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The Mobile Genome: Genetic and Physiological Impacts of Transposable Elements – Course and Conference Office

EMBO Workshop

The Mobile Genome: Genetic and Physiological Impacts of Transposable Elements

Overview

Places are still available, follow this link to register. Abstract submissions for oral and poster presentations are, however, no longer possible.

EMBL is committed to sharing research advances and sustaining scientific interaction throughout the coronavirus pandemic. We are delighted to announce that this conference is going virtual and invite you to join us online.

Conference Overview

This conference is assembling world-leading experts from diverse fields including genomics, epigenetics, structural biology, developmental biology, immunology, cancer biology and neurobiology, to discuss the broad impacts of TEs on organismal biology.

This conference provides a venue for cross-disciplinary discussions, with the goal of catalysing inter-disciplinary collaborations to address emerging questions in these scientific fields.

Although often disparaged as “junk” DNA, it is now undeniable that transposable element (TE) activity has significantly shaped the structure and function of all genomes, ranging from bacteria to humans. TEs are major drivers of genetic diversity and contribute to human disease. Remarkably, recent research has shown that TE-derived sequences also can be co-opted by the host to play important roles in gene expression, early development, immunity, neuronal diversification, and, perhaps, aging.

Session Topics

  • Genomics and evolution
  • Transposon regulation
  • Transposition mechanisms
  • Physiological impacts

Speakers

Keynote Speakers

Speakers

Vincent Colot

Institut de Biologie, École Normale Supérieure

France

Fred Dyda

National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health

USA

Frank M.J. Jacobs

Swammerdam Institute for Life Sciences, University of Amsterdam

The Netherlands

Steve Jacobsen

University of California, Los Angeles, Howard Hughes Medical Institute

USA

Pascale Lesage

Inserm, CNRS, Université Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis

France

Didier Trono

École Polytechnique Fédérale de Lausanne

Switzerland

Jernej Ule

University College London Queen Square Institute of Neurology

UK

Scientific Organisers

Conference Organisers

Lisa Trinh

EMBL Heidelberg

Germany

Diah Yulianti

EMBL Heidelberg

Germany

Programme

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  • The virtual conference includes live-streamed keynote lectures, invited speakers talks and selected short talks and flash talks.
  • All digital poster presenters are encouraged to upload a recorded flash talk or narration with their digital poster.
  • Information on the live stream and access to the discussion platform and digital posters will be provided 1 week before the start of the event.
  • Access to the recorded talks will be available until 15 September 2021.
  • All times in the programme below are shown as the time in Europe/Berlin.

To find out the equivalent time zone in your location, enter Berlin, the programme time and date along with your city into the Time Zone Converter.

Day 1 – Sunday, 29 August 2021
Time
(Europe/Berlin)
Speaker
14:00-14:10Opening remarks
AVAILABLE ON DEMAND AFTER LIVE STREAM
Session 1 – Genomics and evolution (part 1)
Chairs: John Moran and Sandra Richardson
14:10-14:40Transposable elements as catalysts of regulatory evolution
Cedric Feschotte – Cornell University, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
14:40-15:00Genome evolution and the control of transposable elements during germline development in Drosophila
Felipe Karam Teixeira – University of Cambridge, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:00-15:30Evolution of commensal Escherichia coli strains in the mouse gut
Isabel Gordo – Fundação Calouste Gulbenkian, Portugal
15:30-15:45Break
15:45-16:15Insights from CLIP on protein-RNA interactions at sequences derived from transposable elements
Jernej Ule – University College London Queen Square Institute of Neurology, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:15-16:35Novel clades of Penelope-like retrotransposable elements enlarge the genomes of aquatic plants and animals
Irina Arkhipova – Marine Biological Laboratory, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:35-17:05Two GTSF paralogs implicated in piRNA biogenesis in Bombyx mori
René Ketting – Institute of Molecular Biology, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:05-17:35MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO
Steve Jacobsen – University of California, Los Angeles, Howard Hughes Medical Institute, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:35-17:50Poster flash talk presentations 1 by:
1. Constance Ciaudo, ETH Zurich, Switzerland
2. Juliane Glaser, Max Planck Institute for Molecular Genetics, Germany
3. Ophélie d’Udekem, UCLouvain, Belgium
4. Christopher Grochowski, Baylor College of Medicine, USA
17:50-18:20Meet the speakers session 1 (part 1) with:
Cedric Feschotte, Isabel Gordo, Jernej Ule, René Ketting, Steve Jacobsen, Felipe Karam Teixeira and Irina Arkhipova
18:20-18:35Break
18:35-19:35Informal topic discussion in breakout rooms on the following topics:

1. How emerging sequencing technologies can inform us on transposable element biology.
With Sandra Richardson, Francisco Sanchez and John Moran

2. How genome defense systems impact evolution of gene expression systems.
With Hiten Madhani, Mia Levine, Alex Bortvin, Astrid Haase and Julius Brennecke

3. The impact of sequence-based and structural methods in advancing mechanistic mobile DNA biology.
With Liz Kellogg, Gera Smyshlyaev, Joe Peters, Cedric Feschotte (TBC) and Orsolya Barabas

4. Novel approaches to uncover the impact of Transposable Elements
With Helen Rowe, Sara R Heras, Julianne Glaser, Manvendra Singh and Jose Luis Garcia-Perez
19:35-20:35Poster session 1
(live chats and video calls with poster presenters with last names A-F)
Day 2 – Monday, 30 August 2021
Time
(Europe/Berlin)
Speaker
13:00-13:45Social programme: speed networking
Session 1 – Genomics and evolution (part 2)
Chairs: John Moran and Sandra Richardson
14:00-14:30Transposable elements contribute to gene expression variation in Drosophila melanogaster immune-stress response
Josefa González – Institute of Evolutionary Biology, CSIC-UPF, Spain
AVAILABLE ON DEMAND AFTER LIVE STREAM
14:30-14:50H3k9 and h3k27 methylations are differently regulated by polycomb-associated proteins and have distinct functions in programmed genome rearrangement of tetrahymena
Kazufumi Mochizuki – Institut de Génétique Humaine, CNRS, France
AVAILABLE ON DEMAND AFTER LIVE STREAM
14:50-15:20TE mobilization: A major and tunable source of heritable variation in Arabidopsis thaliana
Vincent Colot – Institut de Biologie, École Normale Supérieure, France
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:20-15:35Break
15:35-16:05Transposable elements, their polydactyl controllers and the ups and downs of human speciation
Didier Trono – École Polytechnique Fédérale de Lausanne, Switzerland
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:05-16:25Transposons co-option in the Caenorhabditis germline regulatory network
Francesco Nicola Carelli – University of Cambridge, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:25-16:40Poster flash talk presentations 2 by:
1. Astrid Haase, National Institute of Diabetes and Digestive and Kidney Diseases, USA
2. Vivien Horvath, Stem Cell Center, Lund University, Sweden
3. Elizabeth Kellogg, Cornell University, USA
4. Henry Levin, National Institutes of Health, USA
16:40-17:10Meet the speakers session 1 (part 2) with:
Josefa González, Vincent Colot, Didier Trono, Kazufumi Mochizuki and Francesco Nicola Carelli
17:10-18:10Poster session 2
(live chats and video calls with poster presenters with last names G-L)
Session 2 – Transposon regulation (part 1)
Chairs: Julius Brennecke and Astrid Haase
18:10-19:00Keynote: Marking retrotransposons, from DNA to RNA methylation
Déborah Bourc’his – Institut Curie, France
AVAILABLE ON DEMAND AFTER LIVE STREAM
19:00-19:30Evolution of scrambled genome architectures
Laura Landweber – Columbia University, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
19:30-19:50Structure of a restriction factor of the S. cerevisiae transposon Ty1 reveals the molecular basis of transposition copy number control
Sean Beckwith – University of Georgia, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
19:50-20:05Break
20:05-20:35Intra-genomic conflict shapes Drosophila telomere biology
Mia Levine – University of Pennsylvania, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
20:35-20:55Analysis of intercellular transmission of retrotransposons in drosophila melanogaster ovaries
Marianne Yoth – iGReD, France
AVAILABLE ON DEMAND AFTER LIVE STREAM
20:55-21:25Epigenetic evolution over geological timescales
Hiten Madhani – University of California, San Francisco, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
21:25-22:00Meet the speakers session 2 (part 1) with:
Déborah Bourc’his, Laura Landweber, Mia Levine, Hiten Madhani, Sean Beckwith and Marianne Yoth
Day 3 – Tuesday, 31 August 2021
Time
(Europe/Berlin)
Speaker
Session 2 – Transposon regulation (part 2)
Chairs: Julius Brennecke and Astrid Haase
14:00-14:30SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation
Ansgar Zoch – The University of Edinburgh, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
14:30-14:50Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation
Sophia Groh – Ludwig Maximilians University of Munich, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
14:50-15:10The nuclear endoribonuclease SLFN9 enforces retrotransposon silencing
Mathilde Gauchier – National Institutes of Health, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:10-15:25Break
15:25-15:55Transposable element biology: Expression and integration in the host genome
Séverine Chambeyron – Institut de Génétique Humaine, CNRS, Université de Montpellier, France
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:55-16:10Poster flash talk presentations 3 by:
1. Derek Rookhuizen, Insitut Curie, France
2. Miriam Merenciano, Institute of Evolutionary Biology (CSIC-UPF), Spain
3. Irma Querques, University of Zurich, Switzerland
4. Wayo Matsushima, École Polytechnique Fédérale de Lausanne, Switzerland
16:10-16:40Meet the speakers session 2 (part 2) with:
Ansgar Zoch, Séverine Chambeyron, Sophia Groh and Mathilde Gauchier
16:40-17:25Panel discussion on provocative emerging research areas on Mobile DNA

