{"id":519,"date":"2024-03-26T12:24:07","date_gmt":"2024-03-26T12:24:07","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/infection-biology\/?page_id=519"},"modified":"2024-03-26T12:24:08","modified_gmt":"2024-03-26T12:24:08","slug":"resolving-the-unique-mechanism-of-endocytosis-of-giardia-lamblia","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/infection-biology\/projects\/resolving-the-unique-mechanism-of-endocytosis-of-giardia-lamblia\/","title":{"rendered":"Resolving the unique mechanism of endocytosis of Giardia lamblia"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\"><em>Giardia lamblia<\/em>\u00a0is an eukaryotic parasite responsible for a diarrheal condition known as giardiasis. <\/h3>\n\n\n\n<p>This disease presents challenges in drug development due to Giardia&#8217;s unique endocytosis mechanism. Contrary to previous beliefs that Giardia lacks clathrin-coated vesicles for nutrient uptake, our high-resolution cryo-electron tomography (cryo-ET) revealed the presence of vesicles resembling those found in other eukaryotes. Further, using AlphaFold2, we identified proteins capable of forming vesicle coats, indicating a more conserved vesicular trafficking system in Giardia than previously thought. This project aims to elucidate Giardia&#8217;s endocytosis mechanism, determining the role and assembly of these vesicles and their coats. By integrating time-resolved cryo-ET, structural modelling, and CRISPR\/Cas9 techniques, we plan to unlock novel therapeutic targets and strategies against Giardia, leveraging its unique endocytosis process.<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<p><strong>Jan Kosinski<\/strong> (EMBL Hamburg)<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"536\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/dfg_1200x628_96pdi-1024x536.png\" alt=\"\" class=\"wp-image-381\" srcset=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/dfg_1200x628_96pdi-1024x536.png 1024w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/dfg_1200x628_96pdi-300x157.png 300w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/dfg_1200x628_96pdi-768x402.png 768w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/dfg_1200x628_96pdi.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-519","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/comments?post=519"}],"version-history":[{"count":1,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/519\/revisions"}],"predecessor-version":[{"id":520,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/519\/revisions\/520"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/media?parent=519"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}