Timing mechanisms linking development and evolution

Time	Speaker
18:00 – 20:00	(Optional) Social programm: Local tour

Time	Speaker
08:30 – 09:30	Registration
09:30 – 09:40	Opening remarks Scientific Organisers
	Session 1: Developmental time (part 1) Session Chair: Miki Ebisuya – EMBL Barcelona, Spain
09:40 – 10:10	Keynote lecture: Understanding development and disease of the cerebral cortex: from embryos to Organoids Paola Arlotta – Harvard University, USA
10:10 – 10:40	Spatial organization through temporal dynamics in cellular communities Jordi Garcia-Ojalvo – Pompeu Fabra University, Spain
10:40 – 11:10	Timing control in gene regulatory networks: insights from T cell development Hao Yuan Kueh – University of Washington, USA
11:10 – 11:40	Coffee break
11:40 – 11:55	The regulatory mechanism behind limb heterochrony during tetrapod evolution Meng Zhu – Harvard Medical School, USA (Virtual Speaker)
11:55 – 12:10	Temporal regulation of neurogenesis Bassem Hassan- Paris Brain Institute, France
12:10 – 12:40	On the role of cell rearrangements in pattern formation Berta Verd – University of Oxford, UK
12:40 – 13:10	Using the segmentation clock to measure developmental time Olivier Pourquié – Harvard University, USA
13:10 – 14:40	Lunch break & Meet the speakers
	Session 2: Cross-species comparison Session Chair: James Briscoe – The Francis Crick Institute, UK
14:40 – 15:10	Timing and size: How a delay enables human brain enlargement Madeline Lancaster – University of Cambridge, UK
15:10 – 15:40	Timing in interspecies chimeras Jun Wu – UT Southwestern, USA
15:40 – 15:55	A stem cell zoo platform to study interspecies differences in developmental tempo Jorge Lazaro – EMBL Barcelona, Spain
15:55 – 16:10	Epigenetics-dependent temporal scaling mechanisms during brain development and evolution Quan Wu – RIKEN, Japan
16:10 – 16:40	Coffee break & Meet the speakers
16:40 – 17:10	Understanding the Hox timer by using pseudo‑embryos Denis Duboule – EPFL, Switzerland
17:10 – 17:40	Temporal regulation of signalling generates forebrain diversity Corinne Houart – King’s College London, UK
17:40 – 18:10	Flash talks Laia Caudet Segarra – Friedrich Alexander Universität Erlangen Nürnberg, Germany (Poster 43) Isabel Holguera – New York University, USA (Poster 59) Adrien Jolly – German Cancer Research Center (DKFZ), Germany (Poster 61) Hidenobu Miyazawa – EMBL Heidelberg, Germany (Poster 71) Matheo Morales – Yale University, USA (Poster 73) Alberto Rossello-Diez – Monash University, Australia (Poster 79) Shuai Sun – Max Planck Institute for Biology Tübingen, Germany (Poster 85)
18:10 – 19:40	Poster session 1 (odd numbers) with drinks & snacks

