cross-sectional quantitative analysis of the natural history of free sialic acid storage disease-an ultra-orphan multisystemic lysosomal storage disorder.<\/a>
Zielonka M, Garbade SF, K\u00f6lker S, Hoffmann GF, Ries M.
Genet Med. 2019 Feb;21(2):347-352. doi: 10.1038\/s41436-018-0051-3. Epub 2018 Jun 6.PMID:29875421<\/p>\n\n\n\n

A Chemogenetic Approach for the Optical Monitoring of Voltage in Neurons.<\/a>
Sundukova M, Prifti E, Bucci A, Kirillova K, Serrao J, Reymond L, Umebayashi M, Hovius R, Riezman H, Johnsson K, Heppenstall PA.
Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2341-2344. doi: 10.1002\/anie.201812967. Epub 2019 Jan 25. PMID:30569539<\/p>\n\n\n\n

Iron Homeostasis in the Lungs-A Balance between Health and Disease.<\/a>
Neves J, Haider T, Gassmann M, Muckenthaler MU.
Pharmaceuticals (Basel). 2019 Jan 1;12(1). pii: E5. doi: 10.3390\/ph12010005. Review. PMID:30609678<\/p>\n\n\n\n

Automated high-throughput heart rate measurement in medaka and zebrafish embryos under physiological conditions<\/a>.
Gierten J, Pylatiuk C, Hammouda OT, Schock C, Stegmaier J, Wittbrodt J, Gehrig J, Loosli F. 
bioRxiv doi: 10.1101\/548594<\/p>\n\n\n\n

Cloning and characterization of zebrafish K2P13.1 (THIK-1) two-pore-domain K+ channels.<\/a>
Staudacher I, Seehausen S, Gierten J, Illg C, Schweizer PA, Katus HA, Thomas D.
J Mol Cell Cardiol. 2019 Jan;126:96-104. doi: 10.1016\/j.yjmcc.2018.11.013. Epub 2018 Nov 22. PMID:30472253<\/p>\n\n\n\n

Antibiotics-induced monodominance of a novel gut bacterial order.<\/a>
Hildebrand F, Moitinho-Silva L, Blasche S, Jahn MT, Gossmann TI, Heuerta-Cepas J, Hercog R, Luetge M, Bahram M, Pryszlak A, Alves RJ, Waszak SM, Zhu A, Ye L, Costea PI, Aalvink S, Belzer C, Forslund SK, Sunagawa S, Hentschel U, Merten C, Patil KR, Benes V, Bork P.
Gut. 2019 Jan 18. pii: gutjnl-2018-317715. doi: 10.1136\/gutjnl-2018-317715. [Epub ahead of print] PMID:30658995<\/p>\n\n\n\n

STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.<\/a>
Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, Jensen LJ, Mering CV.
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613. doi: 10.1093\/nar\/gky1131. PMID:30476243<\/p>\n\n\n\n

eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses.<\/a>
Huerta-Cepas J, Szklarczyk D, Heller D, Hern\u00e1ndez-Plaza A, Forslund SK, Cook H, Mende DR, Letunic I, Rattei T, Jensen LJ, von Mering C, Bork P.
Nucleic Acids Res. 2019 Jan 8;47(D1):D309-D314. doi: 10.1093\/nar\/gky1085. PMID:30418610<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2018<\/summary>\n
\n\n

Structure and architecture of immature and mature murine leukemia virus capsids.<\/a>
Qu K, Glass B, Dole\u017eal M, Schur FKM, Murciano B, Rein A, Rumlov\u00e1 M, Ruml T, Kr\u00e4usslich HG, Briggs JAG.
Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11751-E11760. doi: 10.1073\/pnas.1811580115. Epub 2018 Nov 26. PMID:30478053<\/p>\n\n\n\n

PDX models recapitulate the genetic and epigenetic landscape of pediatric T-cell leukemia.<\/a>
Richter-Pecha\u0144ska P, Kunz JB, Bornhauser B, von Knebel Doeberitz C, Rausch T, Erarslan-Uysal B, Assenov Y, Frismantas V, Marovca B, Waszak SM, Zimmermann M, Seemann J, Happich M, Stanulla M, Schrappe M, Cario G, Escherich G, Bakharevich K, Kirschner-Schwabe R, Eckert C, Muckenthaler MU, Korbel JO, Bourquin JP, Kulozik AE.
EMBO Mol Med. 2018 Dec;10(12). pii: e9443. doi: 10.15252\/emmm.201809443. PMID:30389682<\/p>\n\n\n\n

Transferrin receptor 2 is a potential novel therapeutic target for \u03b2-thalassemia: evidence from a murine model.<\/a>
Artuso I, Lidonnici MR, Altamura S, Mandelli G, Pettinato M, Muckenthaler MU, Silvestri L, Ferrari G, Camaschella C, Nai A.
Blood. 2018 Nov 22;132(21):2286-2297. doi: 10.1182\/blood-2018-05-852277. Epub 2018 Sep 12.PMID:30209118<\/p>\n\n\n\n

Cell metabolism regulates integrin mechanosensing via an SLC3A2-dependent sphingolipid biosynthesis pathway.<\/a>
Boulter E, Estrach S, Tissot FS, Hennrich ML, Tosello L, Cailleteau L, de la Ballina LR, Pisano S, Gavin AC, F\u00e9ral CC.
Nat Commun. 2018 Nov 19;9(1):4862. doi: 10.1038\/s41467-018-07268-w. PMID:30451822<\/p>\n\n\n\n

Instantaneous isotropic volumetric imaging of fast biological processes<\/a>
Nils Wagner, Nils Norlin, Jakob Gierten, Gustavo de Medeiros, B\u00e1lint Bal\u00e1zs, Joachim Wittbrodt, Lars Hufnagel, Robert Prevedel
bioRxiv doi: 10.1101\/459370<\/p>\n\n\n\n

Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture.<\/a>
Perez-Perri JI, Rogell B, Schwarzl T, Stein F, Zhou Y, Rettel M, Brosig A, Hentze MW.
Nat Commun. 2018 Oct 23;9(1):4408. doi: 10.1038\/s41467-018-06557-8. PMID:30352994<\/p>\n\n\n\n

Integrated analysis of the immunological and genetic status in and across cancer types: impact of mutational signatures beyond tumor mutational burden.<\/a>
Budczies J, Seidel A, Christopoulos P, Endris V, Kloor M, Gy\u0151rffy B, Seliger B, Schirmacher P, Stenzinger A, Denkert C.
Oncoimmunology. 2018 Oct 19;7(12):e1526613. doi: 10.1080\/2162402X.2018.1526613. eCollection 2018. PMID:30524909<\/p>\n\n\n\n

German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management.<\/a>
Thomas D, Christ T, Fabritz L, Goette A, Hammw\u00f6hner M, Heijman J, Kocksk\u00e4mper J, Linz D, Odening KE, Schweizer PA, Wakili R, Voigt N.
Clin Res Cardiol. 2018 Oct 10. doi: 10.1007\/s00392-018-1377-1. [Epub ahead of print] Review. PMID: 30306295<\/p>\n\n\n\n

High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation.<\/a>
Mattei S, Tan A, Glass B, M\u00fcller B, Kr\u00e4usslich HG, Briggs JAG.
Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9401-E9410. doi: 10.1073\/pnas.1811237115. Epub 2018 Sep 14. PMID:30217893<\/p>\n\n\n\n

Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline.<\/a>
Hennrich ML, Romanov N, Horn P, Jaeger S, Eckstein V, Steeples V, Ye F, Ding X, Poisa-Beiro L, Lai MC, Lang B, Boultwood J, Luft T, Zaugg JB, Pellagatti A, Bork P, Aloy P, Gavin AC, Ho AD.
Nat Commun. 2018 Oct 1;9(1):4004. doi: 10.1038\/s41467-018-06353-4. PMID:30275468<\/p>\n\n\n\n

Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase.<\/a>
Zielonka M, Breuer M, Okun JG, Carl M, Hoffmann GF, K\u00f6lker S.
PLoS One. 2018 Sep 10;13(9):e0203707. doi: 10.1371\/journal.pone.0203707. eCollection 2018. PMID:30199544<\/p>\n\n\n\n

ALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2.<\/a>
Traeger L, Gallitz I, Sekhri R, B\u00e4umer N, Kuhlmann T, Kemming C, Holtkamp M, M\u00fcller JC, Karst U, Canonne-Hergaux F, Muckenthaler MU, Bloch DB, Olschewski A, Bartnikas TB, Steinbicker AU.
Free Radic Biol Med. 2018 Sep 15;129:127-137. doi: 10.1016\/j.freeradbiomed.2018.09.021. [Epub ahead of print] PMID:30227271<\/p>\n\n\n\n

Dietary stearic acid regulates mitochondria in vivo in humans.<\/a>
Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA.
Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038\/s41467-018-05614-6.PMID:30087348<\/p>\n\n\n\n

