{"id":37227,"date":"2024-03-15T12:48:59","date_gmt":"2024-03-15T12:48:59","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/?p=37227"},"modified":"2024-03-15T12:49:00","modified_gmt":"2024-03-15T12:49:00","slug":"user-story-cryo-et-to-understand-how-enteroviruses-replicate","status":"publish","type":"post","link":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/blog\/2024\/03\/user-story-cryo-et-to-understand-how-enteroviruses-replicate\/","title":{"rendered":"User story: Cryo-ET to understand how enteroviruses replicate"},"content":{"rendered":"\n<p>Marie Sorin and Bina Kumari Singh of the\u00a0<a href=\"http:\/\/www.carlsonlab.se\/research\/\">Carlson Lab<\/a>\u00a0at University of Ume\u00e5 in Sweden, spent one week at the EMBL IC performing cryo-electron tomography (cryo-ET) to study the replication process of enteroviruses, a group of viruses that includes poliovirus, coxsackievirus, and rhinovirus. This imaging technique allows scientists to visualise the structure and dynamics of these viruses at a molecular level, providing valuable insights into their replication mechanism and potential vulnerabilities for targeted therapies.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-content\/uploads\/2024\/03\/BioImaging_Users-2-1024x683.jpg\" alt=\"\" class=\"wp-image-37231\" srcset=\"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-content\/uploads\/2024\/03\/BioImaging_Users-2-1024x683.jpg 1024w, https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-content\/uploads\/2024\/03\/BioImaging_Users-2-300x200.jpg 300w, https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-content\/uploads\/2024\/03\/BioImaging_Users-2-768x512.jpg 768w, https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-content\/uploads\/2024\/03\/BioImaging_Users-2-1536x1025.jpg 1536w, https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-content\/uploads\/2024\/03\/BioImaging_Users-2-2048x1366.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"vf-figure__caption\">From left to right: Marie Sorin, Zhengyi Yang and Bina Kumari Singh examine the acquired cryo-ET data. Photo by EMBL PhotoLab\/Massimo Del Prete. <\/figcaption><\/figure>\n\n\n\n<p>Our Application Specialist, Zhengyi Yang, provided support to the users during their visit, assisting in the preparation of cryo-lamellae using FIB-milling and the acquisition of data through transmission electron microscopy (TEM) conducted under strict BioSafety Level 2 conditions.<\/p>\n\n\n\n<p>This visit was made possible thanks to the <a href=\"https:\/\/www.eurobioimaging.eu\" target=\"_blank\" rel=\"noreferrer noopener\">Euro-Bioimaging<\/a> infrastructure and funding from <a href=\"https:\/\/isidore-project.eu\" target=\"_blank\" rel=\"noreferrer noopener\">ISIDORe<\/a>. For more information, you can access the full article <a href=\"https:\/\/www.eurobioimaging.eu\/news\/cryo-et-to-understand-how-enteroviruses-replicate-\/\" target=\"_blank\" rel=\"noreferrer noopener\">here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Marie Sorin and Bina Kumari Singh of the\u00a0Carlson Lab\u00a0at University of Ume\u00e5 in Sweden, spent one week at the EMBL IC performing cryo-electron tomography (cryo-ET) to study the replication process of enteroviruses, a group of viruses that includes poliovirus, coxsackievirus, and rhinovirus. This&hellip;<\/p>\n","protected":false},"author":16,"featured_media":37229,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"embl_taxonomy":[],"class_list":["post-37227","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-general"],"acf":[],"embl_taxonomy_terms":[],"featured_image_src":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-content\/uploads\/2024\/03\/Slide1.jpeg","_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/posts\/37227","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/comments?post=37227"}],"version-history":[{"count":1,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/posts\/37227\/revisions"}],"predecessor-version":[{"id":37233,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/posts\/37227\/revisions\/37233"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/media\/37229"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/media?parent=37227"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/categories?post=37227"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/tags?post=37227"},{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/imaging-centre\/wp-json\/wp\/v2\/embl_taxonomy?post=37227"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}