Time	Speaker
06:30 – 07:30	(Optional) Social programme: Run together
09:00 – 09:30	Registration
	Session 3: Metabolism Session Chair: Megan Davey – University of Edinburgh, UK
09:30 – 10:00	Keynote lecture: From Ontogeny to Mortality; Towards a Unified Framework of Growth, Metabolism and Lifespan Geoffrey West – Santa Fe Institute, USA
10:00 – 10:30	Keeping mitochondria in shape: a matter of life, death and differentiation Luca Scorrano – Veneto Institute of Molecular Medicine, Italy
10:30 – 11:00	Energetics of Biological Systems Jonathan Rodenfels – Max Planck Institute of Molecular Cell Biology and Genetics, Germany
11:00 – 11:30	Coffee break
11:30 – 11:45	Mitochondria-dependent metabolism regulates species-specific rates of neuronal development Ryohei Iwata – VIB-KU Leuven, Belgium
11:45 – 12:00	Mechanistic control of timescales in development Teresa Rayon – The Babraham Institute, UK
12:00 – 12:30	Timing the speed and duration of developmental processes during pancreas endocrine cell differentiation in mouse and human Anne Grapin-Botton – Max Planck Institute of Molecular Cell Biology and Genetics, Germany
12:30 – 13:00	Flexible gene expression dynamics and Drosophila development Rich Carthew – Northwestern University, USA
13:00 – 14:30	Lunch break & Meet the speakers
	Session 4: Lifespan and diapause Session Chair: Maria Robles – Ludwig Maximilian University of Munich, Germany
14:30 – 15:00	Protein turnover and longevity in mammals Sina Ghaemmaghami – University of Rochester, USA
15:00 – 15:30	Great ape organoids to explore human-specific development Grayson Camp – University of Basel, Switzerland
15:30 – 15:45	Metabolic regulation of developmental rate in mouse and human cells Margarete Diaz Cuadros – Harvard Medical School, USA
15:45 – 16:00	Evidence for a polygenic control of developmental timing in vertebrates Ali Seleit – EMBL Heidelberg, Germany
16:00 – 16:30	Coffee break & Meet the speakers
16:30 – 17:00	Metabolic enhancement of mammalian developmental pausing Aydan Bulut-Karslioglu – Max Planck Institute of Molecular Genetics, Germany
17:00 – 17:30	Cellular mechanisms of embryonic development and embryo-maternal interactions during implantation Ivan Bedzhov – Max Planck Institute of Molecular Biomedicine, Germany
17:30 – 18:00	Flash talks Natalia Benetti – Walter and Eliza Hall Institute of Medical Research, Australia (Poster 38) Megan Davey – University of Edinburgh, UK (Poster 48) Carla G. Silva – UMC Utrecht, The Netherlands (Poster 54) Girish Kale – Heidelberg University, Germany (Poster 62) Francisco Manuel Martin Zamora – Queen Mary University of London, UK (Poster 70) Victoria Mochulska – McGill University, Canada (Poster 72) Kurt Weir – Johns Hopkins School of Medicine, USA (Poster 88)
18:00 – 19:30	Poster session 2 (even numbers) with drinks & snacks
20:00 – 22:00	Conference dinner

Time	Speaker
06:30 – 07:30	(Optional) Social programme: Walk together
08:30 – 09:00	Registration
	Session 5: Developmental time (part 2) Session Chair: Pierre Vanderhaeghen – VIB KU Leuven, Belgium
09:00 – 09:30	Linking cell cycle and differentiation during development Anna Philpott – University of Cambridge, UK (Virtual Speaker)
09:30 – 10:00	Proteomics to understand circadian rhythmic physiology Maria Robles – Ludwig Maximilian University of Munich, Germany
10:00 – 10:30	Entwining space and time in the developing brain Denis Jabaudon – University of Geneva, Switzerland
10:30 – 11:00	Coffee break & Meet the speakers
11:00 – 11:15	Cell mechanics influences the mammalian circadian clock via YAP/TAZ Juan F. Abenza – Institute for Bioengineering of Catalonia/CIBER-BBN, Spain
11:15 – 11:30	Human-specific progenitors contribute to expanded timescales and output of motor neurogenesis Sumin Jang – Columbia University, USA
11:30 – 12:00	Setting timescales for epigenetic switching Martin Howard – John Innes Centre, UK
12:00 – 12:30	A human-specific modifier of cortical circuit connectivity and function improves behavior performance Franck Polleux – Columbia University, USA
12:30 – 13:00	Awards & Concluding remarks Scientific Organisers

EMBL Barcelona is located at the Barcelona Biomedical Research Park (PRBB). The PRBB is located on Barceloneta seafront between Hospital del Mar and the Arts Hotel in the Olympic Port of Barcelona.

Address: Barcelona Biomedical Research Park, C/ Doctor Aiguader, 88, 08003 Barcelona

The conference is taking place in the PRBB auditorium. It is located on a raised level, in the heart of the PRBB building overlooking the sea, with independent access from the rest of the building. Access to the Auditorium will be by the stairs located at the entrance of the inner square of the building. For people with limited mobility, the access through lifts up the 1st floor can be used.

While on campus, please wear your conference badge at all times for security purposes.

Accommodation is not included in the conference registration fee.

Below is a list of hotels that are located near the conference venue.

Please note that a city tax per person/per night for the stay needs to be paid (whether you book in a hotel or through Airbnb).

