Introduction to SBX and advanced NGS for genomic research

Overview

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Course overview

This course provides an in-depth introduction to our breakthrough DNA sequencing technology,
Sequencing by Expansion (SBX). Participants will gain a comprehensive understanding of how SBX
works and its advantages in terms of speed, accuracy, and efficiency.
In addition to SBX, the course will cover our advanced NGS library preparation solutions, including
KAPA, offering insights into best practices for high-quality library prep.
Beyond the technical aspects, participants will explore key applications of these technologies in
cutting-edge genomic research and clinical diagnostics. Topics include early cancer detection,
comprehensive genomic profiling (CGP) for precision oncology, and minimal residual disease (MRD)
monitoring for improved patient outcomes.
Through expert-led presentations and interactive discussions, attendees will gain valuable knowledge
on the latest innovations in sequencing and their impact on healthcare and research.

Audience

This course is designed for researchers, clinicians, and bioinformaticians working in genomics,
molecular biology, and precision medicine. It is particularly relevant for scientists and lab professionals
with experience in next-generation sequencing (NGS), as well as those looking to expand their
expertise in emerging sequencing technologies like Sequencing by Expansion (SBX). Participants
may include doctoral students, postdoctoral researchers, principal investigators, laboratory
technicians, and industry professionals involved in genomic research, oncology, and translational
medicine.
Attendees should have a basic understanding of DNA sequencing and NGS workflows, though no
prior experience with SBX is required. The course will help them refine their sequencing strategies,
optimize workflows, and apply advanced techniques for cancer detection, comprehensive genomic
profiling (CGP), and minimal residual disease (MRD) monitoring. This training is ideal for those aiming
to enhance their research capabilities, implement cutting-edge sequencing methods, and contribute to
advancements in genomics and precision medicine.

Modules/resources

Introduction to Sequencing by Expansion (SBX)
● Overview of SBX technology
● Key advantages: speed, accuracy, efficiency
● Comparison with traditional sequencing methods

NGS Library Preparation Solutions
● Introduction to KAPA library prep
● Best practices for high-quality library preparation
● Optimizing workflows for different applications

Key Applications in Genomic Research & Clinical Diagnostics
● Early Cancer Detection
-Role of sequencing in detecting cancer at early stages
-Benefits of liquid biopsy and ctDNA analysis
● Comprehensive Genomic Profiling (CGP)
-How CGP enables precision oncology
-Identifying actionable mutations for targeted therapies
● Minimal Residual Disease (MRD) Monitoring
-Importance of MRD detection in treatment response
-Applications in hematologic malignancies and solid tumors

Hands-on Training and Case Studies
● Real-world examples of SBX in research and clinical settings
● Best practices for data interpretation
● Troubleshooting and optimizing sequencing workflows

Learning outcomes

By the end of the course, participants will be able to:

● Understand Sequencing by Expansion (SBX)
-Explain the principles and advantages of SBX technology
-Compare SBX with traditional sequencing methods

● Master NGS Library Preparation Techniques
-Gain hands-on experience with KAPA library preparation
-Apply best practices for high-quality sequencing data generation

● Explore Key Applications in Genomics & Medicine
-Understand the role of sequencing in early cancer detection
-Analyze comprehensive genomic profiling (CGP) for precision medicine
-Apply sequencing methods for minimal residual disease (MRD) monitoring

● Enhance Practical and Analytical Skills
-Troubleshoot common sequencing challenges
-Interpret sequencing data effectively for research and clinical applications

● Integrate Advanced Sequencing Techniques into Research
-Optimize sequencing workflows for various applications
-Implement SBX and advanced NGS solutions in laboratory and clinical settings

● Network and Collaborate with Experts
-Engage with leading scientists and industry professionals in genomics
-Discuss emerging trends and future directions in sequencing technology

Sponsors

Sponsorship opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.