{"id":2177,"date":"2023-11-21T13:18:22","date_gmt":"2023-11-21T13:18:22","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/?page_id=2177"},"modified":"2023-11-24T14:50:14","modified_gmt":"2023-11-24T14:50:14","slug":"deciphering-mechanisms-and-rates-of-chromosomal-instability-in-gastric-cancer","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/research\/deciphering-mechanisms-and-rates-of-chromosomal-instability-in-gastric-cancer\/","title":{"rendered":"Deciphering Mechanisms and Rates of Chromosomal Instability in Gastric Cancer"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p>Gastric cancer (GC) is a leading cause of cancer-related death, often detected at advanced stages due to limited screening and slow progression. This project, in collaboration with Stanford and EMBL, aims to understand chromosome instability in GC using a unique longitudinal model. &nbsp;Our approach involves applying innovative single-cell methods, specifically Strand-seq, to a longitudinal GC organoid model that mimics GC development, enabling the analysis of somatic DNA rearrangement processes and their relationship with initial genetic alterations. Ultimately, we seek to uncover the prevalence of and the mechanisms behind chromosomal instability processes, which are a key driver of cancer progression and metastasis.<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<p>This project is supported by an&nbsp;<a href=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/activities\/exchange\/\">Exchange Grant<\/a>, awarded to Aziz Khan and \u00c1lvaro Andrades. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Find out more:<\/h2>\n\n\n\n<p>Interested in finding out more about the bacterial projects? Do you want to join our researchers in the the war on bugs?&nbsp;<a href=\"mailto:stanford@embl.de\" target=\"_blank\" rel=\"noreferrer noopener\">Get in touch<\/a>, we would love to hear from you!<\/p>\n\n\n\n<p><a href=\"https:\/\/med.stanford.edu\/lifesciencealliance\/research\/projects\/bacterials.html#anchor-list\"><\/a><\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Collaborators:<\/h3>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"155\" height=\"155\" src=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/korbel.jpeg\" class=\"vf-profile__image\" alt=\"Headshot Jan Korbel\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/korbel.jpeg 155w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/korbel-150x150.jpeg 150w\" sizes=\"auto, (max-width: 155px) 100vw, 155px\" \/>\n    <h3 class=\"vf-profile__title\" >\n                    <a href=\"https:\/\/www.embl.org\/groups\/korbel\/\" target=\"_self\" class=\"vf-profile__link\">Korbel group<\/a>\n            <\/h3>\n    \n                <p class=\"vf-profile__text\" >\n                EMBL            <\/p>\n    \n    \n      \n\n    \n<\/article>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/curtis-300x300.jpg\" class=\"vf-profile__image\" alt=\"Headshot Christina Curtis\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/curtis-300x300.jpg 300w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/curtis-150x150.jpg 150w, https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-content\/uploads\/2023\/10\/curtis.jpg 320w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\n    <h3 class=\"vf-profile__title\" >\n                    <a href=\"https:\/\/med.stanford.edu\/curtislab.html\" target=\"_self\" class=\"vf-profile__link\">Curstis Lab<\/a>\n            <\/h3>\n    \n                <p class=\"vf-profile__text\" >\n                Stanford            <\/p>\n    \n    \n      \n\n    \n<\/article>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"vf-grid | vf-grid__col-1\"><\/div>\n\n\n\n<div class=\"vf-grid | vf-grid__col-1\"><\/div>\n\n\n\n<div class=\"vf-grid | vf-grid__col-1\"><\/div>\n\n\n\n<div class=\"vf-grid | vf-grid__col-1\"><\/div>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":0,"parent":128,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-2177","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/2177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/comments?post=2177"}],"version-history":[{"count":4,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/2177\/revisions"}],"predecessor-version":[{"id":2191,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/2177\/revisions\/2191"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/128"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/media?parent=2177"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/embl_taxonomy?post=2177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}