Software tools for automated transmission electron microscopy<\/a>
Martin Schorb, Isabella Haberbosch, Wim Hagen, Yannick Schwab, David Mastronardedoi: bioRxiv 2018, https:\/\/doi.org\/10.1101\/389502<\/p>\n\n\n\n

Identification and functional characterization of zebrafish K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels.<\/a>
Staudacher I, Illg C, Gierten J, Seehausen S, Schweizer PA, Katus HA, Thomas D.
Eur J Pharmacol. 2018 Jul 15;831:94-102. doi: 10.1016\/j.ejphar.2018.05.007. Epub 2018 May 9. PMID: 29753045<\/p>\n\n\n\n

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels.<\/a>
Staudacher I, Illg C, Chai S, Deschenes I, Seehausen S, Gramlich D, M\u00fcller ME, Wieder T, Rahm AK, Mayer C, Schweizer PA, Katus HA, Thomas D.
Naunyn Schmiedebergs Arch Pharmacol. 2018 Jul 14. doi: 10.1007\/s00210-018-1535-z. [Epub ahead of print]
PMID:30008082<\/p>\n\n\n\n

Three molecular pathways model colorectal carcinogenesis in Lynch syndrome.<\/a> Ahadova A, Gallon R, Gebert J, Ballhausen A, Endris V, Kirchner M, Stenzinger A, Burn J, von Knebel Doeberitz M, Bl\u00e4ker H, Kloor M.
Int J Cancer. 2018 Jul 1;143(1):139-150. doi: 10.1002\/ijc.31300. Epub 2018 Feb 23.<\/p>\n\n\n\n

MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-\u03baB.<\/a> Cordas Dos Santos DM, Eilers J, Sosa Vizcaino A, Orlova E, Zimmermann M, Stanulla M, Schrappe M, B\u00f6rner K, Grimm D, Muckenthaler MU, Kulozik AE, Kunz JB.
BMC Cancer. 2018 Jun 18;18(1):663. doi: 10.1186\/s12885-018-4525-0. PMID: 29914415<\/p>\n\n\n\n

The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages.<\/a>
Lim D, Kim KS, Jeong JH, Marques O, Kim HJ, Song M, Lee TH, Kim JI, Choi HS, Min JJ, Bumann D, Muckenthaler MU, Choy HE.
Nat Commun. 2018 May 29;9(1):2091. doi: 10.1038\/s41467-018-04446-8. PMID: 29844422<\/p>\n\n\n\n

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons.<\/a>
Dhandapani R, Arokiaraj CM, Taberner FJ, Pacifico P, Raja S, Nocchi L, Portulano C, Franciosa F, Maffei M, Hussain AF, de Castro Reis F, Reymond L, Perlas E, Garcovich S, Barth S, Johnsson K, Lechner SG, Heppenstall PA.
Nat Commun. 2018 Apr 24;9(1):1640. doi: 10.1038\/s41467-018-04049-3. PMID:29691410<\/p>\n\n\n\n

Complex pattern of immune evasion in MSI colorectal cancer.<\/a>
Ozcan M, Janikovits J, von Knebel Doeberitz M, Kloor M.
Oncoimmunology. 2018 Mar 26;7(7):e1445453. doi: 10.1080\/2162402X.2018.1445453. eCollection 2018<\/p>\n\n\n\n

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.<\/a>
Dittrich AS, K\u00fchbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA.
Eur Respir J. 2018 Mar 15. pii: 1701910. doi: 10.1183\/13993003.01910-2017. [Epub ahead of print]PMID: 29545279<\/p>\n\n\n\n

Hepatic Smad7<\/em> overexpression causes severe iron overload in mice.<\/a>
Lai D, Teng F, Hammad S, Werle J, Maas T, Teufel A, Muckenthaler MU, Dooley S, Vuji\u0107 Spasi\u0107 M.
Blood. 2018 Feb 1;131(5):581-585. doi: 10.1182\/blood-2017-07-796797. Epub 2017 Dec 13. No
bstract available. PMID:29237592<\/p>\n\n\n\n

One time quantitative PCR detection of Pseudomonas aeruginosa to discriminate intermittent from chronic infection in cystic fibrosis.<\/a>
Boutin S, Weitnauer M, Hassel S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH.
J Cyst Fibros. 2018 Jan 11. pii: S1569-1993(18)30001-8. doi: 10.1016\/j.jcf.2017.12.007. [Epub ahead of print] PMID:29336943<\/p>\n\n\n\n

Protection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization<\/a>.
Heiss, K., Maier, M. I., Hoffmann, A., Frank, R., Bendszus, M., Mueller, A. K., Pfeil,
J. Scientific reports, 2018, 8(1), 3085.<\/p>\n\n\n\n

Drug-perturbation-based stratification of blood cancer.<\/a>
Dietrich S, Ole\u015b M, Lu J, Sellner L, Anders S, Velten B, Wu B, H\u00fcllein J, da Silva Liberio M, Walther T, Wagner L, Rabe S, Ghidelli-Disse S, Bantscheff M, Ole\u015b AK, S\u0142abicki M, Mock A, Oakes CC, Wang S, Oppermann S, Lukas M, Kim V, Sill M, Benner A, Jauch A, Sutton LA, Young E, Rosenquist R, Liu X, Jethwa A, Lee KS, Lewis J, Putzker K, Lutz C, Rossi D, Mokhir A, Oellerich T, Zirlik K, Herling M, Nguyen-Khac F, Plass C, Andersson E, Mustjoki S, von Kalle C, Ho AD, Hensel M, D\u00fcrig J, Ringshausen I, Zapatka M, Huber W, Zenz T.
J Clin Invest. 2018 Jan 2;128(1):427-445. doi: 10.1172\/JCI93801. Epub 2017 Dec 11.PMID:29227286<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2017<\/summary>\n
\n\n

Uncoupled iron homeostasis in type 2 diabetes mellitus.<\/a>
Altamura S, Kopf S, Schmidt J, M\u00fcdder K, da Silva AR, Nawroth P, Muckenthaler MU.
J Mol Med (Berl). 2017 Dec;95(12):1387-1398. doi: 10.1007\/s00109-017-1596-3. Epub 2017 Oct 3.PMID: 28971221<\/p>\n\n\n\n

Performance of the Alere i RSV assay for point-of-care detection of respiratory syncytial virus in children<\/a>.
Schnee SV, Pfeil J Ihling CM, Tabatabai J, Schnitzler P
BMC Infectious Diseases Dec 2017 17:767<\/p>\n\n\n\n

Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.<\/a>Bali KK, Kuner R.
Pain. 2017 Nov;158(11):2243-2258. doi: 10.1097\/j.pain.0000000000001032. PMID: 28837503<\/p>\n\n\n\n

High numbers of PDCD1 (PD-1)-positive T cells and B2M mutations in microsatellite-unstable colorectal cancer.<\/a>
Janikovits J, M\u00fcller M, Krzykalla J, K\u00f6rner S, Echterdiek F, Lahrmann B, Grabe N, Schneider M, Benner A, Doeberitz MVK, Kloor M. 
Oncoimmunology. 2017 Nov 6;7(2):e1390640. doi: 10.1080\/2162402X.2017.1390640. eCollection 2018. PMID:29308317<\/p>\n\n\n\n

Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages.<\/a>
Costa da Silva M, Breckwoldt MO, Vinchi F, Correia MP, Stojanovic A, Thielmann CM, Meister M, Muley T, Warth A, Platten M, Hentze MW, Cerwenka A, Muckenthaler MU. 
Front Immunol. 2017 Nov 8;8:1479. doi: 10.3389\/fimmu.2017.01479. eCollection 2017. PMID: 29167669<\/p>\n\n\n\n

A cross-sectional quantitative analysis of the natural history of Farber disease: an ultra-orphan condition with rheumatologic and neurological cardinal disease features.<\/a> 
Zielonka M, Garbade SF, K\u00f6lker S, Hoffmann GF, Ries M.
Genet Med. 2017 Oct 19. doi: 10.1038\/gim.2017.133. PMID:29048419<\/p>\n\n\n\n

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells.<\/a>
Schweizer PA, Darche FF, Ullrich ND, Geschwill P, Greber B, Rivinius R, Seyler C, M\u00fcller-Decker K, Draguhn A, Utikal J, Koenen M, Katus HA, Thomas D.
Stem Cell Res Ther. 2017 Oct 16;8(1):229. doi: 10.1186\/s13287-017-0681-4. PMID: 29037217<\/p>\n\n\n\n

Fully digital data processing during cardiovascular implantable electronic device follow-up in a high-volume tertiary center.<\/a> 
Staudacher I, Nalpathamkalam AR, Uhlmann L, Illg C, Seehausen S, Akhavanpoor M, Buchauer A, Geis N, Lugenbiel P, Schweizer PA, Xynogalos P, Zylla MM, Scholz E, Zitron E, Katus HA, Thomas D. 
Eur J Med Res. 2017 Oct 11;22(1):41. doi: 10.1186\/s40001-017-0284-7. PMID:29020984<\/p>\n\n\n\n

Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis<\/a>
S\u00e9bastien Boutin, Simon Y. Graeber, Mirjam Stahl, A. Susanne Dittrich, Marcus A. Mall, Alexander H. Dalpke
Eur Respir J. 2017 Oct 5;50(4). pii: 1701086. doi: 10.1183\/13993003.01086-2017. Print 2017 Oct. PMID:28982777<\/p>\n\n\n\n

Dual function of UPF3B in early and late translation termination<\/a>
Gabriele Neu-Yilik, Etienne Raimondeau, Boris Eliseev, Lahari Yeramala, Beate Amthor, Aur\u00e9lien Deniaud, Karine Huard, Kathrin Kerschgens, Matthias W. Hentze, Christiane Schaffitzel, Andreas E. Kulozik
EMBO J. 2017 Sep 12. pii: e201797079. doi: 10.15252\/embj.201797079. [Epub ahead of print]PMID:28899899<\/p>\n\n\n\n

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.<\/a> 
Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H. 
Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038\/s41467-017-00500-z.PMID: 28864822<\/p>\n\n\n\n

miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels.<\/a>Gandla J, Lomada SK, Lu J, Kuner R, Bali KK. 
Pain. 2017 Sep;158(9):1765-1779. doi: 10.1097\/j.pain.0000000000000971. PMID: 28614186<\/p>\n\n\n\n

Low-iron diet and chelation therapy rescue severe atherosclerosis associated with high circulating iron levels<\/a> 
Francesca Vinchi, Richard Sparla, Andreas Simmelbauer, Sandro Altamura, Sebastian Speich, Bruno Galy, Matthias W. Hentze, Martina U. Muckenthaler
Atherosclerosis, Volume 263, August 2017, Pages e15-e16<\/p>\n\n\n\n

Elevated systemic heme and iron levels as risk factor for vascular dysfunction and atherosclerosis: Evidence from a beta-thalassemia cohort study<\/a> 
Francesca Vinchi, Gregory M. Vercellotti, John D. Belcher, Richard Sparla, Eitan Fibach, Hala Zreid, Rushdy Rasras, Hussam Ghoti, Martina U. Muckenthaler, Eliezer A. Rachmilewitz 
Atherosclerosis, August 2017, Volume 263, Pages e107\u2013e108<\/p>\n\n\n\n

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.<\/a>Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicu\u00f1a L, Offermanns S, Kuner R. 
Nat Commun. 2017 Aug 2;8(1):176. doi: 10.1038\/s41467-017-00341-w. PMID: 28765520<\/p>\n\n\n\n

NOTCH1<\/em> mutation, TP53<\/em> alteration and myeloid antigen expression predict outcome heterogeneity in children with first relapse of T-cell acute lymphoblastic leukemia.<\/a> 
Hof J, Kox C, Groeneveld-Krentz S, Bandapalli OR, Karawajew L, Schedel K, Kunz JB, Eckert C, Ludwig WD, Ratei R, Rhein P, Henze G, Muckenthaler MU, Kulozik AE, von Stackelberg A, Kirschner-Schwabe R.
Haematologica. 2017 Jul;102(7):e249-e252. doi: 10.3324\/haematol.2016.157792. Epub 2017 Mar 30.PMID:28360149<\/p>\n\n\n\n

No changes in heme synthesis in human Friedreich\u00b4s ataxia erythroid progenitor cells.<\/a>
Steinkellner H, Singh HN, Muckenthaler MU, Goldenberg H, Moganty RR, Scheiber-Mojdehkar B, Sturm B.
Gene. 2017 Jul 20;621:5-11. doi: 10.1016\/j.gene.2017.04.014. Epub 2017 Apr 12. PMID: 28412459<\/p>\n\n\n\n

Imatinib and spironolactone suppress hepcidin expression.<\/a> 
Mleczko-Sanecka K, da Silva AR, Call D, Neves J, Schmeer N, Damm G, Seehofer D, Muckenthaler MU.
Haematologica. 2017 Jul;102(7):1173-1184. doi: 10.3324\/haematol.2016.162917. Epub 2017 Apr 6.PMID:28385785<\/p>\n\n\n\n

Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis.<\/a> 
Metzendorf C, Zeigerer A, Seifert S, Sparla R, Najafi B, Canonne-Hergaux F, Zerial M, Muckenthaler MU.
Sci Rep. 2017 Jun 22;7(1):4023. doi: 10.1038\/s41598-017-02898-4.PMID:28642463<\/p>\n\n\n\n

Disruption of the Hepcidin\/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.<\/a> 
Neves J, Leitz D, Kraut S, Brandenberger C, Agrawal R, Weissmann N, M\u00fchlfeld C, Mall MA, Altamura S, Muckenthaler MU.
EBioMedicine. 2017 Jun;20:230-239. doi: 10.1016\/j.ebiom.2017.04.036. Epub 2017 Apr 29.PMID:28499927<\/p>\n\n\n\n

Abstract: 
WS02.2 Role of soluble and membrane-associated neutrophil elastase activity in cystic fibrosis sputum<\/a>. 
Dittrich, A. Susanne & K\u00fchbandner, I & Gehrig, Stefanie & Rickert-Zacharias, V & Taggart, Cliff & Twigg, Matthew & Herth, Felix & Schultz, C & Mall, Marcus. 
Journal of Cystic Fibrosis. June 2017 16. S3. 10.1016\/S1569-1993(17)30163-7.<\/p>\n\n\n\n

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging<\/a>
Hoffmann A, Helluy X, Fischer M, Mueller AK, Heiland S, Pham M, Bendszus M, Pfeil J
J. Vis. Exp. 2017 (124), e55334, doi:10.3791\/55334<\/p>\n\n\n\n

Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin.<\/a>
da Silva AR, Neves J, Mleczko-Sanecka K, Tandon A, Sauer SW, Hentze MW, Muckenthaler MU.
J Mol Med (Berl). 2017 Jun 5. doi: 10.1007\/s00109-017-1551-3. PMID: 28585096<\/p>\n\n\n\n

Cdk6 contributes to cytoskeletal stability in erythroid cells.<\/a> 
Uras IZ, Scheicher RM, Kollmann K, Gl\u00f6smann M, Prchal-Murphy M, Tigan AS, Fux DA, Altamura S, Neves J, Muckenthaler MU, Bennett KL, Kubicek S, Hinds PW, von Lindern M, Sexl V.
Haematologica. 2017 Jun;102(6):995-1005. doi: 10.3324\/haematol.2016.159947. Epub 2017 Mar 2.PMID:28255017<\/p>\n\n\n\n

Systematic Cell-Based Phenotyping of Missense Alleles.<\/a> 
Thorm\u00e4hlen AS, Runz H. 
Methods Mol Biol. 2017;1601:215-228. doi: 10.1007\/978-1-4939-6960-9_17.PMID:28470529<\/p>\n\n\n\n

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention<\/a>.
Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP.
Int J Mol Sci. 2017 May 5;18(5). pii: E984. doi: 10.3390\/ijms18050984. Review.PMID:28475116<\/p>\n\n\n\n

Pathophysiological consequences and benefits of HFE<\/em> mutations: 20 years of research.<\/a> 
Hollerer I, Bachmann A, Muckenthaler MU.
Haematologica. 2017 May;102(5):809-817. doi: 10.3324\/haematol.2016.160432. Epub 2017 Mar 9. Review.PMID:28280078<\/p>\n\n\n\n

Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes – What We Know so Far and the Missing Links.<\/a> 
Groener JB, Oikonomou D, Cheko R, Kender Z, Zemva J, Kihm L, Muckenthaler M, Peters V, Fleming T, Kopf S, Nawroth PP.
Exp Clin Endocrinol Diabetes. 2017 Apr 13. doi: 10.1055\/s-0043-106443.PMID:28407670<\/p>\n\n\n\n

A Distinct Cardiomyopathy: HCN4 Syndrome Comprising Myocardial Noncompaction, Bradycardia, Mitral Valve Defects, and Aortic Dilation.<\/a>Schweizer PA, Koenen M, Katus HA, Thomas D.
J Am Coll Cardiol. 2017 Mar 7;69(9):1209-1210. doi: 10.1016\/j.jacc.2016.10.085. PMID:28254188<\/p>\n\n\n\n

Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia.<\/a>
Richter-Pecha\u0144ska P, Kunz JB, Hof J, Zimmermann M, Rausch T, Bandapalli OR, Orlova E, Scapinello G, Sagi JC, Stanulla M, Schrappe M, Cario G, Kirschner-Schwabe R, Eckert C, Benes V, Korbel JO, Muckenthaler MU, Kulozik AE.
Blood Cancer J. 2017 Feb 3;7(2):e523. doi: 10.1038\/bcj.2017.3. PMID: 28157215<\/p>\n\n\n\n

A Red Carpet for Iron Metabolism.<\/a>
Muckenthaler MU, Rivella S, Hentze MW, Galy B. 
Cell. 2017 Jan 26;168(3):344-361. doi: 10.1016\/j.cell.2016.12.034. Review. PMID: 28129536<\/p>\n\n\n\n

