{"id":521,"date":"2024-03-26T12:25:30","date_gmt":"2024-03-26T12:25:30","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/infection-biology\/?page_id=521"},"modified":"2024-03-26T12:25:31","modified_gmt":"2024-03-26T12:25:31","slug":"understanding-cerebral-malaria-using-3d-blood-brain-barrier-models","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/infection-biology\/projects\/understanding-cerebral-malaria-using-3d-blood-brain-barrier-models\/","title":{"rendered":"Understanding cerebral malaria using 3D blood-brain barrier models"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Malaria is a major public health concern with more than 400,000 deaths per year. <\/h3>\n\n\n\n<p>Cerebral malaria (CM) is characterised by sequestration of infected red blood cells in the brain microvasculature, blood-brain barrier (BBB) disruption and brain swelling, resulting in high mortality. The EU-funded Mal3D-BBB project aims to model the human CM pathology with cutting-edge<em> in vitro<\/em> bioengineering approaches. My team will develop BBB models with 3D microfluidic networks that incorporate multiple cell types: brain microvascular endothelial cells, astrocytes, and pericytes. The developed platform aims to recreate physiological BBB permeability rates, and will be used to understand the molecular mechanisms of BBB disruption after <em>P. falciparum<\/em> sequestration, and whether parasite and host factors synergise to increase pathology.<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<p><strong>Maria Bernabeu<\/strong> (EMBL Barcelona)<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"536\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/erc_1200x628_96pdi-1024x536.png\" alt=\"\" class=\"wp-image-368\" srcset=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/erc_1200x628_96pdi-1024x536.png 1024w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/erc_1200x628_96pdi-300x157.png 300w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/erc_1200x628_96pdi-768x402.png 768w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/erc_1200x628_96pdi.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-521","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/comments?post=521"}],"version-history":[{"count":1,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/521\/revisions"}],"predecessor-version":[{"id":522,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/521\/revisions\/522"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/media?parent=521"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}