Panel members:
Deborah Bourc’his
Josefa Gonzalez
David Schatz
Oliver Weichenrieder
17:25-18:25Poster session 3
(live chats and video calls with poster presenters with last names M-R)
Session 3 – Transposition mechanisms (part 1)
Chairs: Orsolya Barabas and Joseph Peters
18:25-19:15Keynote lecture: A structural journey through the evolution of the RAG transposase/recombinase
David Schatz – Yale School of Medicine, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
19:15-19:45Control of Ty1 retrotransposition from transcription to integration
Pascale Lesage – Inserm, CNRS, Université Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis, France
AVAILABLE ON DEMAND AFTER LIVE STREAM
19:45-20:05Structural basis for DNA targeting by the Tn7 transposon
Alba Guarne – McGill University, Canada
AVAILABLE ON DEMAND AFTER LIVE STREAM
20:05-20:20Break
20:20-20:40Cryo-EM studies of an antibiotic resistance gene carrying transposon: Insights into the excision of GIsul2
Buse Isbilir – EMBL Heidelberg, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
20:40-21:10Three domains, two catalytic Tyrosines and an active monomer: The Cryo-EM structure of a Helitron transposase
Fred Dyda – National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
21:10-21:40Meet the speakers session 3 (part 1) with:
David Schatz, Pascale Lesage, Fred Dyda, Alba Guarne and Buse Isbilir
21:40-22:10Live Living room concert with Lazy Fur
22:10-22:40Social programme: bar mixer
Day 4 – Wednesday, 1 September 2021
Time
(Europe/Berlin)
Speaker
13:00-13:45Meet the editors session with:
Esther Schnapp – EMBO Reports
Carolina Perdigoto – Nature Structural & Molecular Biology
Session 3 – Transposition mechanisms (part 2)
Chairs: Orsolya Barabas and Joseph Peters
14:00-14:30Human LINE-1 DNA methylation is cell-type-, family- and locus-specific and is not predictive of expression
Gael Cristofari – Inserm, CNRS, Université Côte d’Azur, France
AVAILABLE ON DEMAND AFTER LIVE STREAM
14:30-14:50Identification of an integrase-independent pathway of retrotransposition
Feng Li – National Institutes of Health, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
14:50-15:20Bacterial group II intron retrotransposons: Diversity is the keyword
Maria Costa – CNRS, France
15:20-15:35Poster flash talk presentations 4 by:
1. Sandra Duharcourt, Institut Jacques Monod/CNRS, France
2. Emilia Skirmuntt, University of Oxford, UK
3. Oliver Weichenrieder, Max Planck Institute for Developmental Biology, Germany
4. Manvendra Singh, Cornell University, USA
15:35-16:05Meet the speakers session 3 (part 2) with:
Gael Cristofari, Maria Costa and Feng Li
16:05-17:05Poster session 4
(live chats and video calls with poster presenters with last names S-Z)
Session 4 – Physiological impacts
Chairs: Jose L. Garcia-Perez and Juliane Glaser
17:05-17:35Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration
Samuel Sternberg – Columbia University, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:35-17:55Somatic LINE retrotransposition in motorneurons
Thomas Widmann – GENYO – Centre for Genomics and Oncological Research, Spain
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:55-18:25Epigenetic regulation of LINE-1 elements by the HUSH complex and physiological impacts
Helen Rowe – Queen Mary University of London, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
18:25-18:40Break
18:40-19:10Structural variation in transposable elements as hidden genetic modifiers in human disease-risk loci
Frank Jacobs – Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
19:10-19:30RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability
Ruoyu Wang – The University of Texas Health Science Center at Houston, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
19:30-20:00Co-opted functions of transposble-derived sequences in humans
Zsuzsanna Izsvak – Max Delbrück Center for Molecular Medicine, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
20:00-20:15Break
20:15-20:45LINE-1 in cancer biology
Kathleen Burns – Dana-Farber Cancer Institute, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
20:45-21:05PGBD5 DNA transposase induces DNA damage in the brain and is required for its normal development
Luz Jubierre Zapater – Memorial Sloan Kettering Cancer Center, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
21:05-21:35Evolutionary landscapes in host-virus arms races
Harmit Malik – Fred Hutchinson Cancer Research Center, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
21:35-21:45Closing remarks
AVAILABLE ON DEMAND AFTER LIVE STREAM
21:45-22:15Meet the speakers session 4 with:
Samuel Sternberg, Helen Rowe, Frank Jacobs, Zsuzsanna Izsvak, Kathleen Burns, Harmit Malik, Thomas Widmann, Ruoyu Wang and Luz Jubierre Zapater