TREK-1 (K2P2.1) K+ channels are suppressed in patients with atrial fibrillation and heart failure and provide therapeutic targets for rhythm control.<\/a> 
Lugenbiel P, Wenz F, Syren P, Geschwill P, Govorov K, Seyler C, Frank D, Schweizer PA, Franke J, Weis T, Bruehl C, Schmack B, Ruhparwar A, Karck M, Frey N, Katus HA, Thomas D. 
Basic Res Cardiol. 2017 Jan;112(1):8. doi: 10.1007\/s00395-016-0597-7. PMID: 28005193<\/p>\n\n\n\n

Insights into the design and interpretation of iCLIP experiments.<\/a>
Haberman N, Huppertz I, Attig J, K\u00f6nig J, Wang Z, Hauer C, Hentze MW, Kulozik AE, Le Hir H, Curk T, Sibley CR, Zarnack K, Ule J. 
Genome Biol. 2017 Jan 16;18(1):7. doi: 10.1186\/s13059-016-1130-x. PMID: 28093074<\/p>\n\n\n\n

Reverse-transcription loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus directly from nasopharyngeal swabs.<\/a>
Hoos J, Peters RM, Tabatabai J, Grulich-Henn J, Schnitzler P, Pfeil J. 
J Virol Methods. 2017 Jan 16;242:53-57. doi: 10.1016\/j.jviromet.2017.01.006. [Epub ahead of print] PMID: 28093275<\/p>\n\n\n\n

Evaluation of Alere\u2122 i RSV for rapid detection of respiratory syncytial virus in children hospitalized with acute respiratory tract infection.<\/a>
Peters RM, Schnee SV, Tabatabai J, Schnitzler P, Pfeil J.
J Clin Microbiol. 2017 Jan 11. pii: JCM.02433-16. doi: 10.1128\/JCM.02433-16. [Epub ahead of print] PMID: 28077700<\/p>\n\n\n\n

Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms.<\/a>
Enculescu M, Metzendorf C, Sparla R, Hahnel M, Bode J, Muckenthaler MU, Legewie S. 
PLoS Comput Biol. 2017 Jan 9;13(1):e1005322. doi: 10.1371\/journal.pcbi.1005322. 
PMID: 28068331<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2016<\/summary>\n
\n\n

The structure and flexibility of conical HIV-1 capsids determined within intact virions.<\/a>
Mattei S, Glass B, Hagen WJ, Kr\u00e4usslich HG, Briggs JA. 
Science. 2016 Dec 16;354(6318):1434-1437. 
PMID: 27980210<\/p>\n\n\n\n

Acetylated tubulin is essential for touch sensation in mice.<\/a>
Morley SJ, Qi Y, Iovino L, Andolfi L, Guo D, Kalebic N, Castaldi L, Tischer C, Portulano C, Bolasco G, Shirlekar K, Fusco CM, Asaro A, Fermani F, Sundukova M, Matti U, Reymond L, De Ninno A, Businaro L, Johnsson K, Lazzarino M, Ries J, Schwab Y, Hu J, Heppenstall PA. 
Elife. 2016 Dec 13;5. pii: e20813. doi: 10.7554\/eLife.20813.
PMID: 27976998<\/p>\n\n\n\n

Neutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung disease.<\/a> 
Wagner CJ, Schultz C, Mall MA. 
Mol Cell Pediatr. 2016 Dec;3(1):25. doi: 10.1186\/s40348-016-0053-7. Epub 2016 Jul 25. Review<\/p>\n\n\n\n

Antiarrhythmic gene therapy – will biologics replace catheters, drugs and devices?<\/a>
Lugenbiel P, Schweizer PA, Katus HA, Thomas D. 
Eur J Pharmacol. 2016 Nov 15;791:264-273. doi: 10.1016 \/ j.ejphar.2016.09.001. Review.<\/p>\n\n\n\n

In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis.<\/a>
Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Kr\u00fcwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO. 
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):13227-13232.<\/p>\n\n\n\n

Post-transplant cyclophosphamide-based haplo-identical transplantation as alternative to matched sibling or unrelated donor transplantation for non-Hodgkin lymphoma: a registry study by the European society for blood and marrow transplantation.<\/a>
Dietrich S, Finel H, Martinez C, Tischer J, Blaise D, Chevallier P, Castagna L, Milpied N, Bacigalupo A, Corradini P, Mohty M, Sanz M, Hausmann A, Montoto S, Robinson S, Boumendil A, Sureda A, Dreger P.
Leukemia. 2016 Oct;30(10):2086-2089. doi: 10.1038\/leu.2016.125<\/p>\n\n\n\n

CTNNB1-mutant colorectal carcinomas with immediate invasive growth: a model of interval cancers in Lynch syndrome.<\/a> 
Ahadova A, von Knebel Doeberitz M, Bl\u00e4ker H, Kloor M. 
Fam Cancer. 2016 Oct;15(4):579-86. doi: 10.1007\/s10689-016-9899-z.<\/p>\n\n\n\n

Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression.<\/a>
Kim DK, Kim YH, Jung YS, Kim KS, Jeong JH, Lee YS, Yuk JM, Oh BC, Choy HE, Dooley S, Muckenthaler MU, Lee CH, Choi HS. 
Sci Rep. 2016 Sep 30;6:34630. doi: 10.1038\/srep34630.<\/p>\n\n\n\n

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells.<\/a> 
Ebrahimi-Fakhari D, Wahlster L, Bartz F, Werenbeck-Ueding J, Praggastis M, Zhang J, Joggerst-Thomalla B, Theiss S, Grimm D, Ory DS, Runz H.
Hum Mol Genet. 2016 Aug 15;25(16):3588-3599. doi: 10.1093\/hmg\/ddw204. Epub 2016 Jul 4.PMID:27378690<\/p>\n\n\n\n

MOCAT2: a metagenomic assembly, annotation and profiling framework.<\/a> 
Kultima JR, Coelho LP, Forslund K, Huerta-Cepas J, Li SS, Driessen M, Voigt AY, Zeller G, Sunagawa S, Bork P. 
Bioinformatics. 2016 Aug 15;32(16):2520-3. doi: 10.1093\/bioinformatics\/btw183. Epub 2016 Apr 8.<\/p>\n\n\n\n

The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.<\/a>
Song K, Wang H, Kamm GB, Pohle J, de Castro Reis F, Heppenstall P, Wende H, Siemens J. 
Science. 2016 Aug 25. pii: aaf7537. [Epub ahead of print] PMID: 27562954<\/p>\n\n\n\n

Exon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.<\/a> 
Hauer C, Sieber J, Schwarzl T, Hollerer I, Curk T, Alleaume AM, Hentze MW, Kulozik AE. 
Cell Rep. 2016 Aug 9;16(6):1588-603. doi: 10.1016\/j.celrep.2016.06.096. Epub 2016 Jul 28.<\/p>\n\n\n\n

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation.<\/a> 
Schur FK, Obr M, Hagen WJ, Wan W, Jakobi AJ, Kirkpatrick JM, Sachse C, Kr\u00e4usslich HG, Briggs JA. 
Science. 2016 Jul 29;353(6298):506-8. doi: 10.1126\/science.aaf9620. Epub 2016 Jul 14.<\/p>\n\n\n\n

5-aza-2′-deoxycytidine (DAC) treatment downregulates the HPV E6 and E7 oncogene expression and blocks neoplastic growth of HPV-associated cancer cells.<\/a>
Stich M, Ganss L, Puschhof J, Prigge ES, Reuschenbach M, Guiterrez A, Vinokurova S, von Knebel Doeberitz M. 
Oncotarget. 2016 Jul 16. doi: 10.18632\/oncotarget.10631. [Epub ahead of print]<\/p>\n\n\n\n

CRLF2 over-expression is a poor prognostic marker in children with high risk T-cell acute lymphoblastic leukemia.<\/a> 
Palmi C, Savino AM, Silvestri D, Bronzini I, Cario G, Paganin M, Buldini B, Galbiati M, Muckenthaler MU, Bugarin C, Mina PD, Nagel S, Barisone E, Casale F, Locatelli F, Nigro LL, Micalizzi C, Parasole R, Pession A, Putti MC, Santoro N, Testi AM, Ziino O, Kulozik AE, Zimmermann M, Schrappe M, Villa A, Gaipa G, Basso G, Biondi A, Valsecchi MG, Stanulla M, Conter V, Kronnie GT, Cazzaniga G. 
Oncotarget. 2016 Jul 15. doi: 10.18632\/oncotarget.10610.<\/p>\n\n\n\n

The differential expression of alternatively polyadenylated transcripts is a common stress-induced response mechanism that modulates mammalian mRNA expression in a quantitative and qualitative fashion.<\/a> 
Hollerer I, Curk T, Haase B, Benes V, Hauer C, Neu-Yilik G, Bhuvanagiri M, Hentze MW, Kulozik AE. 
RNA. 2016 Jul 12. [Epub ahead of print] 
PMID: 27407180<\/p>\n\n\n\n

