{"id":496,"date":"2022-04-05T09:05:52","date_gmt":"2022-04-05T09:05:52","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/annual-report\/?page_id=496"},"modified":"2022-06-07T09:55:49","modified_gmt":"2022-06-07T09:55:49","slug":"more-than-a-gut-feeling","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/annual-report\/ar2021\/more-than-a-gut-feeling","title":{"rendered":"More than a \u2018gut feeling\u2019"},"content":{"rendered":"\n\n  <style>\n    .vf-hero {\n              --vf-hero--bg-image: url('https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/05\/20220524_AR2021_banners-scaled.jpg');\n            }\n\n  <\/style>\n<section id=\"\" class=\"vf-hero | vf-u-fullbleed  | vf-u-margin__bottom--0\">\n  <div class=\"vf-hero__content | vf-box | vf-stack vf-stack--400\">\n        <h1 class=\"vf-hero__heading\">\n              Annual Report 2021          <\/h1>\n\n        <p class=\"vf-hero__subheading\">A year of exceptional life science research, training, service, industry collaboration, and integration of European life science research.<\/p>\n    \n    \n      <\/div>\n<\/section>\n<!--\/vf-hero-->\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h1 class=\"wp-block-heading\">More than a \u2018gut feeling\u2019<\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">From establishing new collaborations to developing innovative new approaches, EMBL researchers made great strides in their exploration of the human gut microbiome in 2021.<\/h2>\n\n\n\n<figure class=\"vf-figure wp-block-image size-full is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"600\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/211013_typas_antibiotics-gut-microbiome_wordpress.jpeg\" alt=\"Illustration of a community of bacteria. Pills represent an antibiotic that can be used to treat an infection, and a second drug that could protect many gut bacteria from antibiotics.\" class=\"wp-image-557\" srcset=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/211013_typas_antibiotics-gut-microbiome_wordpress.jpeg 1000w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/211013_typas_antibiotics-gut-microbiome_wordpress-300x180.jpeg 300w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/211013_typas_antibiotics-gut-microbiome_wordpress-768x461.jpeg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"vf-figure__caption\">EMBL researchers and colleagues have analysed the effects of 144 antibiotics on our most common gut microbes. Their study substantially improves our understanding of antibiotics\u2019 effects. Credit: Isabel Romero Calvo\/EMBL<\/figcaption><\/figure>\n\n\n\n<p>The last decade clearly demonstrated how scientists&nbsp; are only now beginning to appreciate the intricacies of our close relationship with the trillions of microorganisms and viruses that live on and within our body. From immunity to nutrition to behaviour, the microbiome affects us to such an extent that some compare it to a new, unexplored human organ.<\/p>\n\n\n\n<p>In 2021, EMBL researchers united skills across disciplines, often generating new tools and methods to circumvent technical challenges that had previously stalled this field of microbiome research.<\/p>\n\n\n\n<p>Perhaps exemplifying this approach, a study from EMBL Heidelberg\u2019s Bork Group<a href=\"https:\/\/www.embl.org\/news\/science\/gut-microbiome-changes-over-time\/\"> used metagenomics<\/a> \u2013 the study of all of the genes from many different organisms in a population \u2013 to investigate the persistence and evolution of different bacteria in the human gut. By analysing the metagenomes of stool samples from over 2,000 individuals, the researchers could identify patterns in how bacterial communities changed over time and clustered in certain geographical regions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The effect of antibiotics<\/h2>\n\n\n\n<p>Antibiotic impacts on gut flora were driven home by other EMBL studies in 2021,<a href=\"https:\/\/www.embl.org\/news\/science\/antibiotics-effects-microbiome\/\"> including one<\/a> that systematically analysed the effects of 144 antibiotics on 27 of the most common gut microbes. Researchers found that two common families of antibiotics \u2013 tetracyclines and macrolides \u2013 not only stopped bacterial growth, but also killed off whole groups of bacteria, potentially leading to a more persistent, sometimes permanent, loss of these species from the gut microbiome.