Practical information

Registration Fees and Abstract Submission

Registration Fees (include access to all of the talks, online group discussions, and help us cover our costs to run the event):

Academia190 Euro
PhD Student140 Euro
Industry240 Euro
EMBL StaffIntranet access

Accredited journalists may be eligible to register for a reduced press rate or in some cases for complimentary registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Lisa Trinh for more information.

Confirmation and Payment

Registration will be on a first-come first-served basis. Your place can only be confirmed after payment of the registration fee.
Types of payments accepted are international bank transfers (only up to 8 weeks before event) and credit card payments.

Abstract submission

Only registered participants are eligible to submit an abstract. We only accept online abstract submissions. 

After registration you can submit your abstract via a separate link that will be provided in the email confirmation. Alternatively, you can access the link on the confirmation page directly after registering. The same login credentials are used for both processes.

Please note:

Title: The title should not exceed 20 words. Only the first word of the title should start with a capital letter and the rest of the title should be in lowercase.

Authors and Affiliations: Please fill in the author’s details as requested in the online form. The compulsory details are: First Name, Last Name, Organisation Name (Affiliation or Company), Country and Email. Mark only one author as the role of First author and please don’t forget to indicate who will be presenting. The order of the authors will be listed as follows: First Author, Co-First Author (alphabetically if multiple), co-author(s) (in the order added by the submitter).

Presentation Types: When submitting your abstract, you can apply for an oral or poster presentation. A selection process will take place with the results announced 2-3 weeks after the abstract submission deadline.

Please check our FAQs pages for further information on how to submit an abstract.

Financial Assistance

Registration Fee Waivers

All academic and student registrants are invited to apply for a registration fee waiver, provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO. The registration fee waiver covers the registration sum that you have paid to attend the meeting. Conference participants are not required to pre-pay the registration fee to be selected for a fee waiver for a virtual meeting. If you have already paid the registration fee and are awarded a fee waiver, it will be reimbursed after the meeting. Course participants are required to pay the course fee in advance, which will then be reimbursed after the recipient has attended the course.

Childcare Grants

For participants and speakers with childcare responsibilities there is the possibility to apply for a grant, provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO, to offset childcare costs incurred when participating at a virtual event. Eligible costs include fees for a babysitter or childcare facility or travel costs for a care giver. Please note that priority will be given to early stage researchers. Costs will be reimbursed after the meeting only once a reimbursement form and original receipts have been received. Attendance at the event is required in order to be eligible to receive the reimbursement. In order to apply for this grant, you must be registered by the abstract submission deadline.

Boehringer Ingelheim Fonds Travel Grant

Applies to selected courses only. Availability will be indicated during the abstract or motivation letter submission process.

