{"id":13625,"date":"2024-10-10T08:48:34","date_gmt":"2024-10-10T08:48:34","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/?page_id=13625"},"modified":"2026-03-09T12:03:52","modified_gmt":"2026-03-09T12:03:52","slug":"protein-interactomes-associated-with-drug-resistance","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/projects\/protein-interactomes-associated-with-drug-resistance\/","title":{"rendered":"Protein interactomes associated with drug resistance"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<p class=\"vf-lede\">Combining omics and AI to decipher protein interactomes associated with the development of drug resistance.<\/p>\n<!--\/vf-lede-->\n\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-large is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"577\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/10\/omics-ai-project-visual-1024x577.jpg\" alt=\"\" class=\"wp-image-13655\" srcset=\"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/10\/omics-ai-project-visual-1024x577.jpg 1024w, https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/10\/omics-ai-project-visual-300x169.jpg 300w, https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/10\/omics-ai-project-visual-768x432.jpg 768w, https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/10\/omics-ai-project-visual-1536x865.jpg 1536w, https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-content\/uploads\/2024\/10\/omics-ai-project-visual-2048x1153.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Protein-protein interactions are crucial for translating the genome into biological traits. In drug resistance, changes in these interactions play a key role in developing resistant phenotypes. However, examining the vast range of potential interactions remains challenging, especially from an experimental perspective.<\/p>\n\n\n\n<p>This project aims to address this problem computationally by combining omics data from drug resistance studies with advanced protein structure prediction models. By using structural models to validate omics findings, we will provide a valuable resource and generate hypotheses to help further research in overcoming drug resistance.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<\/div>\n<\/div>\n\n\n<div><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\">Project leads<\/h3>\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"82be0989\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=Martin%20Garrido&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-inline -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"168493\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60039557.jpg?itok=Ne3ln1wa\" alt=\"image of Martin Garrido Rodriguez-Cordoba\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.embl.org\/people\/person\/martin-garrido\" class=\"vf-profile__link\">Martin Garrido Rodriguez-Cordoba<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Postdoctoral Fellow\n        <\/p>\n      \n      \n      \n      \n      \n      \n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/168493\/168493\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n\n\n<p><\/p>\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"58c7139a\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=Mikhail%20Savitski&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-inline -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"77840\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60008579.jpg?itok=8O2ZbX0f\" alt=\"image of Mikhail Savitski\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.embl.org\/people\/person\/mikhail-savitski\" class=\"vf-profile__link\">Mikhail Savitski<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Team Leader, Senior Scientist and Head of Proteomics Core Facility\n        <\/p>\n      \n      \n      \n      \n      \n      \n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/77840\/77840\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n\n\n<p><\/p>\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"8bb1f089\">\n      <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=Julio%20Saez&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bteam%2Cemail%2Cphones%2Cmobile%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-inline -->\n                \n                            <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--inline\" data-embl-js-conditional-edit=\"87830\">\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"https:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60011992.jpg?itok=jvxPxXf7\" alt=\"image of Julio Saez Rodriguez\" \/>\n      \n              <h3 class=\"vf-profile__title\">\n                      <a href=\"https:\/\/www.ebi.ac.uk\/people\/person\/julio-saez-rodriguez\" class=\"vf-profile__link\">Julio Saez Rodriguez<\/a>\n                  <\/h3>\n      \n              <p class=\"vf-profile__job-title\">\n          Head of Research\n        <\/p>\n      \n      \n      \n      \n      \n                                      \n            <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/87830\/87830\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":161,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-title-left-aligned.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-13625","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/13625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/comments?post=13625"}],"version-history":[{"count":3,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/13625\/revisions"}],"predecessor-version":[{"id":80729,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/13625\/revisions\/80729"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/pages\/161"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/media?parent=13625"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/human-ecosystems\/wp-json\/wp\/v2\/embl_taxonomy?post=13625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}