{"id":128,"date":"2023-08-04T10:51:14","date_gmt":"2023-08-04T10:51:14","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/?page_id=128"},"modified":"2025-04-04T11:59:58","modified_gmt":"2025-04-04T11:59:58","slug":"research","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n
\n
\n\n

Our members define our research. The Alliance catalyzes scientific development by bringing together experts from both institutions and opening up access to new technologies.<\/p>\n\n\n\n\n\n

<\/p>\n\n\n\n

Advances in technology have paved the way for the analysis of disease and health at a global level. The challenge now lies in harnessing the wealth of information to arrive at clinically relevant insights.<\/p>\n\n\n\n

With expertise across the fields of genomics, bioinformatics, structural biology & imaging, our researchers are integrating their knowledge, to build on complementary strengths and create new research synergies.<\/a><\/p>\n\n\n\n

Projects<\/h2>\n\n<\/div>\n<\/div>\n\n\n
\n
\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
\n
\n\n

Genomics<\/h3>\n\n\n\n

Disentangling gene function & organisation in the microbiome<\/a><\/p>\n\n\n\n

Cell cycle adaptation to aneuploidy<\/a><\/p>\n\n\n\n

Mitochondrial thermal proteome profiling for the study of oncometabolites interactome<\/a><\/p>\n\n\n\n

Personalizing dilated cardiomyopathy<\/a><\/p>\n\n\n\n

Dissecting NGLY1 deficiency<\/a><\/p>\n\n\n\n

Mapping the effects of genetic variants from genes to cells to disease<\/a><\/p>\n\n\n\n

Dissecting molecular mechanisms of epigenetic silencing<\/a><\/p>\n\n\n\n

Somatic mosaicisms in cancer<\/a><\/p>\n\n\n\n

Transcription Factor cooperativity atlas<\/a><\/p>\n\n\n\n

Using scMulti-omics to probe clinical outcomes of child leukemia treatment<\/a><\/p>\n\n\n\n

Using image-assisted cell sorting to determine the molecular mechanism controlling nuclear size<\/a><\/p>\n\n\n\n

Cell-type specific chromatin loops & alternative exon usage<\/p>\n\n\n\n

Deep Learning-Powered Study of 3D Tissue Structures and Molecular Cues in Breast Cancer Initiation<\/a><\/p>\n\n\n\n

Deciphering Mechanisms and Rates of Chromosomal Instability in Gastric Cancer<\/a><\/p>\n\n\n\n

Comprehensive pharmacogenetic analysis using real world data<\/a><\/p>\n\n\n\n

Genome specialization in dinoflagellates<\/a><\/p>\n\n\n\n

Co-translational nascent chain modifications and their adaptation to cellular stress<\/a><\/p>\n\n\n\n

Unlocking the potential of image cell sorting for functional genomics and cell biology<\/a><\/p>\n\n\n\n

Dissecting gene regulatory networks driving cell type differentiation in a marine annelid<\/a><\/p>\n\n\n\n

Assessing the inter-kingdom conservation of lifespan variants evolved in yeast.<\/a><\/p>\n\n<\/div>\n<\/div>\n\n\n

\n
\n\n
<\/span>\"\"
\n

<\/p>\n<\/div><\/div>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

\n\n\n\n
\n
\n\n

Bioinformatics<\/h3>\n\n\n\n

Connecting organizational scales from the bottom-up to investigate emergence in embryonic pattern formation<\/a><\/p>\n\n\n\n

Quantifying tumour evolution and fitness landscapes<\/a><\/p>\n\n\n\n

Integrative machine learning to decipher genome function<\/a><\/p>\n\n\n\n

Non-coding RNA annotation<\/a><\/p>\n\n\n\n

Modern Statistics for Modern Biology<\/a><\/p>\n\n\n\n

Physiological regulation of metabolism in single cells<\/a><\/p>\n\n\n\n

Integrative model of human cell signalling<\/a><\/p>\n\n\n\n

Multiomics characterisation of the regulatory landscape in pulmonary arterial hypertension<\/p>\n\n\n\n

Interpretable Machine Learning for Variants in Disease<\/p>\n\n<\/div>\n<\/div>\n\n\n

\n
\n\n
\"\"<\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
\n\n\n\n
\n
\n\n

Imaging and Structural Biology<\/h3>\n\n\n\n

Integrated Structural Biology<\/a><\/p>\n\n\n\n

Networks of subcellular compartments and subcellular organization in health and disease<\/a><\/p>\n\n\n\n

Mechanism of CO2<\/sub> fixation reaction by enoyl-CoA carboxylases\/reductase<\/a><\/p>\n\n\n\n

Imaging: from electron, to light and intravital<\/p>\n\n\n\n

Watching protein\/protein- protein\/ligand-interaction dynamics within the mTOR signaling pathway resolved in time and space<\/a><\/p>\n\n<\/div>\n<\/div>\n\n\n

\n
\n\n
\"\"<\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n
\n
\n\n
\n
\n\n<\/div>\n<\/div>\n\n\n
\n
\n\n<\/div>\n<\/div>\n<\/div>\n\n<\/div>\n<\/div>\n\n\n
\n
\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-128","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/comments?post=128"}],"version-history":[{"count":39,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/128\/revisions"}],"predecessor-version":[{"id":8269,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/pages\/128\/revisions\/8269"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/media?parent=128"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/life-science-alliance\/wp-json\/wp\/v2\/embl_taxonomy?post=128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}