<\/p>\n\n\n\n<p>However, the researchers didn\u2019t just characterise the harmful effects of antibiotics but also investigated potential solutions. They identified several non-antibiotic drugs that could rescue gut microbes when co-administered with antibiotics, while still effectively killing the targeted pathogens. Such combination therapies may represent a leap forward towards mitigating the consequences of prolonged antibiotic exposure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The effects of prescription drugs&nbsp;<\/h2>\n\n\n\n<p>Antibiotics are not the only drugs that affect the gut microbiome, however. Using multi-omics data from more than 2,000 patients with cardiometabolic diseases, EMBL researchers and their collaborators studied<a href=\"https:\/\/www.embl.org\/news\/science\/the-impact-of-drugs-on-gut-microbes-is-greater-than-we-thought\/\"> the effect of commonly prescribed drugs on the gut microbiome<\/a>. Surprisingly, they found drugs can affect the host microbiome more strongly than disease, diet, and smoking combined. This finding corroborated previous reports, as the gut microbiome of patients taking multiple courses of antibiotics over five years became less healthy and showed signs of antimicrobial resistance.&nbsp;<\/p>\n\n\n\n<p>Interestingly, effective drug dosage can be also influenced by microbes as drug-microbe interactions are reciprocal. Case reports have shown in the past that microbes can metabolise drugs, but now a study from the Patil, Typas, and Bork groups<a href=\"https:\/\/www.embl.org\/news\/science\/medications-gut-bacteria\/\"> demonstrated for the first time<\/a> the bioaccumulation of various drugs by gut microbes, affecting the bioavailability of the drugs. Bioaccumulation refers to microbes\u2019 intracellular storage of drugs, without any type of chemical modification. Studying the effect of 15 different drugs, including antidepressants, antidiabetics, and asthma drugs on 25 selected bacterial species, the researchers discovered 70 different drug-microbe interactions, 41 of which were completely new, suggesting that many more are still to be discovered.<\/p>\n\n\n\n<figure class=\"vf-figure wp-block-image size-full is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"600\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/210999_Patil_Drug-accumulation_wordpress.jpeg\" alt=\"Illustration of two halves of a pill, which releases chemical molecules that are taken up by gut bacteria in the vicinity.\" class=\"wp-image-558\" srcset=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/210999_Patil_Drug-accumulation_wordpress.jpeg 1000w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/210999_Patil_Drug-accumulation_wordpress-300x180.jpeg 300w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/210999_Patil_Drug-accumulation_wordpress-768x461.jpeg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"vf-figure__caption\">Commonly used drugs accumulate in human gut bacteria, which can affect the drugs&#8217; effectiveness and change the bacteria&#8217;s metabolism. Credit: Aleksandra Krolik\/EMBL<\/figcaption><\/figure>\n\n\n\n<p>These results represent only a snapshot of the many advances in microbiome research EMBL achieved in 2021. Demonstrating EMBL\u2019s collaborative spirit, the studies involved more than 20 different research institutes spread across European member states. Their collective insights may influence dietary and medical interventions, individualised treatment and prevention strategies, development of tailored probiotics, and much more. And more is yet to come. EMBL is beginning its <a href=\"https:\/\/www.embl.org\/about\/programme\/\">new Programme, \u2018Molecules to Ecosystems\u2019<\/a> in 2022 with a new transversal research theme \u2018Microbial Ecosystems\u2019, which will take these investigations and others even further.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<div style=\"height:244px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<article class=\"vf-card vf-card--brand vf-card--striped vf-u-margin__bottom--800\" default>\n  \n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n          <h3 class=\"vf-card__heading\">\n                  <a class=\"vf-card__link\" href=\"https:\/\/www.embl.org\/about\/info\/annual-report\/ar2021\/mapping-microbiomes-the-power-of-data\" target=\"\">\n        \n        Mapping microbiomes: the power of microbial communities \n                  <svg aria-hidden=\"true\" class=\"vf-card__heading__icon | vf-icon vf-icon-arrow--inline-end\" width=\"1em\" height=\"1em\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n            <path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"currentColor\" fill-rule=\"nonzero\"><\/path>\n          <\/svg>\n        <\/a>\n              <\/h3>\n    \n    \n          <p class=\"vf-card__text\"><!-- wp:paragraph --><\/p>\n<p class=\"vf-card__text\"><span style=\"font-weight: 400\">Communities of microbes, known as microbiomes, are being increasingly studied by researchers around the world. EMBL researchers are contributing to this effort by characterising and analysing diverse microbial ecosystems, as well as offering automated analysis pipelines and archiving microbiome data.<\/span><\/p>\n<p class=\"vf-card__text\"><!-- \/wp:paragraph --><\/p>\n      <\/div>\n<\/article>\n\n\n\n<div class=\"vf-embed vf-embed--16x9 | vf-u-margin__bottom--400\"\n>\n<iframe src=\"https:\/\/www.youtube.com\/embed\/4NQAmYvBfRc\" frameborder=\"0\" controls allowfullscreen><\/iframe><\/div>\n\n  \n<figcaption class=\"vf-figure__caption vf-u-margin__top--200\"><p>Microbiome research has been and continues to be an important part of EMBL&#8217;s research portfolio.