{"id":3683,"date":"2024-01-23T12:07:15","date_gmt":"2024-01-23T12:07:15","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/?page_id=3683"},"modified":"2024-03-15T08:32:48","modified_gmt":"2024-03-15T08:32:48","slug":"co-translational-nascent-chain-modifications-and-their-adaptation-to-cellular-stress","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/research\/co-translational-nascent-chain-modifications-and-their-adaptation-to-cellular-stress\/","title":{"rendered":"Co-translational nascent chain modifications and their adaptation to cellular stress"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h2 class=\"wp-block-heading\">Background<\/h2>\n\n\n\n<p>Covalent protein modifications play key roles in modulating protein function, stability, localization, and interactions. During protein synthesis, some protein modifications have been described, for example acetylation. However, how protein modifications affect co-translational protein folding and homeostasis is an underexplored but an important question in biology.&nbsp;<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<h3 class=\"wp-block-heading\">Project<\/h3>\n\n\n\n<p>Our joint project will characterize the function of co-translational protein modifications (CTMs) on the nascent proteome. We will integrate ribosome profiling (Frydman lab at Stanford), large-scale CRISPR-Cas9 mutagenesis (Steinmetz lab at EMBL), and proteomics (Savitski lab at EMBL) to identify sites of CTMs of nascent chains, and define their function in reshaping and regulating the nascent proteome. This work will establish a new conceptual paradigm on co-translational proteostasis that could be extended to additional modes of co-translational covalent regulation of protein biogenesis. Our work will uncover an underexplored aspect of co-translational proteostasis that may have important implications for pathologies associated to the dysregulation of protein modification and proteostasis, such as aging and neurodegenerative diseases.<\/p>\n\n\n\n<p>This project is supported by a&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/activities\/fellowships\/\" target=\"_blank\">Bridging Excellence Fellowship<\/a>&nbsp;awarded to Maximilian Seidel<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<h2 class=\"wp-block-heading\">Find out more:<\/h2>\n\n\n\n<p>Interested in finding out more?&nbsp;<a rel=\"noreferrer noopener\" href=\"mailto:stanford@embl.de\" target=\"_blank\">Get in touch<\/a>, we would love to hear from you!<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Collaborators:<\/h3>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/Frydman-300x300.jpg\" class=\"vf-profile__image\" alt=\"Headshot Judith Frydman\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/Frydman-300x300.jpg 300w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/Frydman-150x150.jpg 150w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/Frydman.jpg 320w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\n    <h3 class=\"vf-profile__title\" >\n                    <a href=\"https:\/\/web.stanford.edu\/group\/frydman\/web\/\" target=\"_self\" class=\"vf-profile__link\">Frydman Lab<\/a>\n            <\/h3>\n    \n                <p class=\"vf-profile__text\" >\n                Stanford            <\/p>\n    \n    \n      \n\n    \n<\/article>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"155\" height=\"155\" src=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/savitski_misha.jpeg\" class=\"vf-profile__image\" alt=\"Headshot Misha Savitski\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/savitski_misha.jpeg 155w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/savitski_misha-150x150.jpeg 150w\" sizes=\"auto, (max-width: 155px) 100vw, 155px\" \/>\n    <h3 class=\"vf-profile__title\" >\n                    <a href=\"https:\/\/www.embl.org\/groups\/savitski\/\" target=\"_self\" class=\"vf-profile__link\">Savitski Team<\/a>\n            <\/h3>\n    \n                <p class=\"vf-profile__text\" >\n                EMBL            <\/p>\n    \n    \n      \n\n    \n<\/article>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/08\/lars_steinmetz-300x300.jpg\" class=\"vf-profile__image\" alt=\"Headshot Lars Steinmetz\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/08\/lars_steinmetz-300x300.jpg 300w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/08\/lars_steinmetz-150x150.jpg 150w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/08\/lars_steinmetz.jpg 350w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\n    <h3 class=\"vf-profile__title\" >\n                    <a href=\"https:\/\/www.embl.org\/groups\/steinmetz\/\" target=\"_self\" class=\"vf-profile__link\">Steinmetz Group<\/a>\n            <\/h3>\n    \n                <p class=\"vf-profile__text\" >\n                EMBL            <\/p>\n    \n    \n      \n\n    \n<\/article>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<figure class=\"vf-figure wp-block-image  | vf-figure--align vf-figure--align-inline-start   size-medium is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"134\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/BridgingExcellenceLogo_BLACK-300x134.png\" alt=\"Logo Bridging Excellence Fellowships black\" class=\"wp-image-646\" style=\"width:225px;height:101px\" srcset=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/BridgingExcellenceLogo_BLACK-300x134.png 300w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/BridgingExcellenceLogo_BLACK-1024x456.png 1024w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/BridgingExcellenceLogo_BLACK-768x342.png 768w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/BridgingExcellenceLogo_BLACK.png 1064w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"155\" height=\"175\" src=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2024\/01\/Seidel-Max_small.jpeg\" class=\"vf-profile__image\" alt=\"Headshot Max Seidel\" loading=\"lazy\" itemprop=\"image\" \/>\n    <h3 class=\"vf-profile__title\" >\n                    <a href=\"https:\/\/www.embl.org\/people\/person\/maximilian-seidel\/\" target=\"_self\" class=\"vf-profile__link\">Maximilian Seidel<\/a>\n            <\/h3>\n    \n                <p class=\"vf-profile__text\" >\n                Bridging Excellence Fellow            <\/p>\n    \n    \n      \n\n    \n<\/article>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":0,"parent":128,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-3683","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/3683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/comments?post=3683"}],"version-history":[{"count":6,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/3683\/revisions"}],"predecessor-version":[{"id":3697,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/3683\/revisions\/3697"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/128"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/media?parent=3683"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/embl_taxonomy?post=3683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}