Hotel Name	Address	Bookings
H10 Marina	Avinguda del Bogatell, 64-68 Olympic Village, 08005 Barcelona (map | website)	Tel. +34 933 09 79 17 corporate.hmb@h10hotels.com grupos.hmb@h10hotels.com
H10 Port Vell	Pas de Sota Muralla, 9, 08003 Barcelona (map | website)	Tel. +34 933 10 30 65 reservas.hpv@h10hotels.com
Hotel SB Icaria:	Av. d’Icària, 195, 08005 Barcelona (map | website)	Tel. +34 932 21 82 00 reservations.icaria@sbhotels.es
Hotel Ibis Styles:	Carrer de Llull, 71, 08005 Hb004742, Barcelona (map | website)	Tel. +34 934 83 37 48 H9663@accor.com
RESA – campus del Mar Residencia	Pg. Salvat Papasseit, 4 08003 Barcelona (map| website)	Tel. +34 933 90 40 00 campusdelmar@resa.es
RESA – La Ciutadella Residencia	Passeig Pujades, 33-37 08018 Barcelona (map| website)	Tel. +34 933 94 32 00 ciutadella@resa.es

Catering

Lunches and coffee breaks are included in the registration fee. The lunch buffets and coffee breaks will be set-up in front of the Auditorium. Snacks will be served on the first evening of the workshop during the Welcome reception (PRBB terrace), as well as during the poster sessions (groundfloor beneath the Auditorium). 

Dinners are at the participants own expense unless otherwise specified.  

Please wear your badge at all times when serving yourself.

No food or drinks are allowed in the PRBB auditorium.

Electricity and charging station

The mains voltage in Barcelona is 230 volts AC. The flat European standard and the Schuko plug CEE 7/7 fit into the Spanish sockets. Most Europeans do not need to buy an adapter plug for Spain. Please note that there are no power outlets in the auditorium. You can recharge your electronic devices at the reception area. We kindly ask you to bring your own charger cables. The charging station will be left unattended.           

Health and safety notes

Please read Barcelona’s COVID-19 terms and conditions for events.
Smoking is prohibited in all PRBB facilities
Eating and drinking is prohibited in the Auditorium.
Do not enter any restricted areas or the laboratories unless authorised to do so.Do not enter any restricted areas or the laboratories unless instructed to do so.

If first aid is required …

• Assist the casualty and provide first aid if trained to do so. 
• Take to Hospital del Mar, Pg Maritim Barceloneta, 23*31 OR
• Dial the emergency number 1020 from any internal phone OR
• Dial 112
• Please report all accidents to the Conference Officer at the Registration Desk.

In case of fire …

• Press the nearest fire alarm button or dial the emergency number 1020 from any internal phone.
• There will be a loudspeaker announcement (in Catalan, Spanish, English) if an evacuation is required. 
• On hearing the evacuation message leave the building promptly following the escape route and exit signs and proceed to the meeting point (“Punto the reunion”) on Passeig Maritim Barceloneta next to the sea side.

Beyond first aid…

Please remember to bring your own medication, if needed, to the conference.

Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor.

Internet

It is easy to access the internet via a wireless connection in any area of the building. When connecting a mobile device, the operating system automatically recognises the network “PRBB”. The passport for this network is “darwin1809”.

The PRBB also participates in the Eduroam project, which aims to allow network access for visitors from academic institutions associated with Eduroam. Access to the service is always delivered with the same credentials as in the home institution.

Lost and found

“Lost and Found” items are kept at Registration and will be stored at the EMBL Barcelona reception for a short whileafter the EMBO workshop.

Luggage

There are no lockers available on-site to store your belongings. It is highly recommended to leave any valuables in your accommodation. An unguarded wardrobe area is behind the registration desk. You may use this wardrobe at the last day of the Workshop to store your luggage. 

The venue is directly located at the beachside. Be aware of your surroundings and belongings when leaving the building. 

Phone numbers

In case of emergency, contact Security on the ground floor: 

Ext. 1020 / 0034933160020 

Reception: Ext. 1000 or 0034933160000

Below are the most important emergency service phone numbers for Barcelona. 

Fire service: 080

Medical emergencies: 061

Police (Mossos d’Esquadra): 088

The Mossos d’Esquadra are Catalonia’s autonomous community police force. They are responsible for crime investigations, crime prevention and assistance at accident scenes. 

Guàrdia Urbana: 092 

The Guàrdia Urbana are responsible for public order by patrollling the roads and streets. They also look after traffic safety and control. The Guardia Urbana are also the first point of call for everyday situations such as neighbourhood disputes like noise etc.

All general emergencies: 112

If you become ill during the event, please notify the Conference Officer(s) immediately.  

