{"id":504,"date":"2024-03-26T10:32:43","date_gmt":"2024-03-26T10:32:43","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/infection-biology\/?page_id=504"},"modified":"2024-03-26T10:32:44","modified_gmt":"2024-03-26T10:32:44","slug":"decoding-the-mechanisms-of-bacterial-pathogenesis-in-the-gut","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/infection-biology\/projects\/decoding-the-mechanisms-of-bacterial-pathogenesis-in-the-gut\/","title":{"rendered":"Decoding the mechanisms of bacterial pathogenesis in the gut"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">The expansion of bacterial genome datasets presents a unique opportunity to identify sequence variations associated with infections in enteric bacteria, despite the challenges of sparse phenotypic data and evolutionary differences among species. <\/h3>\n\n\n\n<p>This study aims to use phenotype-free selection scans to pinpoint hotspots for positive infection-related sequence variation in three key enteric pathogens. Employing a combination of structural prediction and co-evolution analysis to construct protein-protein interaction maps, followed by network propagation methods, the project seeks to identify and evaluate infection-relevant functional network modules and their conservation across species. Through <em>in silico<\/em> experiments and experimental validation, the research will identify critical vulnerabilities in pathogenic strains, aiming to inform infection biology and facilitate the development of new resources for the community.<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<p><strong>Evangelia Petsalaki<\/strong> (EMBL-EBI), <strong>John Lees<\/strong> (EMBL-EBI), <strong>Nassos Typas<\/strong> (EMBL), <strong>Patrick Aloy<\/strong> (IRB Barcelona)<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"536\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/network_1200x628_96pdi-1024x536.png\" alt=\"\" class=\"wp-image-386\" srcset=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/network_1200x628_96pdi-1024x536.png 1024w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/network_1200x628_96pdi-300x157.png 300w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/network_1200x628_96pdi-768x402.png 768w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/network_1200x628_96pdi.png 1200w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-504","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/504","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/comments?post=504"}],"version-history":[{"count":1,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/504\/revisions"}],"predecessor-version":[{"id":506,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/504\/revisions\/506"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/media?parent=504"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}