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EMBL
Monterotondo |
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| www.embl-monterotondo.it |
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The EMBL Monterotondo campus is situated in a green park on the banks of the Tiber river, 20 km north of central Rome. The Eternal City is an easy train ride away, and the nearby Lazio countryside features medieval hill towns, spectacular mountain terrain and lakes for hiking, biking, skiing and swimming. EMBL shares the Monterotondo campus with Italian national research groups [IBC-CNR] and the headquarters of the European Mouse Mutant Archive [EMMA].
The
EMBL Mouse Biology Unit is centred in Monterotondo
but includes groups at other EMBL sites. The Unit
was established to capture new opportunities in
mouse functional genomics, and to exploit applications
of mouse genetic manipulation to biomedical problems.
Alliances with other European academic research
and clinical centres have established EMBL Monterotondo
as a hub for the international mouse research community.
Participation of the Outstation in several EU-wide
mouse research and information initiatives serves
to link genetics/genomics, phenotyping, physiology
and translational features.
Recent expansion of
the Outstation has retained the original emphasis
on developmental mechanisms and extended capabilities
to cover adult mammalian physiology and disease.
Naturally converging interests between the groups
include new collaborative explorations in developmental
neurobiology, genetic and pharmacologic manipulations
of adult behaviour, inflammation and regenerative
processes, stem cell biology and biomedical applications.
A new, state-of-the-art animal facility provides
a full range of mouse transgenic and gene knockout
production, rederivation and cryopreservation services,
and a fully-equipped behaviour phenotyping suite.
The continued refinement of gene regulation in
vivo is focused on generating more accurate
models of human pathologies and multigenic disorders
through the development of conditional and inducible
mouse mutations. Other centralised core facilities
provide a wide array of technologies to the scientific
community. Interaction with clinical groups through
the newly formed EMBL
Centre for Disease Mechanisms provides exciting
opportunities for application of basic research
to advanced disease diagnosis and treatment.
Development of an EMBL Monterotondo course curriculum,
focusing on mouse genetic manipulation in collaboration
with local faculty at CNR, EMMA and The Jackson
Laboratory, reflects EMBL's longstanding tradition
of transmitting new information and expertise. A
dynamic seminar series and a visiting researcher
programme, together with active collaborations with
research groups throughout the world, integrates
the science at EMBL Monterotondo with the international
mouse biological community. |
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