Photography

During the conference an EMBL Photographer may be taking photographs. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.

Pickpockets

It is highly recommended to leave any valuables in your accommodation. The venue is located at the beachside which is a very busy area. Be aware of your surroundings and belongings when leaving the building.

Sightseeing

A variety of activities in Barcelona can be found in this website: https://www.barcelona-tourist-guide.com/

Time

Spain operates on Central European time (CET), which means that the country is 6 hours ahead of eastern standard time (EST) in the United States and 1 hour ahead of Greenwich mean time (GMT).

Travel to and from the venue

Our EMBO Workshop partner hotel, the “H10 Marina”, is a 15 minutes walk to the venue. 

If you prefer, you can also take the bus. The next bus stop is in 6 minutes walking distance to the hotel. Line V27 is departing from Av Icària – Joan Miró to Pg Marítim – Hospital del Mar. From there it is another 3 minute walk. 

Additionally, a taxi stand is located just outside the hotel main entrance.

Hotel address: Avinguda del Bogatell, 64-68 Olympic Village, 08005 Barcelona

Useful Spanish expressions

English	Spanish
Hello	Hola
Good morningGood afternoonGood eveningGood night	Buenos díasBuenas tardesBuenas nochesBuenas noches
I’m sorry	Lo siento / Perdona
Excuse me…	Perdóneme…
How are you?	¿Cómo estás?
I’m fine thanks. And you?	Estoy bien, gracias. ¿Y usted?
What is your name	Cómo te llamas
My name is	Me llamo
Do you speak English	Habla usted Inglés
I don’t understand	No entiendo
Please speak more slowly	Por favor hable más despacio
Thank you	Gracias
Where is the toilet?	¿Dónde está el servicio?
Please call me a taxi	Puedes avisar/llamar un taxi, por favor?
How do I get to….?	Como llego a….?
A beer/two beers please	Una cerveza / dos cervezas por favor.
A glass of red/white wine please	Un vaso de vino tinto / blanco por favor.
The menu, please	El menú, por favor
Is there a local speciality?	¿Hay alguna especialidad local?
I’m Vegetarian	Soy vegetarianoa
It was delicious	Estaba delicioso
The bill, please	La cuenta, por favor
I have a headache	Me duele la cabeza
I have a sore throat	Tengo dolor de garganta
My stomach hurts	Me duele el estómago
I’m allergic to	Soy alérgico a
I need a doctor who speaks English	Necesito un médico que hable inglés

Getting to Barcelona – By Plane

Barcelona-El Prat airport is located in El Prat de Llobregat just 12 km South West of the Barcelona city centre. It has two passenger terminals: Terminal 1 (T1) and Terminal 2 (T2). The airport has allocated airlines to terminals, regardless of the destination of the flight.

Airport Transfers to the city centre

The Aerobús is an express bus service that connects the Barcelona-El Prat airport with the city centre (Plaça Catalunya) in 35 minutes. You can take the Aerobús outside Terminal 1 (A1) and Terminal 2 (A2). This service runs every day of the year with departures between 5 and 15 minutes. From the city centre, you can take the metro or a bus to move around Barcelona.

The train service (R2 line) runs approximately every 30 minutes to and from Barcelona airport to the city centre. The journey takes 25 minutes. The train service operates from Terminal 2 (T2). To get from T2 to T1, use the shuttle bus service (Bus transit T1-T2). If you travel from the airport to the city centre, you can get off at Barcelona-Sants, Passeig de Gràcia or Clot which are serviced by metro stops.

You can also take the metro line L9 (orange) from the airport. It departs at Terminal 1 and connects at stations Torrassa (L1 and L10 Sud), Collblanc (L5 and L10 Sud) with metros to the city centre. 

You will find a taxi rank outside any of the main terminal exits. Look for the sign pointing to the nearest taxi rank. All official Barcelona taxis are black and yellow and are required to charge you only the value on the taximeter (plus any surcharge, e.g. luggage or night). The rates and surcharges are displayed inside the cab. In Barcelona, a taxi may be either ordered by phone, found at authorised taxi rank or flagged down in the street.            

Getting to Barcelona – By train

Barcelona Sants is the main train station for national and international arrivals and departures in Barcelona. It is situated in plaça dels Països Catalanes – Barcelona. National and regional trains also depart from França station. It is located at avinguda Marquès de l’Argentera, s/n – Barcelona.