Human gut microbes impact host serum metabolome and insulin sensitivity.<\/a> 
Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Dor\u00e9 J, Mattila I, Plichta DR, P\u00f6h\u00f6 P, Hellgren LI, Arumugam M, Sunagawa S, Vieira-Silva S, J\u00f8rgensen T, Holm JB, Tro\u0161t K; MetaHIT Consortium, Kristiansen K, Brix S, Raes J, Wang J, Hansen T, Bork P, Brunak S, Oresic M, Ehrlich SD, Pedersen O. 
Nature. 2016 Jul 21;535(7612):376-81.<\/p>\n\n\n\n

High-Density Peptide Arrays for Malaria Vaccine Development.<\/a> Loeffler FF, Pfeil J, Heiss K. 
Methods Mol Biol. 2016;1403:569-82. doi: 10.1007\/978-1-4939-3387-7_32. PMID: 27076154<\/p>\n\n\n\n

New hardware and workflows for semi-automated correlative cryo-fluorescence and cryo-electron microscopy\/tomography.<\/a> 
Schorb M, Gaechter L, Avinoam O, Sieckmann F, Clarke M, Bebeacua C, Bykov YS, Sonnen AF, Lihl R, Briggs JA. 
J Struct Biol. 2016 Jun 28. pii: S1047-8477(16)30135-6. doi: 10.1016\/j.jsb.2016.06.020. [Epub ahead of print] PMID: 27368127<\/p>\n\n\n\n

TMEM16F Regulates Spinal Microglial Function in Neuropathic Pain States.<\/a>
Batti L, Sundukova M, Murana E, Pimpinella S, De Castro Reis F, Pagani F, Wang H, Pellegrino E, Perlas E, Di Angelantonio S, Ragozzino D, Heppenstall PA. 
Cell Rep. 2016 Jun 21;15(12):2608-15. doi: 10.1016\/j.celrep.2016.05.039. PMID: 27332874<\/p>\n\n\n\n

Transforming Growth Factor \u03b21 (TGF-\u03b21) Activates Hepcidin mRNA Expression in Hepatocytes.<\/a> 
Chen S, Feng T, Vuji\u0107 Spasi\u0107 M, Altamura S, Breitkopf-Heinlein K, Alten\u00f6der J, Weiss TS, Dooley S, Muckenthaler MU. 
J Biol Chem. 2016 Jun 17;291(25):13160-74. doi: 10.1074\/jbc.M115.691543. Epub 2016 Apr 27.<\/p>\n\n\n\n

Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations<\/a>.
Vermeer AM, Lodder EM, Thomas D, Duijkers FA, Marcelis C, van Gorselen EO, Fortner P, Buss SJ, Mereles D, Katus HA, Wilde AA, Bezzina CR, Boekholdt SM, Schweizer PA, Christiaans I.
J Am Coll Cardiol. 2016 May 17;67(19):2313-5. doi: 10.1016\/j.jacc.2016.01.086.<\/p>\n\n\n\n

Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing.<\/a> 
Vogtmann E, Hua X, Zeller G, Sunagawa S, Voigt AY, Hercog R, Goedert JJ, Shi J, Bork P, Sinha R. 
PLoS One. 2016 May 12;11(5):e0155362. doi: 10.1371\/journal.pone.0155362. eCollection 2016.<\/p>\n\n\n\n

A subpopulation of itch-sensing neurons marked by Ret and somatostatin expression.<\/a>
Stantcheva KK, Iovino L, Dhandapani R, Martinez C, Castaldi L, Nocchi L, Perlas E, Portulano C, Pesaresi M, Shirlekar KS, de Castro Reis F, Paparountas T, Bilbao D, Heppenstall PA. 
EMBO Rep. 2016 Apr;17(4):585-600. doi: 10.15252\/embr.201540983. Epub 2016 Feb 29. PMID: 26929027<\/p>\n\n\n\n

Durable coexistence of donor and recipient strains after fecal microbiota transplantation.<\/a> 
Li SS, Zhu A, Benes V, Costea PI, Hercog R, Hildebrand F, Huerta-Cepas J, Nieuwdorp M, Saloj\u00e4rvi J, Voigt AY, Zeller G, Sunagawa S, de Vos WM, Bork P. 
Science. 2016 Apr 29;352(6285):586-9. doi: 10.1126\/science.aad8852.<\/p>\n\n\n\n

Nucleic Acid Binding by Mason-Pfizer Monkey Virus CA Promotes Virus Assembly and Genome Packaging.<\/a> 
F\u00fczik T, P\u00edchalov\u00e1 R, Schur FK, Strohalmov\u00e1 K, K\u0159\u00ed\u017eov\u00e1 I, Hadravov\u00e1 R, Rumlov\u00e1 M, Briggs JA, Ulbrich P, Ruml T. 
J Virol. 2016 Apr 14;90(9):4593-603. doi: 10.1128\/JVI.03197-15. Print 2016 May 1. PMID: 26912613<\/p>\n\n\n\n

A saposin-lipoprotein nanoparticle system for membrane proteins.<\/a> 
Frauenfeld J, L\u00f6ving R, Armache JP, Sonnen AF, Guettou F, Moberg P, Zhu L, Jegersch\u00f6ld C, Flayhan A, Briggs JA, Garoff H, L\u00f6w C, Cheng Y, Nordlund P. 
Nat Methods. 2016 Apr;13(4):345-51. doi: 10.1038\/nmeth.3801. Epub 2016 Mar 7. PMID: 26950744<\/p>\n\n\n\n

Cellular apoptosis susceptibility (CAS) is linked to integrin \u03b21 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).<\/a>
Winkler J, Roessler S, Sticht C, DiGuilio AL, Drucker E, Holzer K, Eiteneuer E, Herpel E, Breuhahn K, Gretz N, Schirmacher P, Ori A, Singer S. 
Oncotarget. 2016 Mar 23. doi: 10.18632\/oncotarget.8256. [Epub ahead of print] PMID: 27015362<\/p>\n\n\n\n

miR-20a regulates expression of the iron exporter ferroportin in lung cancer.<\/a> 
Babu KR, Muckenthaler MU. 
J Mol Med (Berl). 2016 Mar;94(3):347-59. doi: 10.1007\/s00109-015-1362-3. Epub 2015 Nov 12<\/p>\n\n\n\n

Retrovirus maturation-an extraordinary structural transformation.<\/a> 
Mattei S, Schur FK, Briggs JA. 
Curr Opin Virol. 2016 Mar 21;18:27-35. doi: 10.1016\/j.coviro.2016.02.008. [Epub ahead of print] Review. PMID: 27010119<\/p>\n\n\n\n

Spatiotemporal variation of mammalian protein complex stoichiometries.<\/a>
Ori A, Iskar M, Buczak K, Kastritis P, Parca L, Andr\u00e9s-Pons A, Singer S, Bork P, Beck M. 
Genome Biol. 2016 Mar 14;17:47. doi: 10.1186\/s13059-016-0912-5. PMID: 26975353<\/p>\n\n\n\n

A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing.<\/a>
Eliava M, Melchior M, Knobloch-Bollmann HS, Wahis J, da Silva Gouveia M, Tang Y, Ciobanu AC, Triana del Rio R, Roth LC, Althammer F, Chavant V, Goumon Y, Gruber T, Petit-Demouli\u00e8re N, Busnelli M, Chini B, Tan LL, Mitre M, Froemke RC, Chao MV, Giese G, Sprengel R, Kuner R, Poisbeau P, Seeburg PH, Stoop R, Charlet A, Grinevich V.
Neuron. 2016 Mar 16;89(6):1291-304. doi: 10.1016\/j.neuron.2016.01.041.<\/p>\n\n\n\n

Functional characterization of a mouse model for central post-stroke pain.<\/a> 
Gritsch S, Bali KK, Kuner R, Vardeh D. 
Mol Pain. 2016 Mar 8;12. pii: 1744806916629049. doi: 10.1177\/1744806916629049.<\/p>\n\n\n\n

Proteomic analysis reveals branch-specific regulation of the unfolded protein response by nonsense-mediated mRNA decay<\/a>
Sieber, J., Hauer, C., Bhuvanagiri, M., Leicht, S., Krijgsveld, J., Neu-Yilik, G., Hentze, M.W., Kulozik, A.E. 
Molecular & Cellular Proteomics 2016 Feb 20 pii: mcp.M115.054056.<\/p>\n\n\n\n

Mice with hepcidin-resistant ferroportin accumulate iron in the retina<\/a>. 
Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, Galy B, Hentze M, Muckenthaler MU, Dunaief JL.
FASEB J. 2016 Feb;30(2):813-23. doi: 10.1096\/fj.15-276758. Epub 2015 Oct 27. PMID: 26506980<\/p>\n\n\n\n

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease.<\/a> 
Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, Cerwenka A, Tolosano E, Muckenthaler MU. 
Blood. 2016 Jan 28;127(4):473-86. doi: 10.1182\/blood-2015-08-663245. Epub 2015 Dec 16.<\/p>\n\n\n\n

