{"id":511,"date":"2024-03-26T12:17:43","date_gmt":"2024-03-26T12:17:43","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/infection-biology\/?page_id=511"},"modified":"2025-01-13T17:39:59","modified_gmt":"2025-01-13T17:39:59","slug":"correlative-x-ray-electron-microscopy-to-characterise-pathogenic-signatures-of-cerebral-malaria","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/infection-biology\/projects\/correlative-x-ray-electron-microscopy-to-characterise-pathogenic-signatures-of-cerebral-malaria\/","title":{"rendered":"Correlative X-ray electron microscopy to characterise pathogenic signatures of cerebral malaria"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Cerebral malaria, a severe complication of <em>Plasmodium falciparum<\/em> infection, leads to significant mortality due to brain vascular dysfunction and blood-brain barrier (BBB) alterations, culminating in vasogenic oedema and death. <\/h3>\n\n\n\n<p>The exact mechanism behind BBB dysfunction is unclear, but recent studies suggest that an exacerbated immune response, marked by CD8+ leukocyte accumulation at brain microvascular damage sites, could be crucial. This research aims to dissect the pathogenic mechanisms using correlative X-ray electron microscopy in rodent models and bioengineered 3D-microvessel systems, offering high-resolution 3D imaging to investigate leukocyte involvement and BBB structural changes. By advancing understanding of cerebral malaria pathology and exploring novel imaging technologies, the project seeks to illuminate the disease&#8217;s underlying mechanisms.<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<p><strong>Maria Bernabeu<\/strong> (EMBL), <strong>Yannick Schwab<\/strong> (EMBL), <strong>Elizabeth Duke<\/strong> (EMBL), <strong>Angelika Hoffmann<\/strong> (Inselspital Bern), <strong>Freddy Frischknecht<\/strong> (U Heidelberg)<\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"563\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2025\/01\/Maria-Synergy.jpg\" alt=\"\" class=\"wp-image-14513\" srcset=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2025\/01\/Maria-Synergy.jpg 1000w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2025\/01\/Maria-Synergy-300x169.jpg 300w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2025\/01\/Maria-Synergy-768x432.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-511","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/comments?post=511"}],"version-history":[{"count":2,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/511\/revisions"}],"predecessor-version":[{"id":14519,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/511\/revisions\/14519"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/media?parent=511"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}