{"id":1016,"date":"2022-04-08T14:44:24","date_gmt":"2022-04-08T14:44:24","guid":{"rendered":"https:\/\/www.embl.org\/about\/info\/annual-report\/?page_id=1016"},"modified":"2022-06-07T09:49:17","modified_gmt":"2022-06-07T09:49:17","slug":"more-embl-services-highlights","status":"publish","type":"page","link":"https:\/\/www.embl.org\/about\/info\/annual-report\/ar2021\/more-embl-services-highlights","title":{"rendered":"More EMBL Service Highlights"},"content":{"rendered":"\n\n  <style>\n    .vf-hero {\n              --vf-hero--bg-image: url('https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/05\/20220524_AR2021_banners-scaled.jpg');\n            }\n\n  <\/style>\n<section id=\"\" class=\"vf-hero | vf-u-fullbleed  | vf-u-margin__bottom--0\">\n  <div class=\"vf-hero__content | vf-box | vf-stack vf-stack--400\">\n        <h1 class=\"vf-hero__heading\">\n              Annual Report 2021          <\/h1>\n\n        <p class=\"vf-hero__subheading\">A year of exceptional life science research, training, service, industry collaboration, and integration of European life science research.<\/p>\n    \n    \n      <\/div>\n<\/section>\n<!--\/vf-hero-->\n\n\n\n<div class=\"vf-grid | vf-grid__col-3\"><div class=\"vf-grid__col--span-2\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h1 class=\"wp-block-heading\"><strong><strong>More EMBL Service Highlights<\/strong><\/strong><\/h1>\n\n\n\n<h2 class=\"wp-block-heading\">Whether it was chemical biology, multi-omics, gene editing, X-ray beamlines, or myriad microscopy services, EMBL\u2019s core facilities and services supported the advancement of molecular biology during an active 2021.<\/h2>\n\n\n\n<figure class=\"vf-figure wp-block-image size-full is-style-default\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"560\" class=\"vf-figure__image\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Octopus_30d_featured_social-media-m.jpg\" alt=\"Pink and blue dominate a blurry image against a black background that is actually a global image of a 30-day-old Octopus vulgaris\" class=\"wp-image-622\" srcset=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Octopus_30d_featured_social-media-m.jpg 1000w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Octopus_30d_featured_social-media-m-300x168.jpg 300w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Octopus_30d_featured_social-media-m-768x430.jpg 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"vf-figure__caption\">An image of a 30-day-old <em>Octopus vulgaris<\/em>. The Mesoscopic Imaging Facility (MIF) at EMBL Barcelona examined various specimens of embryos, hatchlings, and juveniles of <em>Octopus vulgaris<\/em>, or common octopus, in the frame of a project led by Roger Villanueva from the Institute of Marine Science, ICM-CSIC. These images, obtained by OPTiSPIM1, one of the custom light-sheet microscopes available at EMBL Barcelona\u2019s MIF, show different details of the bodies of octopuses: tree-shaped gills and ephemeral K\u00f6lliker\u2019s organs. Credit: EMBL<\/figcaption><\/figure>\n\n\n\n<p>Molecular biology at the frontier hinges on having the tools and talent to probe samples in unprecedented ways. It also means having the foresight to rethink whether and how those tools could be improved. This approach raises the level of research at EMBL and the broader scientific community too.<\/p>\n\n\n\n<p>Here are a few more examples of EMBL scientific services taking the lead in 2021.<\/p>\n\n\n\n<p>EMBL Hamburg researchers investigated the <a href=\"https:\/\/www.embl.org\/news\/science\/glyt1-structure-psychiatric-disorders\/\">&nbsp;neurotransmitter transporter GlyT1<\/a> \u2014 findings that can provide new insights into treating genetic or psychiatric disorders. \u201cFor challenging projects like this, we are happy to put the methodological expertise of our staff to work and to make full use of the technological capabilities of our beamlines and sample preparation facilities,\u201d said Thomas Schneider, Joint Head of Research Infrastructures at EMBL Hamburg, about the GlyT1 study. \u201cThe high-intensity microfocused beam produced by the PETRA III synchrotron on the<a href=\"https:\/\/www.desy.de\/\"> DESY campus<\/a> and the versatile high-precision<a href=\"https:\/\/www.arinax.com\/x-ray-diffraction\/\"> diffractometer<\/a> that was developed in a collaboration between EMBL Hamburg, EMBL Grenoble, and<a href=\"https:\/\/www.arinax.com\/\"> ARINAX<\/a> were key for this project.