The orchestra of lipid-transfer proteins at the crossroads between metabolism and signaling.<\/a> 
Chiapparino A, Maeda K, Turei D, Saez-Rodriguez J, Gavin AC.
Prog Lipid Res. 2016 Jan;61:30-9. doi: 10.1016\/j.plipres.2015.10.004. Epub 2015 Dec 1. Review.PMID:26658141<\/p>\n\n\n\n

Efficacy and safety of deferasirox in non-thalassemic patients with elevated ferritin levels after allogeneic hematopoietic stem cell transplantation.<\/a> 
Jaekel N, Lieder K, Albrecht S, Leismann O, Hubert K, Bug G, Kr\u00f6ger N, Platzbecker U, Stadler M, de Haas K, Altamura S, Muckenthaler MU, Niederwieser D, Al-Ali HK. 
Bone Marrow Transplant. 2016 Jan;51(1):89-95. doi: 10.1038\/bmt.2015.204. Epub 2015 Sep 14.<\/p>\n\n\n\n

Gut Microbiota Linked to Sexual Preference and HIV Infection.<\/a> 
Noguera-Julian M, Rocafort M, Guill\u00e9n Y, Rivera J, Casadell\u00e0 M, Nowak P, Hildebrand F, Zeller G, Parera M, Bellido R, Rodr\u00edguez C, Carrillo J, Mothe B, Coll J, Bravo I, Estany C, Herrero C, Saz J, Sirera G, Torrela A, Navarro J, Crespo M, Brander C, Negredo E, Blanco J, Guarner F, Calle ML, Bork P, S\u00f6nnerborg A, Clotet B, Paredes R. 
EBioMedicine. 2016 Jan 28;5:135-46. doi: 10.1016\/j.ebiom.2016.01.032. eCollection 2016 Mar.<\/p>\n\n\n\n

eggNOG 4.5: a hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.<\/a> 
Huerta-Cepas J, Szklarczyk D, Forslund K, Cook H, Heller D, Walter MC, Rattei T, Mende DR, Sunagawa S, Kuhn M, Jensen LJ, von Mering C, Bork P. 
Nucleic Acids Res. 2016 Jan 4;44(D1):D286-93. doi: 10.1093\/nar\/gkv1248. Epub 2015 Nov 17. PMID: 26582926<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2015<\/summary>\n
\n\n

The systematic analysis of protein-lipid interactions comes of age.<\/a> 
Saliba AE, Vonkova I, Gavin AC. 
Nat Rev Mol Cell Biol. 2015 Dec;16(12):753-61. doi: 10.1038\/nrm4080. Epub 2015 Oct 28. PMID: 26507169<\/p>\n\n\n\n

BRAF inhibitor therapy in HCL.<\/a> 
Dietrich S, Zenz T. 
Best Pract Res Clin Haematol. 2015 Dec;28(4):246-52. doi: 10.1016\/j.beha.2015.10.001. Epub 2015 Oct 20. Review. PMID:26614903<\/p>\n\n\n\n

A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition.<\/a>
Stockklausner C, Raffel S, Klermund J, Bandapalli OR, Beier F, Br\u00fcmmendorf TH, B\u00fcrger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B, Trumpp A, Kulozik AE.
Aging (Albany NY). 2015 Nov;7(11):911-27. PMID:26546739<\/p>\n\n\n\n

The Structure of Immature Virus-Like Rous Sarcoma Virus Gag Particles Reveals a Structural Role for the p10 Domain in Assembly.<\/a> 
Schur FK, Dick RA, Hagen WJ, Vogt VM, Briggs JA. 
J Virol. 2015 Oct;89(20):10294-302. doi: 10.1128\/JVI.01502-15. Epub 2015 Jul 29. PMID: 26223638<\/p>\n\n\n\n

Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer.<\/a> 
Echterdiek F, Janikovits J, Staffa L, M\u00fcller M, Lahrmann B, Fr\u00fchsch\u00fctz M, Hartog B, Nelius N, Benner A, Tariverdian M, von Knebel Doeberitz M, Grabe N, Kloor M. 
Oncoimmunology. 2015 Nov 11;5(2):e1075692. eCollection 2016 Feb.<\/p>\n\n\n\n

Lipid Cooperativity as a General Membrane-Recruitment Principle for PH Domains.<\/a> 
Vonkova I, Saliba AE, Deghou S, Anand K, Ceschia S, Doerks T, Galih A, Kugler KG, Maeda K, Rybin V, van Noort V, Ellenberg J, Bork P, Gavin AC. 
Cell Rep. 2015 Sep 1;12(9):1519-30. doi: 10.1016\/j.celrep.2015.07.054. Epub 2015 Aug 20. PMID: 26299969<\/p>\n\n\n\n

Pediatric T-lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.<\/a> Kunz JB, Rausch T, Bandapalli OR, Eilers J, Pechanska P, Schuessele S, Assenov Y, St\u00fctz AM, Kirschner-Schwabe R, Hof J, Eckert C, von Stackelberg A, Schrappe M, Stanulla M, Koehler R, Avigad S, Elitzur S, Handgretinger R, Benes V, Weischenfeldt J, Korbel JO, Muckenthaler MU, Kulozik AE.
Haematologica. 2015 Aug 20. pii: haematol.2015.129692. [Epub ahead of print] PMID: 26294725<\/p>\n\n\n\n

Improved binding site assignment by high-resolution mapping of RNA-protein interactions using iCLIP.<\/a>
Hauer C, Curk T, Anders S, Schwarzl T, Alleaume AM, Sieber J, Hollerer I, Bhuvanagiri M, Huber W, Hentze MW, Kulozik AE. 
Nat Commun. 2015 Aug 11;6:7921. doi: 10.1038\/ncomms8921. PMID: 26260686<\/p>\n\n\n\n

Recurrent CDKN1B (p27) mutations in hairy cell leukemia.<\/a> 
Dietrich S, H\u00fcllein J, Lee SC, Hutter B, Gonzalez D, Jayne S, Dyer MJ, Ole\u015b M, Else M, Liu X, S\u0142abicki M, Wu B, Troussard X, D\u00fcrig J, Andrulis M, Dearden C, von Kalle C, Granzow M, Jauch A, Fr\u00f6hling S, Huber W, Meggendorfer M, Haferlach T, Ho AD, Richter D, Brors B, Glimm H, Matutes E, Abdel Wahab O, Zenz T.
Blood. 2015 Aug 20;126(8):1005-8. doi: 10.1182\/blood-2015-04-643361. Epub 2015 Jun 11. PMID: 26065650<\/p>\n\n\n\n

Elevated hepcidin serum level in response to inflammatory and iron signals in exercising athletes is independent of moderate supplementation with vitamin C and E.<\/a> 
D\u00edaz V, Peinado AB, Barba-Moreno L, Altamura S, Butrague\u00f1o J, Gonz\u00e1lez-Gross M, Alteheld B, Stehle P, Zapico AG, Muckenthaler MU, Gassmann M. 
Physiol Rep. 2015 Aug;3(8). pii: e12475. doi: 10.14814\/phy2.12475. PMID: 26243212<\/p>\n\n\n\n

Adaptation of iron requirement to hypoxic conditions at high altitude.<\/a> 
Gassmann M, Muckenthaler MU. 
J Appl Physiol (1985). 2015 Jul 16:jap.00248.2015. doi: 10.1152\/japplphysiol.00248.2015. [Epub ahead of print] PMID: 26183475<\/p>\n\n\n\n

RNA and nucleocapsid are dispensable for mature HIV-1 capsid core assembly<\/a>. 
Mattei S, Flemming A, Anders-\u00d6sswein M, Kr\u00e4usslich HG, Briggs JA, M\u00fcller B. 
J Virol. 2015 Jul 15. pii: JVI.00750-15. [Epub ahead of print] PMID:26178992<\/p>\n\n\n\n

A network of SMG-8, SMG-9 and SMG-1 C-terminal insertion domain regulates UPF1 substrate recruitment and phosphorylation.<\/a> 
Deniaud A, Karuppasamy M, Bock T, Masiulis S, Huard K, Garzoni F, Kerschgens K, Hentze MW, Kulozik AE, Beck M, Neu-Yilik G, Schaffitzel C. 
Nucleic Acids Res. 2015 Jun 30. pii: gkv668.<\/p>\n\n\n\n

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain<\/a>.
Selvaraj D, Gangadharan V, Michalski CW, Kurejova M, St\u00f6sser S, Srivastava K, Schweizerhof M, Waltenberger J, Ferrara N, Heppenstall P, Shibuya M, Augustin HG, Kuner R.
Cancer Cell. 2015 Jun 8;27(6):780-96. doi: 10.1016\/j.ccell.2015.04.017.
PMID:26058077<\/p>\n\n\n\n

Retroviral proteases and their roles in virion maturation.<\/a>
Konvalinka J, Kr\u00e4usslich HG, M\u00fcller B.
Virology. 2015 May;479-480:403-17. doi: 10.1016\/j.virol.2015.03.021. Epub 2015 Mar 26. Review. PMID: 25816761<\/p>\n\n\n\n

