ELMI
- European Light Microscopy Initiative
ELMI
- European Light Microscopy Initiative
|
Institute of Molecular Biology, Biochemistry
and Microbiology IMBM-Biochemistry University of Graz |
| Contact: Sepp
D. Kohlwein E-mail: sepp.kohlwein@uni-graz.at |
| Our research interests focus on fatty acid and neutral lipid (triglyceride) metabolism in the yeast Saccharomyces cerevisiae, which we use as a model system to study and eventually understand lipid-associated disorders in humans. Our experimental approach involves biochemical, molecular, and cell biological techniques as well as genomics, and bioinformatics. For microscopists, yeast provides a substantial challenge due to its small size of 5-8 micro meters (Mirosc Res Tech. 2000, 51(6):511-29). Studies in our laboratory on protein localization and organelle structure and dynamics are based on the expression of GFP fusions and detection by video and confocal laser scanning microscopy (Leica TCS 4d Confocal microscope and a Hamamatsu Argus 10 video system). We have recently established a web-accessible yeast protein localization database, YPL.db (http://ypl.uni-graz.at; Nucleic Acids Res. 2002, 30: 80-83), that displays microscopic localization patterns of proteins involved in lipid metabolism. |
Last modified 18 August 2003 by Maria Smedh