\u201d<\/p>\n\n\n\n<p><strong>EMBL Grenoble scientists further improved the <\/strong><a href=\"https:\/\/www.embl.org\/services-facilities\/grenoble\/high-throughput-crystallisation\/\"><strong>CrystalDirect<\/strong><\/a><strong> technology<\/strong> that had been created there only five years previously. The new additions allow scientists to automate sample preparation. Researchers can now apply this technology to membrane proteins, which offers a new opportunity for high-throughput drug discovery. The MASSIF-1 beamline run by experts at EMBL Grenoble in collaboration with colleagues at the European Synchrotron Radiation Facility (ESRF) will receive a robotic addition to realise this new potential in 2022.&nbsp;<\/p>\n\n\n\n<p>The <a href=\"https:\/\/www.embl.org\/news\/science\/salmonella-proteins\/\"><strong>Proteomics<\/strong><\/a><strong> Core Facility enabled EMBL scientists to better understand how <\/strong><strong><em>Salmonella <\/em><\/strong><strong>hijacks host cell machinery <\/strong>to promote its own growth and reproduction. At EMBL Heidelberg, scientists uncovered new details of this unusual survival strategy. Analysing protein interactions in <em>Salmonella<\/em>-infected cells, they identified which host cell pathways and bacterial \u2018effector\u2019 proteins the bacterium uses to commandeer cell nutrients that allow it<em> <\/em>to thrive.<\/p>\n\n\n\n<p><strong>EMBL\u2019s<\/strong><a href=\"https:\/\/www.embl.org\/news\/lab-matters\/analysis-and-sorting-with-flow-cytometry\/\"><strong> <\/strong><strong>flow cytometry facilities<\/strong><\/a><strong> in both Rome and Heidelberg<\/strong> continued to adapt to an increasingly multidisciplinary environment, one that will begin exploring living systems in their natural context. That means expanding training and collaboration and being prepared for increasing numbers of researchers with work that goes beyond simply analysing and sorting human cells.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.embl.org\/news\/science\/the-secret-life-of-baby-octopuses\/\"><strong>At EMBL Barcelona, the Mesoscopic Imaging Facility (MIF)<\/strong><\/a><strong> <\/strong>helped in studying a unique feature in octopi: K\u00f6lliker\u2019s organs. These structures, whose function is unknown, are present in embryos but disappear before adulthood. With partners from the Institut de Ci\u00e8ncies del Mar at CSIC in Spain, MIF\u2019s light-sheet microscopy helped obtain a clear picture of K\u00f6lliker organ distribution on the skin\u2019s surface, allowing a view of the entire sample and preserving specimens for future observation.<\/p>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<div style=\"height:281px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"vf-embed vf-embed--16x9\">\n<iframe loading=\"lazy\" title=\"EMBL Barcelona\u2019s Mesoscopic Imaging Facility supports infectious disease research\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/U1gfpJ-qesc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"height:13px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-embed-handler wp-block-embed-embed-handler wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"vf-embed vf-embed--16x9\">\n<iframe loading=\"lazy\" title=\"EMBL Hamburg\u2019s services and facilities for structural biology support neuroscience research\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/vg5qLQfvdf8?