{"id":632,"date":"2024-03-22T17:17:22","date_gmt":"2024-03-22T17:17:22","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/?page_id=632"},"modified":"2024-07-03T12:32:32","modified_gmt":"2024-07-03T12:32:32","slug":"epigenetics-mouse","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/projects\/epigenetics-mouse\/","title":{"rendered":"Exposure impacts on Mammalian Reproductive Fitness"},"content":{"rendered":"\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"vf-lede\">Investigating human-relevant environmental stressors relating to physical, social and biological exposures in mammals.<\/p>\n<!--\/vf-lede-->\n\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"563\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/05\/NewsVisual_HackettLab_03032023.jpg\" alt=\"\" class=\"wp-image-1476\" srcset=\"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/05\/NewsVisual_HackettLab_03032023.jpg 1000w, https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/05\/NewsVisual_HackettLab_03032023-300x169.jpg 300w, https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/05\/NewsVisual_HackettLab_03032023-768x432.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"vf-figure__caption\">Credits: Joana Carvalho\/Isabel Romero Calvo\/EMBL<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>There is an urgent need to understand how different human-relevant exposures influence reproductive tissues\/fertility. Key to this is defining if exposure responses are general or specific, the impact of contextual factors such as genetic background or age, and ultimately defining the impact on offspring. This project systematically dissects five human-relevant environmental stressors relating to physical, social and biological exposures in mammals.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Project leads<\/h3>\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"37806d1e\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=James%20Hackett&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Cemail%2Cphones%2Cmobile%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-inline -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"86364\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60023805.jpg?itok=pyP2bvrf\" alt=\"image of James Hackett\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.embl.org\/people\/person\/jamie-hackett\" class=\"vf-profile__link\">James Hackett<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Group Leader, Deputy Head of Unit (EMBL Rome)\n        <\/p>\n      \n      \n      \n              \n              \n      \n      \n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/86364\/86364\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n\n\n<p><\/p>\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"bc9065de\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=ana%20bosk&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Cemail%2Cphones%2Cmobile%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-inline -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"99556\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60035453.jpg?itok=NoEu6_U-\" alt=\"image of Ana Boskovic\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.embl.org\/people\/person\/ana-boskovic\" class=\"vf-profile__link\">Ana Boskovic<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Group Leader\n        <\/p>\n      \n      \n      \n      \n      \n      \n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/99556\/99556\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":0,"parent":161,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-632","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/632","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/comments?post=632"}],"version-history":[{"count":22,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/632\/revisions"}],"predecessor-version":[{"id":52661,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/632\/revisions\/52661"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/161"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/media?parent=632"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/embl_taxonomy?post=632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}