Spanish Railways (RENFE)

Public Transport in Barcelona

Metro and tram

The metro network of Barcelona is very good and the trains are frequent and quick. You do not have to worry about timetables. Almost all attractions are within walking distance of a metro or tram station. When there are no subways, the gap can be filled by tram.

You can find the operating hours of the metro and tram here.

Buses

The operating times of the buses are different for each line. You will find a notice board with the timetable at each stop. They operate from about 5:00 clock to about 22:00 clock.

Night bus (NitBus)

Both the metro and the buses do not run all night. In Barcelona, there is a fairly dense network of night buses to get you back to your hotel all night long. Except for the line N0 all lines stop at Plaça Catalunya and can change there. The N0 line is a circular line that allows you to circle around the city center and change to the other NitBus. The night buses are operated by the private operator AMB, which is why the Barcelona Card and Hola BCN Ticket are not valid.

The N17 line goes to the airport.

The operating hours of the NitBus are different for each line, but they run from about 22:00 to 05:00 clock.

What do I need to bring in order to access the conference?

1. Negative antigen / PCR COVID-19 test, not older than 24h for antigen and 72h for PCR tests OR valid proof of vaccination (Vaccines authorized by EU or WHO) by the event’s date OR valid proof of recovery (accreditation that you have passed COVID less than 6 months before the event) 
2. Your ID document/passport
3. A medicinal mask, either surgical or FFP2 

What kind of masks must be worn onsite?

A medicinal mask, either surgical or FFP2 (the latter is recommended) to be worn at all times indoors, except when eating or drinking and especially when in the auditorium or at the registration desk.

Do I need to wear a mask outside of the conference venue?

Masks must be worn in the following areas:

• Public and passenger transport. On platforms and stations, it is not necessary to carry it.
• Hospitals, health centers and pharmacies.
• Residences (workers and visitors).
• It is also recommended that people with a positive diagnosis of covid-19 or with compatible symptoms and vulnerable people who are unable to maintain a minimum safety distance.

For more information please check: https://web.gencat.cat/ca/activem/restriccions-territorials/catalunya/#bloc1

Which COVID-19 vaccines are recognised in Spain?

Any vaccine authorised by theEuropean Union (European Medicines Agency, EMA) and WHO will be accepted. Certificates with vaccines not authorised by these agencies are also acceptable, but the last dose administered must be of one of the authorised vaccines. 

Complete vaccination schedules are defined as those established in the COVID-19 Vaccination Strategy in Spain.

What is the validity of vaccination proof in Spain?

From 1 February 2022, proof of vaccination is valid from 14 days after the date of administration of the last dose of the complete vaccination schedule and will be valid up to 270 days from the date of administration of that last dose.

Thereafter, in order to be valid, the vaccination certificate must reflect the administration of a booster dose. These certificates will be considered valid since the day the booster dose was administered.

What is the validity of proof of recovery in Spain?

Certificate of Recovery: corresponds to a test no more than 180 days after the date of the first positive NAAT test result and no earlier than the 11th day following the date of that positive test result. The certificate must state the date of the first positive test.

Do I need to register and quarantine when arriving in Spain?

You can find the latest information on entry and entry requirements for Spain on the Spain Travel Health Website. Please make sure to carefully read the information and to comply with all requirements and to carry the necessary supporting documentation.

Where can I get tested for COVID-19 in Barcelona and how much does it cost?

An antigen rapid test costs approximately 35-45€, a PCR test approximately 85-100€. You can also find more information about the different tests and links to some test centres here.

Costs of the test must be covered by the participants.

What if I test positive during the event?

If during the conference you test positive or develop symptoms associated with COVID-19, such as reduced sense of smell and taste, chills, sore throat, muscle aches, headache, general weakness, diarrhea or vomiting, you should:

1. Refrain from coming to the event, or leave promptly
2. Contact the health service: contact the corresponding health authorities of the Autonomous Communities by telephone. If you feeling that the illness is serious, you have shortness of breath or chest pain, call 112
3. Call 933 038 158, where they will also assist you in English

What are the current local restrictions (e.g. public transport, restaurants or cafes)? Where can I find more information?

Specific rules and restrictions for Catalonia can be found here: https://web.gencat.cat/ca/activem/restriccions-territorials/catalunya/#bloc1  

Further information is also available via: https://spth.gob.es/faq?tab=2