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<div style=\"height:29px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<article class=\"vf-profile vf-profile--very-easy vf-profile--medium vf-profile--block | vf-u-margin__bottom--400\">\n\n    <img decoding=\"async\" width=\"155\" height=\"175\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/05\/nuJ9_VFf_400x400.jpg\" class=\"vf-profile__image\" alt=\"\" loading=\"lazy\" itemprop=\"image\" \/>\n    <h3 class=\"vf-profile__title\" style=\"text-align: center;\">\n                                <\/h3>\n    \n    \n    \n      \n\n    \n<\/article>\n\n\n\n<p class=\"has-text-align-left vf-u-text-color--green vf-text--body vf-text-body--2\"><em>\u201cThe crystals were very small and difficult to image. We chose to measure them at EMBL Hamburg\u2019s beamline P14, which is well suited for challenging experiments like this one.\u201d<\/em><\/p>\n\n\n\n<p class=\"has-text-align-left  vf-text--body vf-text-body--5\">\u2014 Azadeh Shahsavar, Assistant Professor at Aarhus University; Postdoc at EMBL Hamburg, 2016\u20132019<\/p>\n\n\n\n<div class=\"vf-box vf-box--easy vf-box-theme--tertiary | vf-u-margin__bottom--400\">\n      <h3 class=\"vf-box__heading\">\n                Explore more 2021 EMBL experimental services highlights:                  <\/h3> \n        <ul>\n<li><a href=\"https:\/\/www.embl.org\/news\/science\/glyt1-structure-psychiatric-disorders\/\"><span style=\"font-weight: 400\">New perspectives for treating psychiatric disorders | EMBL<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.embl.org\/news\/science\/salmonella-proteins\/\"><span style=\"font-weight: 400\">New insights into Salmonella\u2019s survival strategies<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.embl.org\/news\/lab-matters\/analysis-and-sorting-with-flow-cytometry\/\"><span style=\"font-weight: 400\">Analysis and sorting with flow cytometry<\/span><\/a><\/li>\n<li style=\"font-weight: 400\"><a href=\"https:\/\/www.embl.org\/news\/science\/the-secret-life-of-baby-octopuses\/\"><span style=\"font-weight: 400\">The secret life of baby octopuses<\/span><\/a><\/li>\n<\/ul>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading\">References<\/h3>\n\n\n\n<p class=\"vf-text--body vf-text-body--5\">Shahsavar A <em>et al. <\/em>(2021). <a href=\"https:\/\/www.nature.com\/articles\/s41586-021-03274-z\">Structural insights into the inhibition of glycine reuptake<\/a><em>. Nature<\/em>, 3 March 2021. DOI: 10.1038\/s41586-021-03274-z<\/p>\n\n\n\n<p class=\"vf-text--body vf-text-body--5\">Walch P, Selkrig J, <em>et al. <\/em>(2021). <a href=\"https:\/\/www.cell.com\/cell-host-microbe\/fulltext\/S1931-3128(21)00282-1\">Global mapping of Salmonella enterica\u2013host protein\u2013protein interactions during infection<\/a>. <em>Cell Host &amp; Microbe<\/em>, 7 July 2021. DOI: 10.1016\/j.chom.2021.06.004<\/p>\n\n\n\n<p class=\"vf-text--body vf-text-body--5\">Villanueva R, <em>et al. <\/em>(2021). <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmars.2021.645738\/full\">Born With Bristles: New Insights on the K\u00f6lliker\u2019s Organs of Octopus Skin<\/a>. <em>Frontiers in Marine Science<\/em>, 10 May 2021. DOI: 10.3389\/fmars.2021.645738<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n<style>\n    <\/style>\n\n<section id=\"wp-block-1\">\n  <div class=\"vf-card-container  | vf-u-fullbleed  \n  | vf-u-background-color-ui--grey--light \">\n          <div class=\"vf-section-header | vf-u-margin__bottom--600\">\n        <h2 class=\"vf-section-header__heading\" >\n            <\/h2>\n              <\/div>\n      \n\n<div class=\"embl-grid\"><div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<h3 class=\"wp-block-heading\"><a href=\"https:\/\/www.embl.org\/about\/info\/annual-report\/\">Back to Annual report<\/a><\/h3>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n  <img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Arise-ShengLiu-1024x683.jpg\" class=\"vf-card__image\" alt=\"Female scientist stands in dark room with instrumentation\" loading=\"lazy\" itemprop=\"image\" srcset=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Arise-ShengLiu-1024x683.jpg 1024w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Arise-ShengLiu-300x200.jpg 300w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Arise-ShengLiu-768x512.jpg 768w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Arise-ShengLiu-1536x1025.jpg 1536w, https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/04\/Arise-ShengLiu-2048x1366.