<\/p>\n<\/figcaption>\n\n\n\n\n<hr class=\"vf-divider\">\n\n\n<div class=\"vf-content-hub-html\" data-cache=\"82ec470a\">\n    \n  <!-- Generated by: http:\/\/content.embl.org\/api\/v1\/pattern.html?filter-content-type=person&amp;filter-field-contains%5Bfield_person_full_name%5D=Germana%20Baldi&amp;filter-fields-empty=field_person_visible_internally&amp;filter-ref-entity%5Bfield_person_positions%5D%5Btitle%5D=&amp;filter-ref-entity%5Bfield_person_positions%5D%5Bfield_position_primary%5D=1&amp;hide%5Bname%2Cposition%2Cteam%2Cemail%2Cphones%2Corcid%5D=1&amp;limit=1&amp;pattern=vf-profile-block -->\n\n          \n    <article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--block\" data-embl-js-conditional-edit=\"85024\">\n\n              <img decoding=\"async\" class=\"vf-profile__image\" src=\"http:\/\/content.embl.org\/\/sites\/default\/files\/styles\/medium\/public\/persons\/CP-60035179.jpg?itok=a0Gv2SZ8\" alt=\"image of \" \/>\n      \n      \n      \n      \n      \n            \n                          \n      \n      <a class=\"vf-text vf-text--body-r vf-link embl-conditional-edit\" rel=\"noopener noreferrer nofollow\" href=\"\/node\/85024\" target=\"_blank\">\n        Edit\n      <\/a>\n    <\/article>\n  <\/div>\n\n\n\n<p class=\"has-text-align-left vf-u-text-color--green vf-text--body vf-text-body--2\"><em>\u201cLooking at the parts to understand the whole is increasingly essential in microbiome research. As this has been a constant within EMBL\u2019s approach, it\u2019s exciting to be a part of that energy here and to see what new knowledge unfolds.\u201d<\/em><\/p>\n\n\n\n<p class=\"has-text-align-left  vf-text--body vf-text-body--5\"><em><em>\u2014<\/em><\/em> Germana Baldi, Bioinformatician<a href=\"https:\/\/www.ebi.ac.uk\/about\/teams\/microbiome-informatics\/\">, Microbiome Informatics<\/a>, EMBL-EBI<\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--block | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"200\" height=\"200\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Kiran_-Patil_MicrobiomeCROPPED.jpg\" class=\"vf-profile__image\" alt=\"\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Kiran_-Patil_MicrobiomeCROPPED.jpg 200w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Kiran_-Patil_MicrobiomeCROPPED-150x150.jpg 150w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/>\n    <h3 class=\"vf-profile__title\" style=\"text-align: center;\">\n                                <\/h3>\n    \n    \n    \n      \n\n    \n<\/article>\n\n\n\n<p class=\"has-text-align-left vf-u-text-color--green vf-text--body vf-text-body--2\"><em>\u201cThrough combining a broad range of research areas, EMBL was pivotal to advancing the molecular understanding of drug-microbiome interactions. Few research institutions offer this level of research diversity and support\u201d<\/em><\/p>\n\n\n\n<p class=\"has-text-align-left  vf-text--body vf-text-body--5\">\u2014 Kiran Patil, Director of Research at the MRC Toxicology Unit, University of Cambridge; Group Leader at EMBL, 2010\u2013201<em>9<\/em><\/p>\n\n\n\n<hr class=\"vf-divider\">\n\n\n\n<div class=\"vf-box vf-box--easy vf-box-theme--tertiary | vf-u-margin__bottom--400\">\n      <h3 class=\"vf-box__heading\">\n                Explore more 2021 EMBL microbiome research highlights:                  <\/h3> \n        <p class=\"vf-box__text\"><!-- wp:list --><\/p>\n<ul>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.embl.org\/news\/science\/gut-microbiome-changes-over-time\/\"><span style=\"font-weight: 400\">How our gut microbiome changes over time<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.embl.org\/news\/science\/antibiotics-effects-microbiome\/\"><span style=\"font-weight: 400\">Tackling the collateral damage from antibiotics<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.embl.org\/news\/science\/the-impact-of-drugs-on-gut-microbes-is-greater-than-we-thought\/\"><span style=\"font-weight: 400\">The impact of drugs on gut microbes is greater than we thought<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.embl.org\/news\/science\/medications-gut-bacteria\/\"><span style=\"font-weight: 400\">Common medications accumulate in gut bacteria<\/span><\/a><\/li>\n<\/ul>\n<p class=\"vf-box__text\"><!-- \/wp:list --><\/p>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">References<\/h3>\n\n\n\n<p class=\"vf-text--body vf-text-body--5\"><a href=\"https:\/\/www.embl.org\/news\/science\/gut-microbiome-changes-over-time\/\">Kl\u00fcnemann M, Andrejev S, Blasche S, Mateus A <em>et al. <\/em>(2021). <\/a><a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03891-8\">Bioaccumulation of therapeutic drugs by human gut bacteria<\/a>. <em>Nature<\/em>, 8 September 2021. DOI: 10.1038\/s41586-021-03891<\/p>\n\n\n\n<p class=\"vf-text--body vf-text-body--5\">Forslund SK, Chakaroun R, Zimmermann-Kogadeeva M, Mark\u00f3 L, Aron-Wisnewsky J, Nielsen T <em>et al.