This grant covers costs related to your attendance to the course (registration, travel and accommodation costs). The grant is restricted to PhD students and postdocs who conduct basic biomedical research.
Whether you are eligible to apply for a travel grant, depends on when you received your university entrance qualification (e.g. Abitur, A-Levels, High School Diploma, Final State Examination):

– for PhD and MD students, as well as graduates, the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course
– for postdocs, the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course

Application

Applications for financial assistance can be submitted via the submission portal* (for the submission of abstracts for conferences or the submission of motivation letters for courses) by completing the Financial Assistance Application Section (underneath the section for entering abstract/motivation letter information). The link to the portal can be found in the registration confirmation email that you will receive after registering for the conference or course.

For conferences, if you are not submitting an abstract, you can still apply for financial assistance in the submission portal by following the instructions here. Note that priority will be given to those submitting an abstract to present at the conference. In your application you will be asked to answer questions regarding your motivation for applying, and, for registration fee waivers, the reasons why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

*For some events, applications for Childcare Grants will still be done by email. Information about the grant will be sent out shortly after the abstract/motivation letter deadline. Please contact the event Conference Officer if you have any questions.

Selection

The scientific organisers will select the recipients of registration fee waivers during the abstract selection process for conferences and the participant selection process for courses. Results will be announced approximately 3 – 4 weeks before the event start date. Selection results do not impact your admission to the meeting. Registration fee waiver selection is based on your current work or study location, your motivation for applying, the reasons for needing financial support and the impact this event will have on your career. Childcare grants are allocated based on career stage, with priority given to early stage researchers.

Further details

A list of external funding opportunities can be found here, and information on attending a conference as an event reporter here.

For further information about financial assistance please refer to the FAQ page.

Virtual Participation Guidelines

Guidelines

Please do:

  • Use the event-specific hashtag as communicated during the event for any related tweets
  • Tweet unless the speaker specifically says otherwise
  • Be mindful of unpublished data
  • Be respectful in tone and content

Please don’t:

  • Share Slack, live stream or poster session links with others
  • Broadcast the conference to unregistered participants
  • Capture, transmit or redistribute data presented at the meeting unless presenter gives explicit consent
  • Use offensive language in your posts
  • Engage in rudeness or personal attacks

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the events Slack workspace for you to enjoy during the event.

How to ask questions

Questions during and after the talks can be asked in live streaming platform. The chair moderates the questions and shares them with the speaker. If time runs out or you think of a question later, you can use Slack to ask your questions in the dedicated session channels or via direct message.

Time zone

The programme is planned based on Central European Summer Time (CEST), unless otherwise stated. As many virtual participants are attending from around the world, we do our best to accomodate as many timezones as possible when creating the programme. Please take your time zone into consideration when planning your attendance.

Virtual event platforms

We are using a virtual event platform for this conference. More information about the platform will be shared ahead of the conference.

Sponsors

Event Sponsors:

Media Partners

EMBO Journal, an EMBO Press journal

Open Biology, a Royal Society journal

International Union of Biochemistry and Molecular Biology


Sponsorship Opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.

Warning

EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials. One current scam campaign of which we are aware is conducted using the name ‘Judy Eastman’ (judy@gopcontact.a2hosted.com) and entails approaches to sponsors offering sponsorship opportunities on EMBL’s behalf. Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences, symposia and courses is handled by EMBL directly and is sent from an official EMBL account. EMBL does not work with any external providers on sponsorship acquisition.

Please also note that:

  • EMBL never provides attendee lists for purchase. Any offers of such are fraudulent.
  • EMBL will never call or email you to ask for your credit card details or to request a payment.
  • All payments are on invoice.

Suspicious communications purportedly from, for or on behalf of EMBL should be reported to EMBL at the following email address sponsoring@embl.de.

Date: 29 Aug - 1 Sep 2021

Location: Virtual


Deadline(s):

Abstract submission: Closed

Registration: Closed


Organisers:

  • Orsolya Barabas
    University of Geneva, Switzerland
    • Julius F. Brennecke
      Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) , Austria
      • Jose L. Garcia-Perez
        Institute of Genetics and Molecular Medicine (IGMM) , UK
        • John V. Moran
          University of Michigan Medical School , USA

        Contact: Diah Yulianti

        Download event poster


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