{"id":496,"date":"2024-03-26T10:30:06","date_gmt":"2024-03-26T10:30:06","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/infection-biology\/?page_id=496"},"modified":"2024-03-26T10:30:07","modified_gmt":"2024-03-26T10:30:07","slug":"visualising-the-membrane-proteome-of-mycoplasma-pneumoniae-and-its-role-in-infection","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/infection-biology\/projects\/visualising-the-membrane-proteome-of-mycoplasma-pneumoniae-and-its-role-in-infection\/","title":{"rendered":"Visualising the membrane proteome of Mycoplasma pneumoniae and its role in infection"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\"><em>Mycoplasma pneumoniae<\/em>, a genome-reduced pathogenic bacterium, is responsible for various respiratory diseases, yet the molecular mechanisms of its pathogenesis, particularly at the cell membrane, are not well understood. <\/h3>\n\n\n\n<p>The goal of this study is to characterise the membrane proteome of <em>Mycoplasma pneumoniae<\/em> to uncover new insights into its infection mechanisms by developing an integrated approach combining systems and structural biology. Utilising advanced technologies such as cellular cryo-electron tomography and mass spectrometry, alongside deep-learning for structure prediction, this research aims to provide a comprehensive description of <em>Mycoplasma pneumoniae<\/em>&#8216;s membrane proteins and their roles in host cell adhesion and infection.<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<p><strong>Julia Mahamid<\/strong> (EMBL), <strong>Christian L\u00f6w<\/strong> (EMBL), <strong>Juri Rappsilber<\/strong> (TU Berlin), <strong>James S\u00e1enz<\/strong> (TU Dresden)<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"682\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/IBTT_Visual_Mahaimd-1024x682.jpg\" alt=\"\" class=\"wp-image-439\" srcset=\"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/IBTT_Visual_Mahaimd-1024x682.jpg 1024w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/IBTT_Visual_Mahaimd-300x200.jpg 300w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/IBTT_Visual_Mahaimd-768x512.jpg 768w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/IBTT_Visual_Mahaimd-1536x1023.jpg 1536w, https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-content\/uploads\/2024\/02\/IBTT_Visual_Mahaimd-2048x1365.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":155,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-496","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/496","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/comments?post=496"}],"version-history":[{"count":5,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/496\/revisions"}],"predecessor-version":[{"id":503,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/496\/revisions\/503"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/pages\/155"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/media?parent=496"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/infection-biology\/wp-json\/wp\/v2\/embl_taxonomy?post=496"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}