Histone Deacetylase Inhibitors (HDACi) Cause the Selective Depletion of Bromodomain Containing Proteins (BCPs).<\/a> 
Mackmull MT, Iskar M, Parca L, Singer S, Bork P, Ori A, Beck M. 
Mol Cell Proteomics. 2015 May;14(5):1350-60. doi: 10.1074\/mcp.M114.042499. Epub 2015 Mar 9. PMID: 25755299<\/p>\n\n\n\n

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase<\/a>. 
Vicu\u00f1a L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. 
Nat Med. 2015 May;21(5):518-23. doi: 10.1038\/nm.3852. Epub 2015 Apr 27.PMID:25915831<\/p>\n\n\n\n

The best of 25 years: mRNA 3’end processing.<\/a> 
Hollerer I, Kulozik AE. 
RNA. 2015 Apr;21(4):640-1. doi: 10.1261\/rna.050062.115<\/p>\n\n\n\n

Quantitative mass spectrometry of posttranslational modifications: keys to confidence.<\/a> 
Hennrich ML, Gavin AC. 
Sci Signal. 2015 Apr 7;8(371):re5. doi: 10.1126\/scisignal.aaa6466. Review. PMID:25852188<\/p>\n\n\n\n

Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo.<\/a> 
Costa M, Cruz E, Oliveira S, Benes V, Ivacevic T, Silva MJ, Vieira I, Dias F, Fonseca S, Gon\u00e7alves M, Lima M, Leit\u00e3o C, Muckenthaler MU, Pinto J, Porto G. 
PLoS One. 2015 Apr 16;10(4):e0124246. doi: 10.1371\/journal.pone.0124246. eCollection 2015. PMID: 25880808<\/p>\n\n\n\n

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses<\/a>. 
Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R. 
Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038\/ncomms7820. 
PMID:25865668<\/p>\n\n\n\n

Aqueous humor ferritin in hereditary hyperferritinemia cataract syndrome.<\/a>
Lenzhofer M, Schroedl F, Trost A, Kaser-Eichberger A, Wiedemann H, Strohmaier C, Hohensinn M, Strasser M, Muckenthaler MU Grabner G, Aigner E, Reitsamer HA.
Optom Vis Sci. 2015 Apr;92(4 Suppl 1):S40-7. doi: 10.1097\/OPX.0000000000000544. PMID:25756341<\/p>\n\n\n\n

Temporal and technical variability of human gut metagenomes.<\/a> 
Voigt AY, Costea PI, Kultima JR, Li SS, Zeller G, Sunagawa S, Bork P. 
Genome Biol. 2015 Apr 8;16:73. doi: 10.1186\/s13059-015-0639-8. PMID: 25888008<\/p>\n\n\n\n

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia<\/a>.
Guida C, Altamura S, Klein FA, Galy B, Boutros M, Ulmer AJ, Hentze MW, Muckenthaler MU.
Blood. 2015 Apr 2;125(14):2265-75. doi: 10.1182\/blood-2014-08-595256. Epub 2015 Feb 6.
PMID:25662334<\/p>\n\n\n\n

Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells.<\/a>Ahadova A, Gebert J, von Knebel Doeberitz M, Kopitz J, Kloor M.
IUBMB Life. 2015 Mar;67(3):218-26. doi: 10.1002\/iub.1364. Epub 2015 Apr 9. PMID:25854316<\/p>\n\n\n\n

Association of high CD4-positive T cell infiltration with mutations in HLA class II-regulatory genes in microsatellite-unstable colorectal cancer.<\/a> 
Surmann EM, Voigt AY, Michel S, Bauer K, Reuschenbach M, Ferrone S, von Knebel Doeberitz M, Kloor M.
Cancer Immunol Immunother. 2015 Mar;64(3):357-66. doi: 10.1007\/s00262-014-1638-4. Epub 2014 Dec 2. PMID:25445815<\/p>\n\n\n\n

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor<\/a>. 
Schimer J, P\u00e1vov\u00e1 M, Anders M, Pachl P, \u0160\u00e1cha P, C\u00edgler P, Weber J, Majer P, \u0158ez\u00e1\u010dov\u00e1 P, Kr\u00e4usslich HG, M\u00fcller B, Konvalinka J. 
Nat Commun. 2015 Mar 9;6:6461. doi: 10.1038\/ncomms7461. PMID:25751579<\/p>\n\n\n\n

Iron regulatory protein 1 sustains mitochondrial iron loading and function in frataxin deficiency<\/a>.
Martelli A, Schmucker S, Reutenauer L, Mathieu JR, Peyssonnaux C, Karim Z, Puy H, Galy B, Hentze MW, Puccio H.
Cell Metab. 2015 Feb 3;21(2):311-22. doi: 10.1016\/j.cmet.2015.01.010.
PMID:25651183<\/p>\n\n\n\n

Genetic targeting of chemical indicators in vivo<\/a>.
Yang G, de Castro Reis F, Sundukova M, Pimpinella S, Asaro A, Castaldi L, Batti L, Bilbao D, Reymond L, Johnsson K, Heppenstall PA. 
Nat Methods. 2015 Feb;12(2):137-9. doi: 10.1038\/nmeth.3207. Epub 2014 Dec 8.<\/p>\n\n\n\n

Systematic Cell-Based Phenotyping of Missense Alleles Empowers Rare Variant Association Studies: A Case for LDLR and Myocardial Infarction.<\/a>
Thormaehlen AS, Schuberth C, Won HH, Blattmann P, Joggerst-Thomalla B, Theiss S, Asselta R, Duga S, Merlini PA, Ardissino D, Lander ES, Gabriel S, Rader DJ, Peloso GM, Pepperkok R, Kathiresan S, Runz H. 
PLoS Genet. 2015 Feb 3;11(2):e1004855. doi: 10.1371\/journal.pgen.1004855. eCollection 2015 Feb.PMID:25647241<\/p>\n\n\n\n

Structure of the immature HIV-1 capsid in intact virus particles at 8.8 \u00c5 resolution.<\/a>
Schur FK, Hagen WJ, Rumlov\u00e1 M, Ruml T, M\u00fcller B, Kr\u00e4usslich HG, Briggs JA.
Nature. 2015 Jan 22;517(7535):505-8. doi: 10.1038\/nature13838. Epub 2014 Nov 2. PMID: 25363765<\/p>\n\n<\/div>\n<\/details>\n\n\n\n

\n\n2014<\/summary>\n
\n\n

Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice<\/a>. 
Gritsch S, Lu J, Thilemann S, W\u00f6rtge S, M\u00f6bius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, Kuner R
Nature Communications 2014 Dec 1;5:5472.<\/p>\n\n\n\n

Potential of fecal microbiota for early-stage detection of colorectal cancer.<\/a> Zeller G, Tap J, Voigt AY, Sunagawa S, Kultima JR, Costea PI, Amiot A, B\u00f6hm J, Brunetti F, Habermann N, Hercog R, Koch M, Luciani A, Mende DR, Schneider MA, Schrotz-King P, Tournigand C, Tran Van Nhieu J, Yamada T, Zimmermann J, Benes V, Kloor M, Ulrich CM, von Knebel Doeberitz M, Sobhani I, Bork P. 
Mol Syst Biol. 2014 Nov 28;10:766.doi:10.15252\/msb.20145645.PMID:25432777<\/p>\n\n\n\n

Airway Mucus Obstruction Triggers Macrophage Activation and MMP12-dependent Emphysema<\/a>.<\/a>
Trojanek JB, Cobos-Correa A, Diemer S, Kormann M, Schubert SC, Zhou-Suckow Z, Agrawal R, Duerr J, Wagner CJ, Schatterny J, Hirtz S, Sommerburg O, Hartl D, Schultz C, Mall MA.
Am J Respir Cell Mol Biol. 2014 Nov;51(5):709-20.<\/p>\n\n\n\n

5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion<\/a>.
Bhuvanagiri M, Lewis J, Putzker K, Becker JP, Leicht S, Krijgsveld J, Batra R, Turnwald B, Jovanovic B, Hauer C, Sieber J, Hentze MW, Kulozik AE. 
EMBO Mol Med. 2014 Oct 15. pii: e201404461. doi: 10.15252\/emmm.201404461.<\/p>\n\n\n\n

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.<\/a> 
Bandapalli OR, Schuessele S, Kunz JB, Rausch T, St\u00fctz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE. 
Haematologica. 2014 Oct;99(10):e188-92. doi: 10.3324\/haematol.2014.104992. Epub 2014 Jun 27. No abstract available. PMID:24972766<\/p>\n\n\n\n

Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors<\/a>. 
Woerner SM, Tosti E, Yuan YP, Kloor M, Bork P, Edelmann W, Gebert J. 
Mol Carcinog. 2014 Sep 11. doi: 10.1002\/mc.22213.<\/p>\n\n\n\n

How mutant HFE causes hereditary hemochromatosis.<\/a> 
Muckenthaler MU. 
Blood. 2014 Aug 21;124(8):1212-3. doi: 10.1182\/blood-2014-07-581744. PMID:25147378<\/p>\n\n\n\n

