{"id":20353,"date":"2024-12-04T15:05:00","date_gmt":"2024-12-04T15:05:00","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/?page_id=20353"},"modified":"2026-03-09T12:02:39","modified_gmt":"2026-03-09T12:02:39","slug":"gut-germline","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/projects\/gut-germline\/","title":{"rendered":"Leveraging cohort study data to functionally interrogate human gut-germline communication"},"content":{"rendered":"\n
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This interdisciplinary project attempts to capture the first evidence of communication between the gut microbiome and the germline in humans. Work by the Hackett group and others has shed light on this \u201cgut-germline axis\u201d across phyla, with recent work in mice showing that the paternal gut microbiome can affect offspring fitness<\/a>. By combining machine learning approaches on cohort study data with in vivo<\/em> (mouse) and in vitro<\/em> (cell culture) experiments, we hope to bring novel insights into the role of the microbiome on human reproduction and its impact on the next generation.<\/p>\n\n\n\n

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Project Leads<\/h2>\n\n\n
\n \n \n
\n \"image\n \n

\n Bobby Ranjan\n <\/h3>\n \n

\n Data Scientist\n <\/p>\n \n \n \n \n \n \n \n \n Edit\n <\/a>\n <\/article>\n <\/div>\n\n\n

\n \n \n
\n \"image\n \n

\n James Hackett\n <\/h3>\n \n

\n Group Leader, Deputy Head of Unit (EMBL Rome)\n <\/p>\n \n \n \n \n \n \n \n \n Edit\n <\/a>\n <\/article>\n <\/div>\n\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":0,"parent":161,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-20353","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/20353","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/comments?post=20353"}],"version-history":[{"count":3,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/20353\/revisions"}],"predecessor-version":[{"id":80725,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/20353\/revisions\/80725"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/161"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/media?parent=20353"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/embl_taxonomy?post=20353"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}