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/>\n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n          <h3 class=\"vf-card__heading\">\n                  <a class=\"vf-card__link\" href=\"https:\/\/www.embl.org\/about\/info\/annual-report\/ar2021\/embl-welcomes-first-generation-of-arise-fellows\" target=\"\">\n        \n        Next Story\n                  <svg aria-hidden=\"true\" class=\"vf-card__heading__icon | vf-icon vf-icon-arrow--inline-end\" width=\"1em\" height=\"1em\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n            <path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"currentColor\" fill-rule=\"nonzero\"><\/path>\n          <\/svg>\n        <\/a>\n              <\/h3>\n    \n          <p class=\"vf-card__subheading\">EMBL welcomes first generation of ARISE fellows<\/p>\n    \n          <p class=\"vf-card__text\"><span style=\"font-weight: 400\">Participating researchers will lead projects to develop novel technologies for better science.<\/span><\/p>\n      <\/div>\n<\/article>\n\n<\/div>\n<\/div>\n\n\n<div class=\"\"><!--[vf\/content]-->\n<div class=\"vf-content\">\n\n<article class=\"vf-card vf-card--brand vf-card--bordered vf-u-margin__bottom--800\" default>\n      <img decoding=\"async\" src=\"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-content\/uploads\/2022\/06\/AR2021_PDF_mock-up_AdobeStock_182004081.jpg\" class=\"vf-card__image\" alt=\"\" loading=\"lazy\" itemprop=\"image\">\n  \n  <div class=\"vf-card__content | vf-stack vf-stack--400\">\n          <h3 class=\"vf-card__heading\">\n                  <a class=\"vf-card__link\" href=\"https:\/\/www.embl.org\/documents\/document\/annual-report-2021\/\" target=\"_blank\">\n        \n        Download the annual report summary \n                  <svg aria-hidden=\"true\" class=\"vf-card__heading__icon | vf-icon vf-icon-arrow--inline-end\" width=\"1em\" height=\"1em\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n            <path d=\"M0 12c0 6.627 5.373 12 12 12s12-5.373 12-12S18.627 0 12 0C5.376.008.008 5.376 0 12zm13.707-5.209l4.5 4.5a1 1 0 010 1.414l-4.5 4.5a1 1 0 01-1.414-1.414l2.366-2.367a.25.25 0 00-.177-.424H6a1 1 0 010-2h8.482a.25.25 0 00.177-.427l-2.366-2.368a1 1 0 011.414-1.414z\" fill=\"currentColor\" fill-rule=\"nonzero\"><\/path>\n          <\/svg>\n        <\/a>\n              <\/h3>\n    \n    \n          <p class=\"vf-card__text\">A snapshot of EMBL 2021 facts and figures<\/p>\n      <\/div>\n<\/article>\n\n<\/div>\n<\/div>\n<\/div>\n\n\n        <\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":0,"parent":38,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"vf_template_subpage.php","meta":{"_acf_changed":false,"footnotes":""},"embl_taxonomy":[],"class_list":["post-1016","page","type-page","status-publish","hentry"],"acf":[],"embl_taxonomy_terms":[],"_links":{"self":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/1016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/comments?post=1016"}],"version-history":[{"count":46,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/1016\/revisions"}],"predecessor-version":[{"id":3652,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/1016\/revisions\/3652"}],"up":[{"embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/pages\/38"}],"wp:attachment":[{"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/media?parent=1016"}],"wp:term":[{"taxonomy":"embl_taxonomy","embeddable":true,"href":"https:\/\/www.embl.org\/about\/info\/annual-report\/wp-json\/wp\/v2\/embl_taxonomy?post=1016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}