Transmembrane Protein 55B Is a Novel Regulator of Cellular Cholesterol Metabolism.<\/a>
Medina MW, Bauzon F, Naidoo D, Theusch E, Stevens K, Schilde J, Schubert C, Mangravite LM, Rudel LL, Temel RE, Runz H, Krauss RM.
Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1917-23. doi: 10.1161\/ATVBAHA.113.302806. Epub 2014 Jul 17. PMID:25035345<\/p>\n\n\n\n

Noncoding RNAs: key molecules in understanding and treating pain.<\/a>
Bali KK, Kuner R.
Trends Mol Med. 2014 Aug;20(8):437-448. doi: 10.1016\/j.molmed.2014.05.006. Epub 2014 Jun 28. Review.<\/p>\n\n\n\n

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload.<\/a> 
Altamura S, Kessler R, Gr\u00f6ne HJ, Gretz N, Hentze MW, Galy B, Muckenthaler MU.Cell Metab. 2014 Aug 5;20(2):359-67. doi: 10.1016\/j.cmet.2014.07.007.<\/p>\n\n\n\n

A new player in the game: epithelial cathepsin S in early cystic fibrosis lung disease<\/a>
Mall MA, Schultz C.
Am J Respir Crit Care Med. 2014 Jul 15;190(2):126-7. doi: 10.1164\/rccm.201405-0935ED.<\/em><\/p>\n\n\n\n

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways<\/a>. 
Simonetti M, Agarwal N, St\u00f6sser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R.
Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016\/j.neuron.2014.05.037.<\/p>\n\n\n\n

Novel activating mutations lacking cysteine in type I cytokine receptors in acute lymphoblastic leukemia<\/a>.
Shochat C1, Tal N, Gryshkova V, Birger Y, Bandapalli OR, Cazzaniga G, Gershman N, Kulozik AE, Biondi A, Mansour MR, Twizere JC, Muckenthaler MU, Ben-Tal N, Constantinescu SN, Bercovich D, Izraeli S.
Blood. 2014 Jul 3;124(1):106-10.<\/p>\n\n\n\n

Studying ongoing and spontaneous pain in rodents–challenges and opportunities.<\/a>
Tappe-Theodor A, Kuner R.
Eur J Neurosci. 2014 Jun;39(11):1881-90. doi: 10.1111\/ejn.12643. Epub 2014 May 29.<\/p>\n\n\n\n

Cryo-electron microscopy of tubular arrays of HIV-1 Gag resolves structures essential for immature virus assembly<\/a>.
Bharat, T.A., Castillo Menendez, L.R., Hagen, W.J., Lux, V., Igonet, S., Schorb, M., Schur, F.K., Krausslich, H.G. & Briggs, J.A.
Proc Natl Acad Sci U S A. 2014 May 19. pii: 201401455. Europe PMC<\/p>\n\n\n\n

Atherogenesis and iron: from epidemiology to cellular level.<\/a> 
Vinchi F, Muckenthaler MU, Da Silva MC, Balla G, Balla J, Jeney V. 
Front Pharmacol. 2014 May 5;5:94. doi: 10.3389\/fphar.2014.00094. eCollection 2014. Review<\/p>\n\n\n\n

The NC domain of Gag is dispensable for actin incorporation into HIV-1 and for association of viral budding sites with cortical F-actin<\/a>.
Stauffer S1, Rahman SA, de Marco A, Carlson LA, Glass B, Oberwinkler H, Herold N, Briggs JA, M\u00fcller B, Gr\u00fcnewald K, Kr\u00e4usslich HG.J Virol. 2014 Apr 30. [Epub ahead of print]<\/p>\n\n\n\n

Lack of neutrophil elastase reduces inflammation, mucus hypersecretion and emphysema, but not mucus obstruction, in mice with CF-like lung disease<\/a>.
Gehrig S, Duerr J, Weitnauer M, Wagner CJ, Graeber SY, Schatterny J, Hirtz S, Belaaouaj A, Dalpke AH, Schultz C, Mall MA.
Am J Respir Crit Care Med. 2014 Mar 28. [Epub ahead of print]<\/p>\n\n\n\n

Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria<\/a>
Chung J, Anderson SA, Gwynn B, Deck KM, Chen MJ, Langer NB, Shaw GC, Huston NC, Boyer LF, Datta S, Paradkar PN, Li L, Wei Z, Lambert AJ, Sahr K, Wittig JG, Chen W, Lu W, Galy B, Schlaeger TM, Hentze MW, Ward DM, Kaplan J, Eisenstein RS, Peters LL, Paw BH. 
J Biol Chem. 2014 Mar 14;289(11):7835-43. doi: 10.1074\/jbc.M114.547778. Epub 2014 Feb 7. Erratum in: J Biol Chem. 2014 May 16;289(20):13707. PMID:24509859<\/p>\n\n\n\n

Sequencing of a patient with balanced chromosome abnormalities and neurodevelopmental disease identifies disruption of multiple high risk loci by structural variation<\/a>
Blake J, Riddell A, Theiss S, Gonzalez AP, Haase B, Jauch A, Janssen JW, Ibberson D, Pavlinic D, Moog U, Benes V, Runz H.
PLoS One. 2014 Mar 13;9(3):e90894. doi: 10.1371\/journal.pone.0090894. eCollection 2014. PMID:24625750<\/p>\n\n\n\n

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to the proliferative Ras\/RAF and the nutrient-dependent mTOR signaling pathways<\/a>.
Mleczko-Sanecka, K., F. Roche, A.R. da Silva, D. Call, F. D\u2019Allesio, A. Ragab, P.E. Lapinski, R. Ummanni, U. Korf, C. Oakes, G. Damm, L.A. D\u2019Alessandro, U. Klingm\u00fcller, P.D. King, M. Boutros, M.W. Hentze and M.U. Muckenthaler.  
Blood. 2014 Mar 6;123(10):1574-85. doi: 10.1182\/blood-2013-07-515957. Epub 2014 Jan 2.<\/p>\n\n\n\n

FRET-based and other fluorescent proteinase probes<\/a>.
Hu HY, Gehrig S, Reither G, Subramanian D, Mall MA, Plettenburg O, Schultz C.
Biotechnol J. 2014 Feb;9(2):266-81. doi: 10.1002\/biot.201300201. Epub 2014 Jan 27.<\/p>\n\n\n\n

Clinical significance of microsatellite instability in colorectal cancer<\/a>.
Kloor M, Staffa L, Ahadova A, von Knebel Doeberitz M.
Langenbecks Arch Surg. 2014 Jan;399(1):23-31. doi: 10.1007\/s00423-013-1112-3. Epub 2013 Sep 19.<\/p>\n\n\n\n

Comparison of different IRT-PAP protocols to screen newborns for cystic fibrosis in three central European populations.<\/a> 
Sommerburg O, Krulisova V, Hammermann J, Lindner M, Stahl M, Muckenthaler M, Kohlmueller D, Happich M, Kulozik AE, Votava F, Balascakova M, Skalicka V, Stopsack M, Gahr M, Macek M Jr, Mall MA, Hoffmann GF. 
J Cyst Fibros. 2014 Jan;13(1):15-23. doi: 10.1016\/j.jcf.2013.06.003. Epub 2013 Jul 25.  <\/p>\n\n\n\n

A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis.<\/a> 
Casanovas G, Banerji A, d’Alessio F, Muckenthaler MU, Legewie S.
PLoS Comput Biol. 2014 Jan;10(1):e1003421.doi:10.1371\/journal.pcbi.1003421. Epub 2014 Jan2.<\/p>\n\n\n\n

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.<\/a> 
Bandapalli OR, Schuessele S, Kunz JB, Rausch T, St\u00fctz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE. 
Haematologica. 2014 Jun 27. pii: haematol.2014.104992. [Epub ahead of print]<\/p>\n\n\n\n

High CD45 surface expression determines relapse risk in children with precursor B-cell and T-cell acute lymphoblastic leukemia treated according to the ALL-BFM 2000 protocol<\/a>.
Cario G1, Rhein P, Mitl\u00f6hner R, Zimmermann M, Bandapalli OR, Romey R, Moericke A, Ludwig WD, Ratei R, Muckenthaler MU, Kulozik AE, Schrappe M, Stanulla M, Karawajew L.
Haematologica. 2014 Jan;99(1):103-10. doi: 10.3324\/haematol.2013.090225. Epub 2013 Aug 2.<\/p>\n\n\n\n

mRNA 3’end processing: A tale of the tail reaches the clinic<\/a>
Ina Hollerer, Kerstin Grund, Matthias W. Hentze, Andreas E. Kulozik
EMBO Mol Med. 2014 Jan 1;6(1):16-26. doi: 10.1002\/emmm.201303300.<\/p>\n\n<\/div>\n<\/details>\n\n<\/div>\n<\/div>\n\n\n

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To see all publications from a research group please go to the Research Group<\/a> of interest<\/p>\n<\/div>\n\n\n

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