<\/em> (2021). <a href=\"https:\/\/www.nature.com\/articles\/s41586-021-04177-9\">Combinatorial, additive and dose-dependent drug microbiome associations<\/a>. <em>Nature<\/em>, 16 December 2021. DOI: 10.1038\/s41586-021-04177-9<\/p>\n\n\n\n<p class=\"vf-text--body vf-text-body--5\">Maier L, Goemans CV <em>et al.<\/em> (2021). <a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03986-2\">Unravelling the collateral damage of antibiotics on gut bacteria<\/a>. <em>Nature<\/em>, 13 October 2021. DOI: 10.1038\/s41586-021-03986-2<\/p>\n\n\n\n<p class=\"vf-text--body vf-text-body--5\">Hildebrand F <em>et al.<\/em> (2021). <a href=\"https:\/\/www.cell.com\/cell-host-microbe\/fulltext\/S1931-3128(21)00236-5\">Dispersal strategies shape persistence and evolution of human gut bacteria<\/a>. <em>Cell Host &amp; Microbe<\/em>, 9 June 2021. DOI: 10.1016\/j.chom.2021.05.008<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n<style>\n    <\/style>\n\n<section id=\"wp-block-1\">\n  <div class=\"vf-card-container  | vf-u-fullbleed  \n  | vf-u-background-color-ui--grey--light \">\n          <div class=\"vf-section-header | vf-u-margin__bottom--600\">\n        <h2 class=\"vf-section-header__heading\" >\n            <\/h2>\n              <\/div>\n      \n\n<div class=\"embl-grid\"><div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.embl.org\/about\/info\/annual-report\/\">Back to Annual report<\/a><\/h3>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n  <img decoding=\"async\" width=\"1000\" height=\"600\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/skin-microbiome-1000x600-FINAL.jpeg\" class=\"vf-card__image\" alt=\"A circular graph with many lines representing microbial species and a heat map in the background to depict sequencing information\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/skin-microbiome-1000x600-FINAL.jpeg 1000w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/skin-microbiome-1000x600-FINAL-300x180.jpeg 300w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/03\/skin-microbiome-1000x600-FINAL-768x461.jpeg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n          <h3 class=\"vf-card__heading\">\n                  <a class=\"vf-card__link\" href=\"https:\/\/www.embl.org\/about\/info\/annual-report\/ar2021\/mapping-microbiomes-the-power-of-data\" target=\"\">\n        \n        Next article\n                  <svg aria-hidden=\"true\" class=\"vf-card__heading__icon | vf-icon vf-icon-arrow--inline-end\" width=\"1em\" height=\"1em\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n            <path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"currentColor\" fill-rule=\"nonzero\"><\/path>\n          <\/svg>\n        <\/a>\n              <\/h3>\n    \n          <p class=\"vf-card__subheading\">Mapping microbiomes: the power of microbial communities<\/p>\n    \n          <p class=\"vf-card__text\"><span style=\"font-weight: 400\">EMBL research aids understanding of microbial communities and their interconnection with human and planetary health.<\/span><\/p>\n      <\/div>\n<\/article>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n      <img decoding=\"async\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/06\/AR2021_PDF_mock-up_AdobeStock_182004081.jpg\" class=\"vf-card__image\" alt=\"\" loading=\"lazy\" itemprop=\"image\">\n  \n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n          <h3 class=\"vf-card__heading\">\n                  <a class=\"vf-card__link\" href=\"https:\/\/www.embl.org\/documents\/document\/annual-report-2021\/\" target=\"_blank\">\n        \n        Download the annual report summary \n                  <svg aria-hidden=\"true\" class=\"vf-card__heading__icon | vf-icon vf-icon-arrow--inline-end\" width=\"1em\" height=\"1em\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n            <path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"currentColor\" fill-rule=\"nonzero\"><\/path>\n          <\/svg>\n        <\/a>\n              <\/h3>\n    \n    \n          <p class=\"vf-card__text\">A snapshot of EMBL 2021 facts and figures<\/p>\n      <\/div>\n<\/article>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n        <\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":0,"parent":38,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"vf_template_subpage.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-496","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/496","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/comments?post=496"}],"version-history":[{"count":88,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/496\/revisions"}],"predecessor-version":[{"id":3659,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/496\/revisions\/3659"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/38"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/media?parent=496"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/embl_taxonomy?post=496"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}